Seasonal variation of eosinophil counts in histologically normal colonic mucosal biopsies
The eosinophil counts in colonic biopsies are affected by geographical and possibly seasonal variations. This study aims to investigate the significance of seasonal variations of eosinophil counts in histologically normal colonic mucosal biopsies. This is a retrospective, cross sectional study that...
Gespeichert in:
| Veröffentlicht in: | Malaysian journal of pathology 2023-04, Vol.45 (1), p.11-18 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 18 |
|---|---|
| container_issue | 1 |
| container_start_page | 11 |
| container_title | Malaysian journal of pathology |
| container_volume | 45 |
| creator | Elshebli, S Obeid, J Abudalu, L Albayati, A Abo Osba, M Alsadeq, O Awad, H |
| description | The eosinophil counts in colonic biopsies are affected by geographical and possibly seasonal variations. This study aims to investigate the significance of seasonal variations of eosinophil counts in histologically normal colonic mucosal biopsies.
This is a retrospective, cross sectional study that included 337 cases of normal colonic biopsies. The number of eosinophils per high power field was counted in the most densely populated area. The eosinophilic counts were compared among genders, age groups, biopsy sites and in various months and seasons. Two tailed T-test was used to compare means and a p value < 0.05 was considered significant.
173 (51%) of cases were from males. The age range was between 18-82 with the mean being 51.7 years (SD= 17.5). 181 (54%) biopsies were from the right colon and 156 (46%) from the left colon. There was a statistically significant difference between eosinophil counts in the right colon (mean 20.2, SD 13.2) and left colon (mean 13.8, SD10.1); p value |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2807908543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2807908543</sourcerecordid><originalsourceid>FETCH-LOGICAL-p239t-17d5014080da6f73707a3d2f9f7f84fe6aa7bc988a4e009c08069dad63849deb3</originalsourceid><addsrcrecordid>eNpd0E1LxDAQBuAcFHdd_QsS8OKlkCZtPo6y-LGw4EE9eCrTNnGzpJnatML-e7u4XjwNw_sw8M4ZWbKcy0xLUS7IZUp7xmRhjL4gC6Hy3PCCL8nHq4WEEQL9hsHD6DFSdNRi8hH7nQ-0wSmOifpIdz6NGPDTNxDCgUYcOjjmAaNvaDc1mOa99tgnb9MVOXcQkr0-zRV5f3x4Wz9n25enzfp-m_VcmDHLVVuyvGCatSCdEoopEC13ximnC2clgKobozUUljHTzFCaFlopdGFaW4sVufu92w_4Ndk0Vp1PjQ0BosUpVVwzZZguCzHT2390j9Mwlz8qbrQqSyZndXNSU93ZtuoH38FwqP6eJn4A8btoRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2829875506</pqid></control><display><type>article</type><title>Seasonal variation of eosinophil counts in histologically normal colonic mucosal biopsies</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Elshebli, S ; Obeid, J ; Abudalu, L ; Albayati, A ; Abo Osba, M ; Alsadeq, O ; Awad, H</creator><creatorcontrib>Elshebli, S ; Obeid, J ; Abudalu, L ; Albayati, A ; Abo Osba, M ; Alsadeq, O ; Awad, H</creatorcontrib><description>The eosinophil counts in colonic biopsies are affected by geographical and possibly seasonal variations. This study aims to investigate the significance of seasonal variations of eosinophil counts in histologically normal colonic mucosal biopsies.
This is a retrospective, cross sectional study that included 337 cases of normal colonic biopsies. The number of eosinophils per high power field was counted in the most densely populated area. The eosinophilic counts were compared among genders, age groups, biopsy sites and in various months and seasons. Two tailed T-test was used to compare means and a p value < 0.05 was considered significant.
173 (51%) of cases were from males. The age range was between 18-82 with the mean being 51.7 years (SD= 17.5). 181 (54%) biopsies were from the right colon and 156 (46%) from the left colon. There was a statistically significant difference between eosinophil counts in the right colon (mean 20.2, SD 13.2) and left colon (mean 13.8, SD10.1); p value <0.001. The mean eosinophil counts was highest in autumn (21.1) followed by spring (18.3). The counts in winter and summer were close (15.2 and 15.1 respectively). There was a statistically significant difference between counts in autumn and summer (p=0.013) and between autumn and winter (p=0.008). However, there was no statistically significant differences between autumn and spring counts (p=0.183). When stratified according to site, this pattern of statistical significance was observed in the right colon but not the left colonic mucosal biopsies.
There are significant seasonal variations of eosinophil counts in normal colonic biopsies which are more pronounced in the right colon. Pathologists and gastroenterologists need to be aware of these variations and to take them into account when determining if a patient has tissue eosinophilia.</description><identifier>ISSN: 0126-8635</identifier><identifier>PMID: 37119242</identifier><language>eng</language><publisher>Malaysia: College of Pathologists, Academy of Medicine of Malaysia</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Bone marrow ; Colon ; Cross-Sectional Studies ; Eosinophils - pathology ; Female ; Gastroenterology ; Histopathology ; Humans ; Inflammatory bowel disease ; Male ; Middle Aged ; Proteins ; Rectum ; Retrospective Studies ; Seasonal variations ; Seasons ; Young Adult</subject><ispartof>Malaysian journal of pathology, 2023-04, Vol.45 (1), p.11-18</ispartof><rights>Copyright College of Pathologists, Academy of Medicine of Malaysia Apr 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37119242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elshebli, S</creatorcontrib><creatorcontrib>Obeid, J</creatorcontrib><creatorcontrib>Abudalu, L</creatorcontrib><creatorcontrib>Albayati, A</creatorcontrib><creatorcontrib>Abo Osba, M</creatorcontrib><creatorcontrib>Alsadeq, O</creatorcontrib><creatorcontrib>Awad, H</creatorcontrib><title>Seasonal variation of eosinophil counts in histologically normal colonic mucosal biopsies</title><title>Malaysian journal of pathology</title><addtitle>Malays J Pathol</addtitle><description>The eosinophil counts in colonic biopsies are affected by geographical and possibly seasonal variations. This study aims to investigate the significance of seasonal variations of eosinophil counts in histologically normal colonic mucosal biopsies.
This is a retrospective, cross sectional study that included 337 cases of normal colonic biopsies. The number of eosinophils per high power field was counted in the most densely populated area. The eosinophilic counts were compared among genders, age groups, biopsy sites and in various months and seasons. Two tailed T-test was used to compare means and a p value < 0.05 was considered significant.
173 (51%) of cases were from males. The age range was between 18-82 with the mean being 51.7 years (SD= 17.5). 181 (54%) biopsies were from the right colon and 156 (46%) from the left colon. There was a statistically significant difference between eosinophil counts in the right colon (mean 20.2, SD 13.2) and left colon (mean 13.8, SD10.1); p value <0.001. The mean eosinophil counts was highest in autumn (21.1) followed by spring (18.3). The counts in winter and summer were close (15.2 and 15.1 respectively). There was a statistically significant difference between counts in autumn and summer (p=0.013) and between autumn and winter (p=0.008). However, there was no statistically significant differences between autumn and spring counts (p=0.183). When stratified according to site, this pattern of statistical significance was observed in the right colon but not the left colonic mucosal biopsies.
There are significant seasonal variations of eosinophil counts in normal colonic biopsies which are more pronounced in the right colon. Pathologists and gastroenterologists need to be aware of these variations and to take them into account when determining if a patient has tissue eosinophilia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Bone marrow</subject><subject>Colon</subject><subject>Cross-Sectional Studies</subject><subject>Eosinophils - pathology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proteins</subject><subject>Rectum</subject><subject>Retrospective Studies</subject><subject>Seasonal variations</subject><subject>Seasons</subject><subject>Young Adult</subject><issn>0126-8635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0E1LxDAQBuAcFHdd_QsS8OKlkCZtPo6y-LGw4EE9eCrTNnGzpJnatML-e7u4XjwNw_sw8M4ZWbKcy0xLUS7IZUp7xmRhjL4gC6Hy3PCCL8nHq4WEEQL9hsHD6DFSdNRi8hH7nQ-0wSmOifpIdz6NGPDTNxDCgUYcOjjmAaNvaDc1mOa99tgnb9MVOXcQkr0-zRV5f3x4Wz9n25enzfp-m_VcmDHLVVuyvGCatSCdEoopEC13ximnC2clgKobozUUljHTzFCaFlopdGFaW4sVufu92w_4Ndk0Vp1PjQ0BosUpVVwzZZguCzHT2390j9Mwlz8qbrQqSyZndXNSU93ZtuoH38FwqP6eJn4A8btoRg</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Elshebli, S</creator><creator>Obeid, J</creator><creator>Abudalu, L</creator><creator>Albayati, A</creator><creator>Abo Osba, M</creator><creator>Alsadeq, O</creator><creator>Awad, H</creator><general>College of Pathologists, Academy of Medicine of Malaysia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202304</creationdate><title>Seasonal variation of eosinophil counts in histologically normal colonic mucosal biopsies</title><author>Elshebli, S ; Obeid, J ; Abudalu, L ; Albayati, A ; Abo Osba, M ; Alsadeq, O ; Awad, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-17d5014080da6f73707a3d2f9f7f84fe6aa7bc988a4e009c08069dad63849deb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Bone marrow</topic><topic>Colon</topic><topic>Cross-Sectional Studies</topic><topic>Eosinophils - pathology</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proteins</topic><topic>Rectum</topic><topic>Retrospective Studies</topic><topic>Seasonal variations</topic><topic>Seasons</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elshebli, S</creatorcontrib><creatorcontrib>Obeid, J</creatorcontrib><creatorcontrib>Abudalu, L</creatorcontrib><creatorcontrib>Albayati, A</creatorcontrib><creatorcontrib>Abo Osba, M</creatorcontrib><creatorcontrib>Alsadeq, O</creatorcontrib><creatorcontrib>Awad, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Malaysian journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elshebli, S</au><au>Obeid, J</au><au>Abudalu, L</au><au>Albayati, A</au><au>Abo Osba, M</au><au>Alsadeq, O</au><au>Awad, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seasonal variation of eosinophil counts in histologically normal colonic mucosal biopsies</atitle><jtitle>Malaysian journal of pathology</jtitle><addtitle>Malays J Pathol</addtitle><date>2023-04</date><risdate>2023</risdate><volume>45</volume><issue>1</issue><spage>11</spage><epage>18</epage><pages>11-18</pages><issn>0126-8635</issn><abstract>The eosinophil counts in colonic biopsies are affected by geographical and possibly seasonal variations. This study aims to investigate the significance of seasonal variations of eosinophil counts in histologically normal colonic mucosal biopsies.
This is a retrospective, cross sectional study that included 337 cases of normal colonic biopsies. The number of eosinophils per high power field was counted in the most densely populated area. The eosinophilic counts were compared among genders, age groups, biopsy sites and in various months and seasons. Two tailed T-test was used to compare means and a p value < 0.05 was considered significant.
173 (51%) of cases were from males. The age range was between 18-82 with the mean being 51.7 years (SD= 17.5). 181 (54%) biopsies were from the right colon and 156 (46%) from the left colon. There was a statistically significant difference between eosinophil counts in the right colon (mean 20.2, SD 13.2) and left colon (mean 13.8, SD10.1); p value <0.001. The mean eosinophil counts was highest in autumn (21.1) followed by spring (18.3). The counts in winter and summer were close (15.2 and 15.1 respectively). There was a statistically significant difference between counts in autumn and summer (p=0.013) and between autumn and winter (p=0.008). However, there was no statistically significant differences between autumn and spring counts (p=0.183). When stratified according to site, this pattern of statistical significance was observed in the right colon but not the left colonic mucosal biopsies.
There are significant seasonal variations of eosinophil counts in normal colonic biopsies which are more pronounced in the right colon. Pathologists and gastroenterologists need to be aware of these variations and to take them into account when determining if a patient has tissue eosinophilia.</abstract><cop>Malaysia</cop><pub>College of Pathologists, Academy of Medicine of Malaysia</pub><pmid>37119242</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0126-8635 |
| ispartof | Malaysian journal of pathology, 2023-04, Vol.45 (1), p.11-18 |
| issn | 0126-8635 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2807908543 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Biopsy Bone marrow Colon Cross-Sectional Studies Eosinophils - pathology Female Gastroenterology Histopathology Humans Inflammatory bowel disease Male Middle Aged Proteins Rectum Retrospective Studies Seasonal variations Seasons Young Adult |
| title | Seasonal variation of eosinophil counts in histologically normal colonic mucosal biopsies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T10%3A12%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Seasonal%20variation%20of%20eosinophil%20counts%20in%20histologically%20normal%20colonic%20mucosal%20biopsies&rft.jtitle=Malaysian%20journal%20of%20pathology&rft.au=Elshebli,%20S&rft.date=2023-04&rft.volume=45&rft.issue=1&rft.spage=11&rft.epage=18&rft.pages=11-18&rft.issn=0126-8635&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E2807908543%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2829875506&rft_id=info:pmid/37119242&rfr_iscdi=true |