In vitro diagnostic testing for drug allergy in children
Diagnosing Drug Hypersensitivity Reactions (DHRs) could be a complicated process especially in children, since allergic‐like manifestation at this age is more often the expression of concomitant infections rather than a actual DHRs. In vivo tests are usually suggested as a first step; however, prick...
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| Veröffentlicht in: | Pediatric allergy and immunology 2023-04, Vol.34 (4), p.e13955-n/a |
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| container_title | Pediatric allergy and immunology |
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| creator | Saretta, Francesca Tomei, Leonardo Mori, Francesca Mayorga, Cristobalina |
| description | Diagnosing Drug Hypersensitivity Reactions (DHRs) could be a complicated process especially in children, since allergic‐like manifestation at this age is more often the expression of concomitant infections rather than a actual DHRs. In vivo tests are usually suggested as a first step; however, prick and intradermal tests could be painful and have shown different sensitivity and specificity among published studies. In some cases, in vivo tests such as Drug Provocation test (DPT) could be even contraindicated. Therefore, the need for in vitro testing is compelling, to add useful information along the diagnostic pathway and to limit the need of DPT. In this review, we analyze the different types of in vitro tests, focusing on those used more widely such as specific IgE and on those that are still for research settings, such as basophil activation test and lymphocyte transformation test, but that have shown some useful diagnostic potential. |
| doi_str_mv | 10.1111/pai.13955 |
| format | Article |
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In vivo tests are usually suggested as a first step; however, prick and intradermal tests could be painful and have shown different sensitivity and specificity among published studies. In some cases, in vivo tests such as Drug Provocation test (DPT) could be even contraindicated. Therefore, the need for in vitro testing is compelling, to add useful information along the diagnostic pathway and to limit the need of DPT. 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In vivo tests are usually suggested as a first step; however, prick and intradermal tests could be painful and have shown different sensitivity and specificity among published studies. In some cases, in vivo tests such as Drug Provocation test (DPT) could be even contraindicated. Therefore, the need for in vitro testing is compelling, to add useful information along the diagnostic pathway and to limit the need of DPT. In this review, we analyze the different types of in vitro tests, focusing on those used more widely such as specific IgE and on those that are still for research settings, such as basophil activation test and lymphocyte transformation test, but that have shown some useful diagnostic potential.</description><subject>Allergies</subject><subject>allergy</subject><subject>basophil activation test</subject><subject>Basophil Degranulation Test</subject><subject>Cell activation</subject><subject>Child</subject><subject>children</subject><subject>Diagnostic tests</subject><subject>drug allergy</subject><subject>drug hypersensitivity</subject><subject>Drug Hypersensitivity - diagnosis</subject><subject>Humans</subject><subject>Hypersensitivity - diagnosis</subject><subject>In Vitro Techniques</subject><subject>in vitro tests</subject><subject>Lymphocyte transformation</subject><subject>lymphocyte transformation test</subject><subject>Lymphocytes</subject><subject>Medical diagnosis</subject><subject>Sensitivity and Specificity</subject><subject>Side effects</subject><subject>Skin Tests</subject><subject>specific IgE</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10L1OwzAUBWALgWgpDLwAssQCQ9rr3DhOxqrip1IlGGC2nNgprtKk2A2ob49pCgMSd7nLp6OjQ8glgzELN9koO2aYc35EhuHnEQJmx2QIOfAoZVwMyJn3KwAmMGWnZICCQYw5DEk2b-iH3bqWaquWTeu3tqRbE16zpFXrqHbdkqq6Nm65o7ah5ZuttTPNOTmpVO3NxeGPyOv93cvsMVo8Pcxn00VUIkceodIAuspEWoBICpMgal6aUITHvIoFQmHiErPKGCW0QVEkSZzrQggWpwwKHJGbPnfj2vcuFJNr60tT16oxbedlnEGa56nIMNDrP3TVdq4J7fYqgZTnENRtr0rXeu9MJTfOrpXbSQbye04Z5pT7OYO9OiR2xdroX_mzXwCTHnza2uz-T5LP03kf-QXpCXyC</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Saretta, Francesca</creator><creator>Tomei, Leonardo</creator><creator>Mori, Francesca</creator><creator>Mayorga, Cristobalina</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7483-0128</orcidid><orcidid>https://orcid.org/0000-0001-9443-5483</orcidid></search><sort><creationdate>202304</creationdate><title>In vitro diagnostic testing for drug allergy in children</title><author>Saretta, Francesca ; Tomei, Leonardo ; Mori, Francesca ; Mayorga, Cristobalina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-3ad00df876b074be433d5ce173525f2730be2c38feea7de37b4429db7712610b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allergies</topic><topic>allergy</topic><topic>basophil activation test</topic><topic>Basophil Degranulation Test</topic><topic>Cell activation</topic><topic>Child</topic><topic>children</topic><topic>Diagnostic tests</topic><topic>drug allergy</topic><topic>drug hypersensitivity</topic><topic>Drug Hypersensitivity - diagnosis</topic><topic>Humans</topic><topic>Hypersensitivity - diagnosis</topic><topic>In Vitro Techniques</topic><topic>in vitro tests</topic><topic>Lymphocyte transformation</topic><topic>lymphocyte transformation test</topic><topic>Lymphocytes</topic><topic>Medical diagnosis</topic><topic>Sensitivity and Specificity</topic><topic>Side effects</topic><topic>Skin Tests</topic><topic>specific IgE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saretta, Francesca</creatorcontrib><creatorcontrib>Tomei, Leonardo</creatorcontrib><creatorcontrib>Mori, Francesca</creatorcontrib><creatorcontrib>Mayorga, Cristobalina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saretta, Francesca</au><au>Tomei, Leonardo</au><au>Mori, Francesca</au><au>Mayorga, Cristobalina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro diagnostic testing for drug allergy in children</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2023-04</date><risdate>2023</risdate><volume>34</volume><issue>4</issue><spage>e13955</spage><epage>n/a</epage><pages>e13955-n/a</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>Diagnosing Drug Hypersensitivity Reactions (DHRs) could be a complicated process especially in children, since allergic‐like manifestation at this age is more often the expression of concomitant infections rather than a actual DHRs. 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| subjects | Allergies allergy basophil activation test Basophil Degranulation Test Cell activation Child children Diagnostic tests drug allergy drug hypersensitivity Drug Hypersensitivity - diagnosis Humans Hypersensitivity - diagnosis In Vitro Techniques in vitro tests Lymphocyte transformation lymphocyte transformation test Lymphocytes Medical diagnosis Sensitivity and Specificity Side effects Skin Tests specific IgE |
| title | In vitro diagnostic testing for drug allergy in children |
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