Prefrontal microglia deficiency during adolescence disrupts adult cognitive functions and synaptic structures: A follow-up study in female mice

•Intracerebral CDS causes cell-specific, local and transient microglia depletion.•Prefrontal microglia depletion in adolescent female mice disrupts adult cognition.•Prefrontal microglia depletion in adolescent female mice impairs adult synapses.•Prefrontal microglia depletion in adult female mice ha...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2023-07, Vol.111, p.230-246
Hauptverfasser:	von Arx, Anina S., Dawson, Kara, Lin, Han-Yu, Mattei, Daniele, Notter, Tina, Meyer, Urs, Schalbetter, Sina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clodronate Cognition Cognitive functions Female Follow-Up Studies Male Microglia Microglia depletion Neurons - physiology Prefrontal Cortex Schizophrenia Sensitive periods Synaptic pruning
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