CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets

Altered intracellular Ca homeostasis in neonatal platelets has been previously reported. This study aims to examine the changes in the Ca entry through the store-operated calcium entry (SOCE) mechanism in neonatal platelets. Human platelets from either control women, mothers, and neonates were isola...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2023-05, Vol.43 (5), p.e151-e170
Hauptverfasser:	Berna-Erro, Alejandro, Ramesh, Girish, Delgado, Elena, Corbacho, Antonio J., Ferrer-Marín, Francisca, Teruel, Raul, Granados, María P., Rosado, Juan A., Redondo, Pedro C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - metabolism Calcium - metabolism Calcium Signaling Calpain - metabolism Female HEK293 Cells Humans Infant, Newborn Membrane Proteins - genetics Membrane Proteins - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism ORAI1 Protein - genetics ORAI1 Protein - metabolism Stromal Interaction Molecule 1 - genetics Stromal Interaction Molecule 1 - metabolism
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