Kidney medullary sodium chloride concentrations induce neutrophil and monocyte extracellular DNA traps that defend against pyelonephritis in vivo

Urinary tract infections are common. Here, we delineate a role of extracellular DNA trap (ET) formation in kidney antibacterial defense and determine mechanisms of their formation in the hyperosmotic environment of the kidney medulla. ET of granulocytic and monocytic origin were present in the kidne...

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Veröffentlicht in:	Kidney international 2023-08, Vol.104 (2), p.279-292
Hauptverfasser:	Goldspink, Adrian, Schmitz, Jessica, Babyak, Olena, Brauns, Nicolas, Milleck, Julia, Breloh, Anne M., Fleig, Susanne V., Jobin, Katarzyna, Schwarz, Lisa, Haller, Hermann, Wagenlehner, Florian, Bräsen, Jan Hinrich, Kurts, Christian, von Vietinghoff, Sibylle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium DNA Escherichia coli extracellular DNA traps Extracellular Traps Kidney Mice Monocytes NaCl Neutrophils pyelonephritis Pyelonephritis - drug therapy Sodium Chloride - pharmacology Urea
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