Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on a subset of macrophages at sites of SARS-CoV-2 infection in humans. Here, we investigated whether SARS-CoV-2 can enter macropha...

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Veröffentlicht in:	Science signaling 2023-04, Vol.16 (782), p.eabq1366-eabq1366
Hauptverfasser:	Labzin, Larisa I, Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J, Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E, Holley, Caroline L, Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L, Steinfort, Daniel P, Subbarao, Kanta, Nefzger, Christian M, Lagendijk, Anne K, Gordon, Emma J, Parton, Robert G, Short, Kirsty R, Londrigan, Sarah L, Schroder, Kate
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - genetics COVID-19 Cytokines Emergency response Humans Lungs Macrophages Macrophages - metabolism Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Viral diseases Virion - metabolism Virions
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