Pseudo-outbreak of Mycobacterium lentiflavum at a general hospital in Japan
is a slow-growing nontuberculous mycobacterium that is widely distributed in soil and water systems, but it is sometimes pathogenic to humans. Although cases of infections are rare, 22 isolates of were identified at a single hospital in Japan. We suspected a nosocomial outbreak; thus, we conducted t...
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| Veröffentlicht in: | Infection control and hospital epidemiology 2023-11, Vol.44 (11), p.1809-1815 |
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| creator | Nagano, Yutaro Kuronuma, Koji Kitamura, Yasuo Nagano, Kanami Yabe, Hayato Kudo, Sayaka Sato, Toyotaka Nirasawa, Shinya Nakae, Mami Horiuchi, Motohiro Yokota, Shin-ichi Fujiya, Yoshihiro Saito, Atsushi Takahashi, Satoshi Chiba, Hirofumi |
| description | is a slow-growing nontuberculous mycobacterium that is widely distributed in soil and water systems, but it is sometimes pathogenic to humans. Although cases of
infections are rare, 22 isolates of
were identified at a single hospital in Japan. We suspected a nosocomial outbreak; thus, we conducted transmission pattern and genotype analyses.
Cases of
isolated at Kushiro City General Hospital in Japan between May 2020 and April 2021 were analyzed. The patient samples and environmental culture specimens underwent whole-genome sequencing (WGS). Additionally, we retrospectively collected clinical data from patient medical records.
Altogether, 22 isolates of
were identified from sputum and bronchoalveolar lavage samples. Clinically, the instances with
isolates were considered contaminants. In the WGS analysis, 19 specimens, including 18 patient samples and 1 environmental culture from the hospital's faucet, showed genetic similarity. The frequency of
isolation decreased after we prohibited the use of taps where
was isolated.
WGS analysis identified that the cause of
pseudo-outbreak was the water used for patient examinations, including bronchoscopy. |
| doi_str_mv | 10.1017/ice.2023.68 |
| format | Article |
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infections are rare, 22 isolates of
were identified at a single hospital in Japan. We suspected a nosocomial outbreak; thus, we conducted transmission pattern and genotype analyses.
Cases of
isolated at Kushiro City General Hospital in Japan between May 2020 and April 2021 were analyzed. The patient samples and environmental culture specimens underwent whole-genome sequencing (WGS). Additionally, we retrospectively collected clinical data from patient medical records.
Altogether, 22 isolates of
were identified from sputum and bronchoalveolar lavage samples. Clinically, the instances with
isolates were considered contaminants. In the WGS analysis, 19 specimens, including 18 patient samples and 1 environmental culture from the hospital's faucet, showed genetic similarity. The frequency of
isolation decreased after we prohibited the use of taps where
was isolated.
WGS analysis identified that the cause of
pseudo-outbreak was the water used for patient examinations, including bronchoscopy.</description><identifier>ISSN: 0899-823X</identifier><identifier>EISSN: 1559-6834</identifier><identifier>DOI: 10.1017/ice.2023.68</identifier><identifier>PMID: 37096433</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Acids ; Automation ; Bacteria ; Contaminants ; Drinking water ; Emergency medical care ; Epidemics ; Genomes ; Hospitals ; Infections ; Lavage ; Medicine ; Nosocomial infection ; Original Article ; Outbreaks ; Outpatient care facilities ; Patients ; Spectrum analysis ; Water quality ; Water supply</subject><ispartof>Infection control and hospital epidemiology, 2023-11, Vol.44 (11), p.1809-1815</ispartof><rights>The Author(s), 2023. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America</rights><rights>The Author(s), 2023. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America. This work is licensed under the Creative Commons Attribution – Non-Commercial – No Derivatives License This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article. (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c350t-e4ed708be0aa7fc0208c3ce87de0dc522f0b633baadfcb6ca13fd3752bab43cc3</cites><orcidid>0000-0003-3430-884X ; 0000-0002-0831-3429 ; 0000-0002-2743-3266</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2892292123/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2892292123?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>164,315,781,785,21393,21394,23261,27929,27930,33535,33536,33708,33709,33749,33750,43664,43792,43810,55633,64390,64392,64394,72474,74109,74288,74307</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37096433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagano, Yutaro</creatorcontrib><creatorcontrib>Kuronuma, Koji</creatorcontrib><creatorcontrib>Kitamura, Yasuo</creatorcontrib><creatorcontrib>Nagano, Kanami</creatorcontrib><creatorcontrib>Yabe, Hayato</creatorcontrib><creatorcontrib>Kudo, Sayaka</creatorcontrib><creatorcontrib>Sato, Toyotaka</creatorcontrib><creatorcontrib>Nirasawa, Shinya</creatorcontrib><creatorcontrib>Nakae, Mami</creatorcontrib><creatorcontrib>Horiuchi, Motohiro</creatorcontrib><creatorcontrib>Yokota, Shin-ichi</creatorcontrib><creatorcontrib>Fujiya, Yoshihiro</creatorcontrib><creatorcontrib>Saito, Atsushi</creatorcontrib><creatorcontrib>Takahashi, Satoshi</creatorcontrib><creatorcontrib>Chiba, Hirofumi</creatorcontrib><title>Pseudo-outbreak of Mycobacterium lentiflavum at a general hospital in Japan</title><title>Infection control and hospital epidemiology</title><addtitle>Infect. Control Hosp. Epidemiol</addtitle><description>is a slow-growing nontuberculous mycobacterium that is widely distributed in soil and water systems, but it is sometimes pathogenic to humans. Although cases of
infections are rare, 22 isolates of
were identified at a single hospital in Japan. We suspected a nosocomial outbreak; thus, we conducted transmission pattern and genotype analyses.
Cases of
isolated at Kushiro City General Hospital in Japan between May 2020 and April 2021 were analyzed. The patient samples and environmental culture specimens underwent whole-genome sequencing (WGS). Additionally, we retrospectively collected clinical data from patient medical records.
Altogether, 22 isolates of
were identified from sputum and bronchoalveolar lavage samples. Clinically, the instances with
isolates were considered contaminants. In the WGS analysis, 19 specimens, including 18 patient samples and 1 environmental culture from the hospital's faucet, showed genetic similarity. The frequency of
isolation decreased after we prohibited the use of taps where
was isolated.
WGS analysis identified that the cause of
pseudo-outbreak was the water used for patient examinations, including bronchoscopy.</description><subject>Acids</subject><subject>Automation</subject><subject>Bacteria</subject><subject>Contaminants</subject><subject>Drinking water</subject><subject>Emergency medical care</subject><subject>Epidemics</subject><subject>Genomes</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Lavage</subject><subject>Medicine</subject><subject>Nosocomial infection</subject><subject>Original Article</subject><subject>Outbreaks</subject><subject>Outpatient care facilities</subject><subject>Patients</subject><subject>Spectrum analysis</subject><subject>Water quality</subject><subject>Water supply</subject><issn>0899-823X</issn><issn>1559-6834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>IKXGN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkE1Lw0AQhhdRbK2evEvAiyCpk93mY49S_Fb0oOAtzG4mNTXJ1t1E6L93S6uCeJr38PDOzMPYYQTjCKL0rNI05sDFOMm22DCKYxkmmZhssyFkUoYZF68DtufcHABSKaNdNhApyGQixJDdPTnqCxOavlOW8D0wZfCw1Eah7shWfRPU1HZVWeOnz9gFGMyoJYt18Gbcoup8qNrgFhfY7rOdEmtHB5s5Yi-XF8_T6_D-8epmen4fahFDF9KEihQyRYCYlho4ZFpoytKCoNAx5yWoRAiFWJRaJRojURYijblCNRFaixE7WfcurPnoyXV5UzlNdY0tmd7lPIMEEul_9ejxH3Ruetv66zwlOZc84sJTp2tKW-OcpTJf2KpBu8wjyFeOc-84XznOvdkRO9p09qqh4of9luqBcFOHjbJVMaPfrf8VfgFoGIb6</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Nagano, Yutaro</creator><creator>Kuronuma, Koji</creator><creator>Kitamura, Yasuo</creator><creator>Nagano, Kanami</creator><creator>Yabe, Hayato</creator><creator>Kudo, Sayaka</creator><creator>Sato, Toyotaka</creator><creator>Nirasawa, Shinya</creator><creator>Nakae, Mami</creator><creator>Horiuchi, Motohiro</creator><creator>Yokota, Shin-ichi</creator><creator>Fujiya, Yoshihiro</creator><creator>Saito, Atsushi</creator><creator>Takahashi, Satoshi</creator><creator>Chiba, Hirofumi</creator><general>Cambridge University Press</general><scope>IKXGN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>S0X</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3430-884X</orcidid><orcidid>https://orcid.org/0000-0002-0831-3429</orcidid><orcidid>https://orcid.org/0000-0002-2743-3266</orcidid></search><sort><creationdate>20231101</creationdate><title>Pseudo-outbreak of Mycobacterium lentiflavum at a general hospital in Japan</title><author>Nagano, Yutaro ; 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Control Hosp. Epidemiol</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>44</volume><issue>11</issue><spage>1809</spage><epage>1815</epage><pages>1809-1815</pages><issn>0899-823X</issn><eissn>1559-6834</eissn><abstract>is a slow-growing nontuberculous mycobacterium that is widely distributed in soil and water systems, but it is sometimes pathogenic to humans. Although cases of
infections are rare, 22 isolates of
were identified at a single hospital in Japan. We suspected a nosocomial outbreak; thus, we conducted transmission pattern and genotype analyses.
Cases of
isolated at Kushiro City General Hospital in Japan between May 2020 and April 2021 were analyzed. The patient samples and environmental culture specimens underwent whole-genome sequencing (WGS). Additionally, we retrospectively collected clinical data from patient medical records.
Altogether, 22 isolates of
were identified from sputum and bronchoalveolar lavage samples. Clinically, the instances with
isolates were considered contaminants. In the WGS analysis, 19 specimens, including 18 patient samples and 1 environmental culture from the hospital's faucet, showed genetic similarity. The frequency of
isolation decreased after we prohibited the use of taps where
was isolated.
WGS analysis identified that the cause of
pseudo-outbreak was the water used for patient examinations, including bronchoscopy.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>37096433</pmid><doi>10.1017/ice.2023.68</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3430-884X</orcidid><orcidid>https://orcid.org/0000-0002-0831-3429</orcidid><orcidid>https://orcid.org/0000-0002-2743-3266</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Automation Bacteria Contaminants Drinking water Emergency medical care Epidemics Genomes Hospitals Infections Lavage Medicine Nosocomial infection Original Article Outbreaks Outpatient care facilities Patients Spectrum analysis Water quality Water supply |
| title | Pseudo-outbreak of Mycobacterium lentiflavum at a general hospital in Japan |
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