Advanced lipoprotein profile identifies atherosclerosis better than conventional lipids in type 1 diabetes at high cardiovascular risk
People with type 1 diabetes (T1D) present lipoprotein disturbances that could contribute to their increased cardiovascular disease (CVD) risk. We evaluated the relationship between lipoprotein alterations and atherosclerosis in patients with T1D. Cross-sectional study in subjects with T1D, without p...
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| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2023-06, Vol.33 (6), p.1235-1244 |
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| creator | Serés-Noriega, Tonet Ortega, Emilio Giménez, Marga Perea, Verónica Boswell, Laura Mariaca, Karla Font, Carla Mesa, Alex Viñals, Clara Blanco, Jesús Vinagre, Irene Pané, Adriana Esmatjes, Enric Conget, Ignacio Amor, Antonio J. |
| description | People with type 1 diabetes (T1D) present lipoprotein disturbances that could contribute to their increased cardiovascular disease (CVD) risk. We evaluated the relationship between lipoprotein alterations and atherosclerosis in patients with T1D.
Cross-sectional study in subjects with T1D, without previous CVD, but high-risk (≥40 years, nephropathy, or ≥10 years of evolution of diabetes with another risk factor). The presence of plaque (intima-media thickness ≥1.5 mm) in the different carotid segments was determined by ultrasound. The advanced lipoprotein profile was analysed by magnetic resonance imaging (1H NMR). We included 189 patients (42% women, 47.8 ± 10.7 years, duration of diabetes 27.3 ± 10.1 years, HbA1c 7.5% [7–8]). Those with carotid plaques (35%) were older, with longer diabetes duration, had a higher prevalence of hypertension, and showed lower and smaller LDL particles (LDL-P) and HDL particles (HDL-P), but higher VLDL particles (VLDL-P). Some LDL, HDL and VLDL-related parameters were associated with atherosclerosis in sex, age and statin use adjusted models (p |
| doi_str_mv | 10.1016/j.numecd.2023.03.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2805519776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0939475323001448</els_id><sourcerecordid>2834222749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c395t-1864bf7cc52ea80044fee431a5ded417a8ef906520811043a9fc00b1f7ab5d923</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0Eokvbf4CQj1yyjL_i-IJUVXxJlXopZ8uxJ6yXbLLYzkr9A_xuHLZwREijeS_PvKOZl5DXDLYMWPtuv52WA_qw5cDFFmpx9YxsmDLQCM3Nc7IBI0wjtRIX5FXOewChQciX5KJq17WKbcjPm3Byk8dAx3icj2kuGCdadYgj0hhwKnGImKkrO0xz9uPaY6Y9loKJlp2bqJ-n0wrOkxtXnxgyrS7l8YiU0RBdhX9b0F38tqPepRDnk8t-GV2iKebvV-TF4MaM1096Sb5-_PBw-7m5u__05fbmrvHCqNKwrpX9oL1XHF0HIOWAKAVzKmCQTLsOBwOt4tAxBlI4M3iAng3a9SoYLi7J27NvvfDHgrnYQ8wex9FNOC_Z8k5IzrmW5j9QUIoZrduKyjPq629ywsEeUzy49GgZ2DUsu7fnsOwaloVaXNWxN08blv6A4e_Qn3Qq8P4MYH3JKWKy2Udc04oJfbFhjv_e8AsI9aoz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2805519776</pqid></control><display><type>article</type><title>Advanced lipoprotein profile identifies atherosclerosis better than conventional lipids in type 1 diabetes at high cardiovascular risk</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Serés-Noriega, Tonet ; Ortega, Emilio ; Giménez, Marga ; Perea, Verónica ; Boswell, Laura ; Mariaca, Karla ; Font, Carla ; Mesa, Alex ; Viñals, Clara ; Blanco, Jesús ; Vinagre, Irene ; Pané, Adriana ; Esmatjes, Enric ; Conget, Ignacio ; Amor, Antonio J.</creator><creatorcontrib>Serés-Noriega, Tonet ; Ortega, Emilio ; Giménez, Marga ; Perea, Verónica ; Boswell, Laura ; Mariaca, Karla ; Font, Carla ; Mesa, Alex ; Viñals, Clara ; Blanco, Jesús ; Vinagre, Irene ; Pané, Adriana ; Esmatjes, Enric ; Conget, Ignacio ; Amor, Antonio J.</creatorcontrib><description>People with type 1 diabetes (T1D) present lipoprotein disturbances that could contribute to their increased cardiovascular disease (CVD) risk. We evaluated the relationship between lipoprotein alterations and atherosclerosis in patients with T1D.
Cross-sectional study in subjects with T1D, without previous CVD, but high-risk (≥40 years, nephropathy, or ≥10 years of evolution of diabetes with another risk factor). The presence of plaque (intima-media thickness ≥1.5 mm) in the different carotid segments was determined by ultrasound. The advanced lipoprotein profile was analysed by magnetic resonance imaging (1H NMR). We included 189 patients (42% women, 47.8 ± 10.7 years, duration of diabetes 27.3 ± 10.1 years, HbA1c 7.5% [7–8]). Those with carotid plaques (35%) were older, with longer diabetes duration, had a higher prevalence of hypertension, and showed lower and smaller LDL particles (LDL-P) and HDL particles (HDL-P), but higher VLDL particles (VLDL-P). Some LDL, HDL and VLDL-related parameters were associated with atherosclerosis in sex, age and statin use adjusted models (p < 0.05), but after adjusting for multiple confounders, including conventional lipid parameters, only HDL-P (OR 0.440 [0.204–0.951]; p = 0.037), medium HDL-P (OR 0.754 [0.590–0.963]; p = 0.024), HDL-P cholesterol content (OR 0.692 [0.495–0.968]; p = 0.032), 1H NMR LDL-P number/conventional LDL-cholesterol (OR 1.144 [1.026–1.275]; p = 0.015), and 1H NMR non-HDL particle number/conventional non-HDL-cholesterol ratios (OR 1.178 [1.019–1.361], p = 0.026) remained associated with atherosclerosis.
In adults with T1D at high-risk, variables related to HDL, LDL and total atherogenic particle number are independently associated with preclinical atherosclerosis. Advanced lipoprotein profiling could be used to identify those at the highest risk of CVD.
[Display omitted]
•People with type 1 diabetes show detrimental lipoprotein subclass disturbances.•A worse NMR-assessed lipoprotein profile is present if atherosclerosis coexists.•Some advanced LDL and HDL-related parameters are associated with carotid plaques.•The associations were independent of other variables, including conventional lipids.•The advanced lipoprotein profile can identify those with higher cardiovascular risk.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2023.03.025</identifier><identifier>PMID: 37088651</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Advanced lipoprotein ; Atherosclerosis ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - epidemiology ; Cardiovascular Diseases - diagnostic imaging ; Cardiovascular Diseases - epidemiology ; Cardiovascular risk ; Carotid Intima-Media Thickness ; Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetes Mellitus, Type 1 - epidemiology ; evolution ; Female ; Heart Disease Risk Factors ; Humans ; hypertension ; insulin-dependent diabetes mellitus ; kidney diseases ; LDL particles ; Lipoprotein subclasses ; Lipoproteins ; low density lipoprotein cholesterol ; magnetism ; Male ; metabolism ; Nuclear magnetic resonance ; nutrition ; Plaque, Atherosclerotic ; Risk Factors ; Type 1 diabetes ; ultrasonics ; Ultrasound</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2023-06, Vol.33 (6), p.1235-1244</ispartof><rights>2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-1864bf7cc52ea80044fee431a5ded417a8ef906520811043a9fc00b1f7ab5d923</citedby><cites>FETCH-LOGICAL-c395t-1864bf7cc52ea80044fee431a5ded417a8ef906520811043a9fc00b1f7ab5d923</cites><orcidid>0000-0001-8104-7326 ; 0000-0002-6888-0396 ; 0000-0003-0696-2529 ; 0000-0001-6459-5566 ; 0000-0001-9237-0903 ; 0000-0003-4974-0969 ; 0000-0002-7810-1827 ; 0000-0002-8553-4030</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475323001448$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37088651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serés-Noriega, Tonet</creatorcontrib><creatorcontrib>Ortega, Emilio</creatorcontrib><creatorcontrib>Giménez, Marga</creatorcontrib><creatorcontrib>Perea, Verónica</creatorcontrib><creatorcontrib>Boswell, Laura</creatorcontrib><creatorcontrib>Mariaca, Karla</creatorcontrib><creatorcontrib>Font, Carla</creatorcontrib><creatorcontrib>Mesa, Alex</creatorcontrib><creatorcontrib>Viñals, Clara</creatorcontrib><creatorcontrib>Blanco, Jesús</creatorcontrib><creatorcontrib>Vinagre, Irene</creatorcontrib><creatorcontrib>Pané, Adriana</creatorcontrib><creatorcontrib>Esmatjes, Enric</creatorcontrib><creatorcontrib>Conget, Ignacio</creatorcontrib><creatorcontrib>Amor, Antonio J.</creatorcontrib><title>Advanced lipoprotein profile identifies atherosclerosis better than conventional lipids in type 1 diabetes at high cardiovascular risk</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>People with type 1 diabetes (T1D) present lipoprotein disturbances that could contribute to their increased cardiovascular disease (CVD) risk. We evaluated the relationship between lipoprotein alterations and atherosclerosis in patients with T1D.
Cross-sectional study in subjects with T1D, without previous CVD, but high-risk (≥40 years, nephropathy, or ≥10 years of evolution of diabetes with another risk factor). The presence of plaque (intima-media thickness ≥1.5 mm) in the different carotid segments was determined by ultrasound. The advanced lipoprotein profile was analysed by magnetic resonance imaging (1H NMR). We included 189 patients (42% women, 47.8 ± 10.7 years, duration of diabetes 27.3 ± 10.1 years, HbA1c 7.5% [7–8]). Those with carotid plaques (35%) were older, with longer diabetes duration, had a higher prevalence of hypertension, and showed lower and smaller LDL particles (LDL-P) and HDL particles (HDL-P), but higher VLDL particles (VLDL-P). Some LDL, HDL and VLDL-related parameters were associated with atherosclerosis in sex, age and statin use adjusted models (p < 0.05), but after adjusting for multiple confounders, including conventional lipid parameters, only HDL-P (OR 0.440 [0.204–0.951]; p = 0.037), medium HDL-P (OR 0.754 [0.590–0.963]; p = 0.024), HDL-P cholesterol content (OR 0.692 [0.495–0.968]; p = 0.032), 1H NMR LDL-P number/conventional LDL-cholesterol (OR 1.144 [1.026–1.275]; p = 0.015), and 1H NMR non-HDL particle number/conventional non-HDL-cholesterol ratios (OR 1.178 [1.019–1.361], p = 0.026) remained associated with atherosclerosis.
In adults with T1D at high-risk, variables related to HDL, LDL and total atherogenic particle number are independently associated with preclinical atherosclerosis. Advanced lipoprotein profiling could be used to identify those at the highest risk of CVD.
[Display omitted]
•People with type 1 diabetes show detrimental lipoprotein subclass disturbances.•A worse NMR-assessed lipoprotein profile is present if atherosclerosis coexists.•Some advanced LDL and HDL-related parameters are associated with carotid plaques.•The associations were independent of other variables, including conventional lipids.•The advanced lipoprotein profile can identify those with higher cardiovascular risk.</description><subject>Adult</subject><subject>Advanced lipoprotein</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Atherosclerosis - epidemiology</subject><subject>Cardiovascular Diseases - diagnostic imaging</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular risk</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL</subject><subject>Cholesterol, LDL</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>evolution</subject><subject>Female</subject><subject>Heart Disease Risk Factors</subject><subject>Humans</subject><subject>hypertension</subject><subject>insulin-dependent diabetes mellitus</subject><subject>kidney diseases</subject><subject>LDL particles</subject><subject>Lipoprotein subclasses</subject><subject>Lipoproteins</subject><subject>low density lipoprotein cholesterol</subject><subject>magnetism</subject><subject>Male</subject><subject>metabolism</subject><subject>Nuclear magnetic resonance</subject><subject>nutrition</subject><subject>Plaque, Atherosclerotic</subject><subject>Risk Factors</subject><subject>Type 1 diabetes</subject><subject>ultrasonics</subject><subject>Ultrasound</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0Eokvbf4CQj1yyjL_i-IJUVXxJlXopZ8uxJ6yXbLLYzkr9A_xuHLZwREijeS_PvKOZl5DXDLYMWPtuv52WA_qw5cDFFmpx9YxsmDLQCM3Nc7IBI0wjtRIX5FXOewChQciX5KJq17WKbcjPm3Byk8dAx3icj2kuGCdadYgj0hhwKnGImKkrO0xz9uPaY6Y9loKJlp2bqJ-n0wrOkxtXnxgyrS7l8YiU0RBdhX9b0F38tqPepRDnk8t-GV2iKebvV-TF4MaM1096Sb5-_PBw-7m5u__05fbmrvHCqNKwrpX9oL1XHF0HIOWAKAVzKmCQTLsOBwOt4tAxBlI4M3iAng3a9SoYLi7J27NvvfDHgrnYQ8wex9FNOC_Z8k5IzrmW5j9QUIoZrduKyjPq629ywsEeUzy49GgZ2DUsu7fnsOwaloVaXNWxN08blv6A4e_Qn3Qq8P4MYH3JKWKy2Udc04oJfbFhjv_e8AsI9aoz</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Serés-Noriega, Tonet</creator><creator>Ortega, Emilio</creator><creator>Giménez, Marga</creator><creator>Perea, Verónica</creator><creator>Boswell, Laura</creator><creator>Mariaca, Karla</creator><creator>Font, Carla</creator><creator>Mesa, Alex</creator><creator>Viñals, Clara</creator><creator>Blanco, Jesús</creator><creator>Vinagre, Irene</creator><creator>Pané, Adriana</creator><creator>Esmatjes, Enric</creator><creator>Conget, Ignacio</creator><creator>Amor, Antonio J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-8104-7326</orcidid><orcidid>https://orcid.org/0000-0002-6888-0396</orcidid><orcidid>https://orcid.org/0000-0003-0696-2529</orcidid><orcidid>https://orcid.org/0000-0001-6459-5566</orcidid><orcidid>https://orcid.org/0000-0001-9237-0903</orcidid><orcidid>https://orcid.org/0000-0003-4974-0969</orcidid><orcidid>https://orcid.org/0000-0002-7810-1827</orcidid><orcidid>https://orcid.org/0000-0002-8553-4030</orcidid></search><sort><creationdate>20230601</creationdate><title>Advanced lipoprotein profile identifies atherosclerosis better than conventional lipids in type 1 diabetes at high cardiovascular risk</title><author>Serés-Noriega, Tonet ; Ortega, Emilio ; Giménez, Marga ; Perea, Verónica ; Boswell, Laura ; Mariaca, Karla ; Font, Carla ; Mesa, Alex ; Viñals, Clara ; Blanco, Jesús ; Vinagre, Irene ; Pané, Adriana ; Esmatjes, Enric ; Conget, Ignacio ; Amor, Antonio J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-1864bf7cc52ea80044fee431a5ded417a8ef906520811043a9fc00b1f7ab5d923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Advanced lipoprotein</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Atherosclerosis - epidemiology</topic><topic>Cardiovascular Diseases - diagnostic imaging</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular risk</topic><topic>Carotid Intima-Media Thickness</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL</topic><topic>Cholesterol, LDL</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - diagnosis</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>evolution</topic><topic>Female</topic><topic>Heart Disease Risk Factors</topic><topic>Humans</topic><topic>hypertension</topic><topic>insulin-dependent diabetes mellitus</topic><topic>kidney diseases</topic><topic>LDL particles</topic><topic>Lipoprotein subclasses</topic><topic>Lipoproteins</topic><topic>low density lipoprotein cholesterol</topic><topic>magnetism</topic><topic>Male</topic><topic>metabolism</topic><topic>Nuclear magnetic resonance</topic><topic>nutrition</topic><topic>Plaque, Atherosclerotic</topic><topic>Risk Factors</topic><topic>Type 1 diabetes</topic><topic>ultrasonics</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serés-Noriega, Tonet</creatorcontrib><creatorcontrib>Ortega, Emilio</creatorcontrib><creatorcontrib>Giménez, Marga</creatorcontrib><creatorcontrib>Perea, Verónica</creatorcontrib><creatorcontrib>Boswell, Laura</creatorcontrib><creatorcontrib>Mariaca, Karla</creatorcontrib><creatorcontrib>Font, Carla</creatorcontrib><creatorcontrib>Mesa, Alex</creatorcontrib><creatorcontrib>Viñals, Clara</creatorcontrib><creatorcontrib>Blanco, Jesús</creatorcontrib><creatorcontrib>Vinagre, Irene</creatorcontrib><creatorcontrib>Pané, Adriana</creatorcontrib><creatorcontrib>Esmatjes, Enric</creatorcontrib><creatorcontrib>Conget, Ignacio</creatorcontrib><creatorcontrib>Amor, Antonio J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serés-Noriega, Tonet</au><au>Ortega, Emilio</au><au>Giménez, Marga</au><au>Perea, Verónica</au><au>Boswell, Laura</au><au>Mariaca, Karla</au><au>Font, Carla</au><au>Mesa, Alex</au><au>Viñals, Clara</au><au>Blanco, Jesús</au><au>Vinagre, Irene</au><au>Pané, Adriana</au><au>Esmatjes, Enric</au><au>Conget, Ignacio</au><au>Amor, Antonio J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced lipoprotein profile identifies atherosclerosis better than conventional lipids in type 1 diabetes at high cardiovascular risk</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>33</volume><issue>6</issue><spage>1235</spage><epage>1244</epage><pages>1235-1244</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>People with type 1 diabetes (T1D) present lipoprotein disturbances that could contribute to their increased cardiovascular disease (CVD) risk. We evaluated the relationship between lipoprotein alterations and atherosclerosis in patients with T1D.
Cross-sectional study in subjects with T1D, without previous CVD, but high-risk (≥40 years, nephropathy, or ≥10 years of evolution of diabetes with another risk factor). The presence of plaque (intima-media thickness ≥1.5 mm) in the different carotid segments was determined by ultrasound. The advanced lipoprotein profile was analysed by magnetic resonance imaging (1H NMR). We included 189 patients (42% women, 47.8 ± 10.7 years, duration of diabetes 27.3 ± 10.1 years, HbA1c 7.5% [7–8]). Those with carotid plaques (35%) were older, with longer diabetes duration, had a higher prevalence of hypertension, and showed lower and smaller LDL particles (LDL-P) and HDL particles (HDL-P), but higher VLDL particles (VLDL-P). Some LDL, HDL and VLDL-related parameters were associated with atherosclerosis in sex, age and statin use adjusted models (p < 0.05), but after adjusting for multiple confounders, including conventional lipid parameters, only HDL-P (OR 0.440 [0.204–0.951]; p = 0.037), medium HDL-P (OR 0.754 [0.590–0.963]; p = 0.024), HDL-P cholesterol content (OR 0.692 [0.495–0.968]; p = 0.032), 1H NMR LDL-P number/conventional LDL-cholesterol (OR 1.144 [1.026–1.275]; p = 0.015), and 1H NMR non-HDL particle number/conventional non-HDL-cholesterol ratios (OR 1.178 [1.019–1.361], p = 0.026) remained associated with atherosclerosis.
In adults with T1D at high-risk, variables related to HDL, LDL and total atherogenic particle number are independently associated with preclinical atherosclerosis. Advanced lipoprotein profiling could be used to identify those at the highest risk of CVD.
[Display omitted]
•People with type 1 diabetes show detrimental lipoprotein subclass disturbances.•A worse NMR-assessed lipoprotein profile is present if atherosclerosis coexists.•Some advanced LDL and HDL-related parameters are associated with carotid plaques.•The associations were independent of other variables, including conventional lipids.•The advanced lipoprotein profile can identify those with higher cardiovascular risk.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37088651</pmid><doi>10.1016/j.numecd.2023.03.025</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8104-7326</orcidid><orcidid>https://orcid.org/0000-0002-6888-0396</orcidid><orcidid>https://orcid.org/0000-0003-0696-2529</orcidid><orcidid>https://orcid.org/0000-0001-6459-5566</orcidid><orcidid>https://orcid.org/0000-0001-9237-0903</orcidid><orcidid>https://orcid.org/0000-0003-4974-0969</orcidid><orcidid>https://orcid.org/0000-0002-7810-1827</orcidid><orcidid>https://orcid.org/0000-0002-8553-4030</orcidid></addata></record> |
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| ispartof | Nutrition, metabolism, and cardiovascular diseases, 2023-06, Vol.33 (6), p.1235-1244 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Advanced lipoprotein Atherosclerosis Atherosclerosis - diagnostic imaging Atherosclerosis - epidemiology Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - epidemiology Cardiovascular risk Carotid Intima-Media Thickness Cholesterol Cholesterol, HDL Cholesterol, LDL Cross-Sectional Studies Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - epidemiology evolution Female Heart Disease Risk Factors Humans hypertension insulin-dependent diabetes mellitus kidney diseases LDL particles Lipoprotein subclasses Lipoproteins low density lipoprotein cholesterol magnetism Male metabolism Nuclear magnetic resonance nutrition Plaque, Atherosclerotic Risk Factors Type 1 diabetes ultrasonics Ultrasound |
| title | Advanced lipoprotein profile identifies atherosclerosis better than conventional lipids in type 1 diabetes at high cardiovascular risk |
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