Polyphyllin D-loaded solid lipid nanoparticles for breast cancer: Synthesis, characterization, in vitro, and in vivo studies

[Display omitted] Polyphyllin D (PD), a steroidal saponin in Paris polyphylla, induces apoptosis via the intrinsic apoptotic pathway in different cancer types. However, emerging evidence has shown that the primary issue with PD is its structure's hemolysis and cytotoxicity. This study aimed to...

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Veröffentlicht in:	International journal of pharmaceutics 2023-05, Vol.639, p.122976-122976, Article 122976
Hauptverfasser:	Emami, Azadeh, Ghafouri, Hossein, Sariri, Reyhaneh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Breast cancer Cell Line, Tumor Mice Nanoparticles Neoplasms Polyphyllin D Saponins - pharmacology Solid lipid nanoparticles Tumor Suppressor Protein p53
Online-Zugang:	Volltext
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