Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and peroxisomes

Mitochondrial dysfunction and aberrant structure in adipose tissue occur in obesity and obesity-linked brown adipose tissue (BAT) whitening; however, whether this aberrant architecture contributes to or is the result of obesity is unknown. Apolipoprotein O (APOO) is a constitutive protein of the mit...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2023-07, Vol.144, p.155564-155564, Article 155564
Hauptverfasser:	Guo, Xin, Hu, Jiarui, He, Guangxu, Chen, Jin, Yang, Yang, Qin, Donglu, Li, Chenyu, Huang, Zhijie, Hu, Die, Wei, Cheng, Wang, Fengjiao, Yu, Bilian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes, Brown - metabolism Adipose Tissue, Brown - metabolism Animals APOO BAT whitening Brown adipose tissue Fatty acid oxidation Fatty Acids - metabolism Humans Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - metabolism Obesity Obesity - metabolism Peroxisomes - metabolism PPAR alpha - metabolism Thermogenesis
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