Decrease in CD226 expression on CD4+ T cells in patients with endometriosis
Endometriosis is a chronic inflammatory disease. The immune-checkpoint molecules CD226 and TIGIT play an important role in regulating T cells' function. However, little is known about the proportion and function of CD226 and TIGIT on CD4+ T cells in endometriosis. The current study found no sig...
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| Veröffentlicht in: | BioScience Trends 2023/04/30, Vol.17(2), pp.168-171 |
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| creator | Li, Cui Zhou, Jing Shao, Jun Yuan, Lei Cheng, Qiang Wang, Ling Duan, Zhongliang |
| description | Endometriosis is a chronic inflammatory disease. The immune-checkpoint molecules CD226 and TIGIT play an important role in regulating T cells' function. However, little is known about the proportion and function of CD226 and TIGIT on CD4+ T cells in endometriosis. The current study found no significant differences in the TIGIT percentage on peripheral CD4+ T cells between patients with endometriosis and the control group. However, CD226 was lower in patients with endometriosis than that in the control group (P < 0.01). The cytokines TNF-α, IL10, and IFN-γ were significantly elevated in TIGIT+ CD4+ T cells compared to TIGIT- CD4+ T cells. HLA-DR+ cells were more numerous among TIGIT+ CD4+ T cells than among the TIGIT- subset (P |
| doi_str_mv | 10.5582/bst.2022.01501 |
| format | Article |
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The immune-checkpoint molecules CD226 and TIGIT play an important role in regulating T cells' function. However, little is known about the proportion and function of CD226 and TIGIT on CD4+ T cells in endometriosis. The current study found no significant differences in the TIGIT percentage on peripheral CD4+ T cells between patients with endometriosis and the control group. However, CD226 was lower in patients with endometriosis than that in the control group (P < 0.01). The cytokines TNF-α, IL10, and IFN-γ were significantly elevated in TIGIT+ CD4+ T cells compared to TIGIT- CD4+ T cells. HLA-DR+ cells were more numerous among TIGIT+ CD4+ T cells than among the TIGIT- subset (P <0.001). Similarly, the cytokines TNF-α, IL10, and IFN-γ were significantly elevated in CD226+ CD4+ T cells compared to levels in CD226- CD4+ T cells. The proportion of HLA-DR+ CD4+ T cells among CD226+ CD4+ T cells was also significantly higher than that among the CD226- subset (P < 0.001). After TIGIT was blocked, the level of IL-10 in TIGIT+ CD4+ T cells was higher than that in cells with unblocked TIGIT. There were no differences in TNF-α and IFN-γ. After CD226 was blocked, TNF-α and IFN-γwere lower while IL-10 was higher. In conclusion, there is a diminution of CD226 in CD4+ T cells in patients with endometriosis. This is correlated with the effector function of CD4+ T cells, and blocking CD226 can suppress this function.</description><identifier>ISSN: 1881-7815</identifier><identifier>EISSN: 1881-7823</identifier><identifier>DOI: 10.5582/bst.2022.01501</identifier><identifier>PMID: 37081668</identifier><language>eng</language><publisher>Japan: International Research and Cooperation Association for Bio & Socio-Sciences Advancement</publisher><subject>Antigens, Differentiation, T-Lymphocyte - metabolism ; CD226 ; CD4+ T cells ; CD4-Positive T-Lymphocytes - metabolism ; Cytokines - metabolism ; endometriosis ; Endometriosis - metabolism ; Female ; Humans ; Interleukin-10 - metabolism ; Receptors, Immunologic ; TIGIT ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>BioScience Trends, 2023/04/30, Vol.17(2), pp.168-171</ispartof><rights>2023 International Research and Cooperation Association for Bio & Socio-Sciences Advancement</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-9aa4ed11c86da8449dda35b324e20c8d41c8703d159a9730c355080be6455523</citedby><cites>FETCH-LOGICAL-c486t-9aa4ed11c86da8449dda35b324e20c8d41c8703d159a9730c355080be6455523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37081668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Cui</creatorcontrib><creatorcontrib>Zhou, Jing</creatorcontrib><creatorcontrib>Shao, Jun</creatorcontrib><creatorcontrib>Yuan, Lei</creatorcontrib><creatorcontrib>Cheng, Qiang</creatorcontrib><creatorcontrib>Wang, Ling</creatorcontrib><creatorcontrib>Duan, Zhongliang</creatorcontrib><title>Decrease in CD226 expression on CD4+ T cells in patients with endometriosis</title><title>BioScience Trends</title><addtitle>BST</addtitle><description>Endometriosis is a chronic inflammatory disease. The immune-checkpoint molecules CD226 and TIGIT play an important role in regulating T cells' function. However, little is known about the proportion and function of CD226 and TIGIT on CD4+ T cells in endometriosis. The current study found no significant differences in the TIGIT percentage on peripheral CD4+ T cells between patients with endometriosis and the control group. However, CD226 was lower in patients with endometriosis than that in the control group (P < 0.01). The cytokines TNF-α, IL10, and IFN-γ were significantly elevated in TIGIT+ CD4+ T cells compared to TIGIT- CD4+ T cells. HLA-DR+ cells were more numerous among TIGIT+ CD4+ T cells than among the TIGIT- subset (P <0.001). Similarly, the cytokines TNF-α, IL10, and IFN-γ were significantly elevated in CD226+ CD4+ T cells compared to levels in CD226- CD4+ T cells. The proportion of HLA-DR+ CD4+ T cells among CD226+ CD4+ T cells was also significantly higher than that among the CD226- subset (P < 0.001). After TIGIT was blocked, the level of IL-10 in TIGIT+ CD4+ T cells was higher than that in cells with unblocked TIGIT. There were no differences in TNF-α and IFN-γ. After CD226 was blocked, TNF-α and IFN-γwere lower while IL-10 was higher. In conclusion, there is a diminution of CD226 in CD4+ T cells in patients with endometriosis. This is correlated with the effector function of CD4+ T cells, and blocking CD226 can suppress this function.</description><subject>Antigens, Differentiation, T-Lymphocyte - metabolism</subject><subject>CD226</subject><subject>CD4+ T cells</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>Cytokines - metabolism</subject><subject>endometriosis</subject><subject>Endometriosis - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-10 - metabolism</subject><subject>Receptors, Immunologic</subject><subject>TIGIT</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1881-7815</issn><issn>1881-7823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kElPwzAQRi0EolXplSPKEQmleIkT54haNlGJS--W40ypq2x4XAH_nqSF-DC2Zt58sh4h14wupFT8vsCw4JTzBWWSsjMyZUqxOFNcnI9vJidkjrin_ZEpU1l6SSYio4qlqZqStxVYDwYhck20XHGeRvDdeUB0bRO1Qy-5izaRharCgelMcNAEjL5c2EXQlG0NwbsWHV6Ri62pEOZ_94xsnh43y5d4_f78unxYxzZRaYhzYxIoGbMqLY1KkrwsjZCF4AlwalWZ9JOMipLJ3OSZoFZISRUtIE2klFzMyO0ptvPt5wEw6Nrh8D_TQHtAzRWVVIhcZT26OKHWt4getrrzrjb-RzOqB4W6V6gHhfqosF-4-cs-FDWUI_4vrAdWJ2CPwXzACBgfnK3gmMcyzY9lzB3Hdme8hkb8Aj_pgco</recordid><startdate>20230430</startdate><enddate>20230430</enddate><creator>Li, Cui</creator><creator>Zhou, Jing</creator><creator>Shao, Jun</creator><creator>Yuan, Lei</creator><creator>Cheng, Qiang</creator><creator>Wang, Ling</creator><creator>Duan, Zhongliang</creator><general>International Research and Cooperation Association for Bio & Socio-Sciences Advancement</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230430</creationdate><title>Decrease in CD226 expression on CD4+ T cells in patients with endometriosis</title><author>Li, Cui ; Zhou, Jing ; Shao, Jun ; Yuan, Lei ; Cheng, Qiang ; Wang, Ling ; Duan, Zhongliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-9aa4ed11c86da8449dda35b324e20c8d41c8703d159a9730c355080be6455523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antigens, Differentiation, T-Lymphocyte - metabolism</topic><topic>CD226</topic><topic>CD4+ T cells</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>Cytokines - metabolism</topic><topic>endometriosis</topic><topic>Endometriosis - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-10 - metabolism</topic><topic>Receptors, Immunologic</topic><topic>TIGIT</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Cui</creatorcontrib><creatorcontrib>Zhou, Jing</creatorcontrib><creatorcontrib>Shao, Jun</creatorcontrib><creatorcontrib>Yuan, Lei</creatorcontrib><creatorcontrib>Cheng, Qiang</creatorcontrib><creatorcontrib>Wang, Ling</creatorcontrib><creatorcontrib>Duan, Zhongliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BioScience Trends</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Cui</au><au>Zhou, Jing</au><au>Shao, Jun</au><au>Yuan, Lei</au><au>Cheng, Qiang</au><au>Wang, Ling</au><au>Duan, Zhongliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease in CD226 expression on CD4+ T cells in patients with endometriosis</atitle><jtitle>BioScience Trends</jtitle><addtitle>BST</addtitle><date>2023-04-30</date><risdate>2023</risdate><volume>17</volume><issue>2</issue><spage>168</spage><epage>171</epage><pages>168-171</pages><artnum>2022.01501</artnum><issn>1881-7815</issn><eissn>1881-7823</eissn><abstract>Endometriosis is a chronic inflammatory disease. The immune-checkpoint molecules CD226 and TIGIT play an important role in regulating T cells' function. However, little is known about the proportion and function of CD226 and TIGIT on CD4+ T cells in endometriosis. The current study found no significant differences in the TIGIT percentage on peripheral CD4+ T cells between patients with endometriosis and the control group. However, CD226 was lower in patients with endometriosis than that in the control group (P < 0.01). The cytokines TNF-α, IL10, and IFN-γ were significantly elevated in TIGIT+ CD4+ T cells compared to TIGIT- CD4+ T cells. HLA-DR+ cells were more numerous among TIGIT+ CD4+ T cells than among the TIGIT- subset (P <0.001). Similarly, the cytokines TNF-α, IL10, and IFN-γ were significantly elevated in CD226+ CD4+ T cells compared to levels in CD226- CD4+ T cells. The proportion of HLA-DR+ CD4+ T cells among CD226+ CD4+ T cells was also significantly higher than that among the CD226- subset (P < 0.001). After TIGIT was blocked, the level of IL-10 in TIGIT+ CD4+ T cells was higher than that in cells with unblocked TIGIT. There were no differences in TNF-α and IFN-γ. After CD226 was blocked, TNF-α and IFN-γwere lower while IL-10 was higher. In conclusion, there is a diminution of CD226 in CD4+ T cells in patients with endometriosis. This is correlated with the effector function of CD4+ T cells, and blocking CD226 can suppress this function.</abstract><cop>Japan</cop><pub>International Research and Cooperation Association for Bio & Socio-Sciences Advancement</pub><pmid>37081668</pmid><doi>10.5582/bst.2022.01501</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens, Differentiation, T-Lymphocyte - metabolism CD226 CD4+ T cells CD4-Positive T-Lymphocytes - metabolism Cytokines - metabolism endometriosis Endometriosis - metabolism Female Humans Interleukin-10 - metabolism Receptors, Immunologic TIGIT Tumor Necrosis Factor-alpha - metabolism |
| title | Decrease in CD226 expression on CD4+ T cells in patients with endometriosis |
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