Asymmetric Assembly and Self-Adjuvanted Antigen Delivery Platform for Improved Antigen Uptake and Antitumor Effect

The development of effective tumor vaccines is an important direction in the field of cancer prevention/immunotherapy. Efficient antigen delivery is essential for inducing effective antitumor responses for tumor vaccines. Lumazine synthase (BLS) from Brucella spp. is a decameric protein with deliver...

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Veröffentlicht in:	Bioconjugate chemistry 2023-05, Vol.34 (5), p.856-865
Hauptverfasser:	Yang, Jianghua, Zhang, Jinsong, Yan, Ping, Zhang, Zhao, Gao, Weiyu, Xu, Man, Xu, Xinling, Liu, Baoshan, Chen, Zeliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - metabolism Animals Anticancer properties Antigen presentation Antigens Antitumor activity Assembly Asymmetry Autoantigens Autoantigens - metabolism Cancer vaccines Cancer Vaccines - therapeutic use CD8 antigen CD8-Positive T-Lymphocytes Cell-Penetrating Peptides - chemistry Dendritic Cells Display devices Histocompatibility Antigens Class I - metabolism Immunotherapy Internalization Lumazine synthase Lymphocytes Lymphocytes T Major histocompatibility complex Mice Mice, Inbred C57BL Neoplasms - metabolism Ovalbumin Peptides Plugs Proteins Tumors Vaccines
Online-Zugang:	Volltext
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