Mast cell migration and organization in tissues depend on integrin–ECM interactions

Mast cell migration and organization in tissues depend on integrin–ECM interactions

Many immune cell subsets move in an amoeboid fashion and do not require strong adhesive interactions with their surrounding when moving through interstitial tissue spaces. In stark contrast, we show that mast cells critically depend on integrin-mediated adhesion and interactions with the extracellul...

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Veröffentlicht in:Nature immunology 2023-06, Vol.24 (6), p.899-900
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631/80/84
Adhesives
Biomedical and Life Sciences
Biomedicine
Cell Adhesion
Cell adhesion & migration
Cell migration
Cell Movement
Extracellular Matrix
Immunology
Infectious Diseases
Integrins
Leukocytes
Ligands
Mast Cells
Morphology
Physiology
Research Briefing
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description Many immune cell subsets move in an amoeboid fashion and do not require strong adhesive interactions with their surrounding when moving through interstitial tissue spaces. In stark contrast, we show that mast cells critically depend on integrin-mediated adhesion and interactions with the extracellular matrix to enable slow migration and site-specific positioning in tissues.
doi_str_mv 10.1038/s41590-023-01494-1
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subjects 631/250/2503
631/80/84
Adhesives
Biomedical and Life Sciences
Biomedicine
Cell Adhesion
Cell adhesion & migration
Cell migration
Cell Movement
Extracellular Matrix
Immunology
Infectious Diseases
Integrins
Leukocytes
Ligands
Mast Cells
Morphology
Physiology
Research Briefing
title Mast cell migration and organization in tissues depend on integrin–ECM interactions
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