Mast cell migration and organization in tissues depend on integrin–ECM interactions

Mast cell migration and organization in tissues depend on integrin–ECM interactions

Many immune cell subsets move in an amoeboid fashion and do not require strong adhesive interactions with their surrounding when moving through interstitial tissue spaces. In stark contrast, we show that mast cells critically depend on integrin-mediated adhesion and interactions with the extracellul...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature immunology 2023-06, Vol.24 (6), p.899-900
Format: Artikel
Sprache:eng
Schlagworte:
631/250/2503
631/80/84
Adhesives
Biomedical and Life Sciences
Biomedicine
Cell Adhesion
Cell adhesion & migration
Cell migration
Cell Movement
Extracellular Matrix
Immunology
Infectious Diseases
Integrins
Leukocytes
Ligands
Mast Cells
Morphology
Physiology
Research Briefing
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Many immune cell subsets move in an amoeboid fashion and do not require strong adhesive interactions with their surrounding when moving through interstitial tissue spaces. In stark contrast, we show that mast cells critically depend on integrin-mediated adhesion and interactions with the extracellular matrix to enable slow migration and site-specific positioning in tissues.
ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-023-01494-1