A novel method for predicting the unbound valproic acid concentration

A novel method for predicting the unbound valproic acid concentration

In this study, we constructed a prediction formula for unbound valproic acid (VPA) concentration that was more accurate and widely applicable than previously reported formulae. A total of 136 datasets from 75 patients were analyzed retrospectively. The median of free fraction of VPA was 0.16 (interq...

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Veröffentlicht in:Drug metabolism and pharmacokinetics 2023-06, Vol.50, p.100503-100503, Article 100503
Hauptverfasser: Ishikawa, Masayuki, Uchida, Masashi, Asakawa, Takahiro, Suzuki, Shota, Yamazaki, Shingo, Shiko, Yuki, Kawasaki, Yohei, Suzuki, Takaaki, Ishii, Itsuko
Format: Artikel
Sprache:eng
Schlagworte:
Anticonvulsants - therapeutic use
Bipolar disorder
Epilepsy
Epilepsy - drug therapy
Humans
Protein binding
Renal Insufficiency
Retrospective Studies
Therapeutic drug monitoring
Valproic acid
Valproic Acid - therapeutic use
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Zusammenfassung:In this study, we constructed a prediction formula for unbound valproic acid (VPA) concentration that was more accurate and widely applicable than previously reported formulae. A total of 136 datasets from 75 patients were analyzed retrospectively. The median of free fraction of VPA was 0.16 (interquartile range: 0.07; range: 0.07–0.45). The parameter that combined total VPA concentration (CtVPA) and serum albumin (SA), (CtVPA [μM] – 2 × SA [μM]), was significantly related to the free fraction of VPA (r = 0.76, p 
ISSN:1347-4367
1880-0920
DOI:10.1016/j.dmpk.2023.100503