Competent antioxidant and antiglycation properties of zinc oxide nanoparticles (ZnO-NPs) phyto-fabricated from aqueous leaf extract of Boerhaavia erecta L
During the present century, plant-based zinc oxide nanoparticles (ZnO-NPs) are exploited extensively for their vast biological properties due to their unique characteristic features and eco-friendly nature. Diabetes is one of the fast-growing human diseases/abnormalities worldwide, and the need for...
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| Veröffentlicht in: | Environmental science and pollution research international 2023-04, Vol.30 (19), p.56731-56742 |
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| creator | Murali, Mahadevamurthy Thampy, Anjana Anandan, Satish Aiyaz, Mohammed Shilpa, Natarajamurthy Singh, Sudarshana Brijesh Gowtham, Hittanahallikoppal Gajendramurthy Ramesh, Abhilash Mavinakere Rahdar, Abbas Kyzas, George Z. |
| description | During the present century, plant-based zinc oxide nanoparticles (ZnO-NPs) are exploited extensively for their vast biological properties due to their unique characteristic features and eco-friendly nature. Diabetes is one of the fast-growing human diseases/abnormalities worldwide, and the need for new/ novel antiglycation products is the need of the hour. The study deals with the phyto-fabrication of ZnO-NPs from
Boerhaavia erecta
, a medicinally important plant, and to evaluate their antioxidant and antiglycation ability in vitro. UV-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) were used to characterize the phyto-fabricated ZnO-NPs. The characterization of nanoparticles revealed that the particles showed an absorption peak at 362 nm and band gap energy of 3.2 eV, approximately 20.55 nm in size, with a ZnO elemental purity of 96.61%. The synthesized particles were found agglomerated when observed under SEM, and the FT-IR studies proved that the phyto-constituents of the extract involved during the different stages (reduction, capping, and stabilization) of nanoparticles synthesis. The antioxidant and metal chelating activities confirmed that ZnO-NPs could inhibit the free radicals generated, which was dose-dependent with an IC
50
value between 1.81 and 1.94 mg mL
–1
, respectively. In addition, the phyto-fabricated nanoparticles blocked the formation of advanced glycation end products (AGEs) as noticed through inhibition of Amadori products, trapping of reactive dicarbonyl intermediate and breaking the cross-link of glycated protein. It was also noted that the phyto-fabricated ZnO-NPs significantly prevented the damage of red blood corpuscles (RBCs) induced by MGO. The present study’s findings will provide an experimental basis for exploring ZnO-NPs in diabetes-related complications. |
| doi_str_mv | 10.1007/s11356-023-26331-8 |
| format | Article |
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Boerhaavia erecta
, a medicinally important plant, and to evaluate their antioxidant and antiglycation ability in vitro. UV-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) were used to characterize the phyto-fabricated ZnO-NPs. The characterization of nanoparticles revealed that the particles showed an absorption peak at 362 nm and band gap energy of 3.2 eV, approximately 20.55 nm in size, with a ZnO elemental purity of 96.61%. The synthesized particles were found agglomerated when observed under SEM, and the FT-IR studies proved that the phyto-constituents of the extract involved during the different stages (reduction, capping, and stabilization) of nanoparticles synthesis. The antioxidant and metal chelating activities confirmed that ZnO-NPs could inhibit the free radicals generated, which was dose-dependent with an IC
50
value between 1.81 and 1.94 mg mL
–1
, respectively. In addition, the phyto-fabricated nanoparticles blocked the formation of advanced glycation end products (AGEs) as noticed through inhibition of Amadori products, trapping of reactive dicarbonyl intermediate and breaking the cross-link of glycated protein. It was also noted that the phyto-fabricated ZnO-NPs significantly prevented the damage of red blood corpuscles (RBCs) induced by MGO. The present study’s findings will provide an experimental basis for exploring ZnO-NPs in diabetes-related complications.</description><identifier>ISSN: 1614-7499</identifier><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-023-26331-8</identifier><identifier>PMID: 36929264</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abnormalities ; absorption ; Advanced glycosylation end products ; Amadori compounds ; Anti-Bacterial Agents - chemistry ; Antioxidants ; Antioxidants - pharmacology ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Biological properties ; blood ; Chelation ; Corpuscles ; Damage prevention ; Diabetes ; Diabetes mellitus ; dose response ; Earth and Environmental Science ; Ecotoxicology ; electron microscopy ; energy ; Energy gap ; energy-dispersive X-ray analysis ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Fabrication ; Fourier transform infrared spectroscopy ; Fourier transforms ; Free radicals ; Glycosylation ; Humans ; Infrared spectroscopy ; leaf extracts ; Medicinal plants ; Metal Nanoparticles - chemistry ; Nanoparticles ; Nanoparticles - chemistry ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Research Article ; Scanning electron microscopy ; Spectroscopy, Fourier Transform Infrared ; Spectrum analysis ; ultraviolet-visible spectroscopy ; Waste Water Technology ; Water Management ; Water Pollution Control ; X-Ray Diffraction ; Zinc oxide ; Zinc Oxide - chemistry ; Zinc oxides</subject><ispartof>Environmental science and pollution research international, 2023-04, Vol.30 (19), p.56731-56742</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-9377585f8dc3ae7ec1e927db64d1d107a13162d65eea8d37b92678b3150d5de73</citedby><cites>FETCH-LOGICAL-c408t-9377585f8dc3ae7ec1e927db64d1d107a13162d65eea8d37b92678b3150d5de73</cites><orcidid>0000-0003-1516-3761</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-023-26331-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-023-26331-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36929264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murali, Mahadevamurthy</creatorcontrib><creatorcontrib>Thampy, Anjana</creatorcontrib><creatorcontrib>Anandan, Satish</creatorcontrib><creatorcontrib>Aiyaz, Mohammed</creatorcontrib><creatorcontrib>Shilpa, Natarajamurthy</creatorcontrib><creatorcontrib>Singh, Sudarshana Brijesh</creatorcontrib><creatorcontrib>Gowtham, Hittanahallikoppal Gajendramurthy</creatorcontrib><creatorcontrib>Ramesh, Abhilash Mavinakere</creatorcontrib><creatorcontrib>Rahdar, Abbas</creatorcontrib><creatorcontrib>Kyzas, George Z.</creatorcontrib><title>Competent antioxidant and antiglycation properties of zinc oxide nanoparticles (ZnO-NPs) phyto-fabricated from aqueous leaf extract of Boerhaavia erecta L</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>During the present century, plant-based zinc oxide nanoparticles (ZnO-NPs) are exploited extensively for their vast biological properties due to their unique characteristic features and eco-friendly nature. Diabetes is one of the fast-growing human diseases/abnormalities worldwide, and the need for new/ novel antiglycation products is the need of the hour. The study deals with the phyto-fabrication of ZnO-NPs from
Boerhaavia erecta
, a medicinally important plant, and to evaluate their antioxidant and antiglycation ability in vitro. UV-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) were used to characterize the phyto-fabricated ZnO-NPs. The characterization of nanoparticles revealed that the particles showed an absorption peak at 362 nm and band gap energy of 3.2 eV, approximately 20.55 nm in size, with a ZnO elemental purity of 96.61%. The synthesized particles were found agglomerated when observed under SEM, and the FT-IR studies proved that the phyto-constituents of the extract involved during the different stages (reduction, capping, and stabilization) of nanoparticles synthesis. The antioxidant and metal chelating activities confirmed that ZnO-NPs could inhibit the free radicals generated, which was dose-dependent with an IC
50
value between 1.81 and 1.94 mg mL
–1
, respectively. In addition, the phyto-fabricated nanoparticles blocked the formation of advanced glycation end products (AGEs) as noticed through inhibition of Amadori products, trapping of reactive dicarbonyl intermediate and breaking the cross-link of glycated protein. It was also noted that the phyto-fabricated ZnO-NPs significantly prevented the damage of red blood corpuscles (RBCs) induced by MGO. The present study’s findings will provide an experimental basis for exploring ZnO-NPs in diabetes-related complications.</description><subject>Abnormalities</subject><subject>absorption</subject><subject>Advanced glycosylation end products</subject><subject>Amadori compounds</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Biological properties</subject><subject>blood</subject><subject>Chelation</subject><subject>Corpuscles</subject><subject>Damage prevention</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>dose response</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>electron microscopy</subject><subject>energy</subject><subject>Energy gap</subject><subject>energy-dispersive X-ray analysis</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Fabrication</subject><subject>Fourier transform infrared spectroscopy</subject><subject>Fourier transforms</subject><subject>Free radicals</subject><subject>Glycosylation</subject><subject>Humans</subject><subject>Infrared spectroscopy</subject><subject>leaf extracts</subject><subject>Medicinal plants</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Research Article</subject><subject>Scanning electron microscopy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Spectrum analysis</subject><subject>ultraviolet-visible spectroscopy</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>X-Ray Diffraction</subject><subject>Zinc oxide</subject><subject>Zinc Oxide - chemistry</subject><subject>Zinc oxides</subject><issn>1614-7499</issn><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1u1DAUhS0EomXgBVggS2zKIq1_kthZ0hF_0oiygA2b6Ma-aVMldrA9qMOj8LQ4M6UgFmXla9_Px_f4EPKcs1POmDqLnMuqLpiQhail5IV-QI55zctClU3z8K_6iDyJ8ZoxwRqhHpMjWTeiEXV5TH6u_TRjQpcouDT4m8HCvrb7_eW4M5CPHZ2DnzGkASP1Pf0xOEMXGKkD52fIHTPm3slXd1F8_BRf0flql3zRQxeGLIGW9sFPFL5t0W8jHRF6ijcpgEmL4LnHcAXwfQCKAU0CunlKHvUwRnx2u67Il7dvPq_fF5uLdx_WrzeFKZlORSOVqnTVa2skoELDMZu0XV1abjlTwCWvha0rRNBWqi4bV7qTvGK2sqjkipwcdLPFPF1M7TREg-MIbhm1zaTkqsp_9l9UaFYxUVc5jRV5-Q967bfBZSMLpRrNdKkzJQ6UCT7GgH07h2GCsGs5a5eQ20PIbQ653YfcLpde3Epvuwnt3ZXfqWZAHoCYW-4Sw5-375H9BUjQs7c</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Murali, Mahadevamurthy</creator><creator>Thampy, Anjana</creator><creator>Anandan, Satish</creator><creator>Aiyaz, Mohammed</creator><creator>Shilpa, Natarajamurthy</creator><creator>Singh, Sudarshana Brijesh</creator><creator>Gowtham, Hittanahallikoppal Gajendramurthy</creator><creator>Ramesh, Abhilash Mavinakere</creator><creator>Rahdar, Abbas</creator><creator>Kyzas, George Z.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-1516-3761</orcidid></search><sort><creationdate>20230401</creationdate><title>Competent antioxidant and antiglycation properties of zinc oxide nanoparticles (ZnO-NPs) phyto-fabricated from aqueous leaf extract of Boerhaavia erecta L</title><author>Murali, Mahadevamurthy ; Thampy, Anjana ; Anandan, Satish ; Aiyaz, Mohammed ; Shilpa, Natarajamurthy ; Singh, Sudarshana Brijesh ; Gowtham, Hittanahallikoppal Gajendramurthy ; Ramesh, Abhilash Mavinakere ; Rahdar, Abbas ; Kyzas, George Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-9377585f8dc3ae7ec1e927db64d1d107a13162d65eea8d37b92678b3150d5de73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abnormalities</topic><topic>absorption</topic><topic>Advanced glycosylation end products</topic><topic>Amadori compounds</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Biological properties</topic><topic>blood</topic><topic>Chelation</topic><topic>Corpuscles</topic><topic>Damage prevention</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>dose response</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>electron microscopy</topic><topic>energy</topic><topic>Energy gap</topic><topic>energy-dispersive X-ray analysis</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Fabrication</topic><topic>Fourier transform infrared spectroscopy</topic><topic>Fourier transforms</topic><topic>Free radicals</topic><topic>Glycosylation</topic><topic>Humans</topic><topic>Infrared spectroscopy</topic><topic>leaf extracts</topic><topic>Medicinal plants</topic><topic>Metal Nanoparticles - 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Diabetes is one of the fast-growing human diseases/abnormalities worldwide, and the need for new/ novel antiglycation products is the need of the hour. The study deals with the phyto-fabrication of ZnO-NPs from
Boerhaavia erecta
, a medicinally important plant, and to evaluate their antioxidant and antiglycation ability in vitro. UV-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) were used to characterize the phyto-fabricated ZnO-NPs. The characterization of nanoparticles revealed that the particles showed an absorption peak at 362 nm and band gap energy of 3.2 eV, approximately 20.55 nm in size, with a ZnO elemental purity of 96.61%. The synthesized particles were found agglomerated when observed under SEM, and the FT-IR studies proved that the phyto-constituents of the extract involved during the different stages (reduction, capping, and stabilization) of nanoparticles synthesis. The antioxidant and metal chelating activities confirmed that ZnO-NPs could inhibit the free radicals generated, which was dose-dependent with an IC
50
value between 1.81 and 1.94 mg mL
–1
, respectively. In addition, the phyto-fabricated nanoparticles blocked the formation of advanced glycation end products (AGEs) as noticed through inhibition of Amadori products, trapping of reactive dicarbonyl intermediate and breaking the cross-link of glycated protein. It was also noted that the phyto-fabricated ZnO-NPs significantly prevented the damage of red blood corpuscles (RBCs) induced by MGO. The present study’s findings will provide an experimental basis for exploring ZnO-NPs in diabetes-related complications.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36929264</pmid><doi>10.1007/s11356-023-26331-8</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1516-3761</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1614-7499 |
| ispartof | Environmental science and pollution research international, 2023-04, Vol.30 (19), p.56731-56742 |
| issn | 1614-7499 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2805026563 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Abnormalities absorption Advanced glycosylation end products Amadori compounds Anti-Bacterial Agents - chemistry Antioxidants Antioxidants - pharmacology Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Biological properties blood Chelation Corpuscles Damage prevention Diabetes Diabetes mellitus dose response Earth and Environmental Science Ecotoxicology electron microscopy energy Energy gap energy-dispersive X-ray analysis Environment Environmental Chemistry Environmental Health Environmental science Fabrication Fourier transform infrared spectroscopy Fourier transforms Free radicals Glycosylation Humans Infrared spectroscopy leaf extracts Medicinal plants Metal Nanoparticles - chemistry Nanoparticles Nanoparticles - chemistry Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Research Article Scanning electron microscopy Spectroscopy, Fourier Transform Infrared Spectrum analysis ultraviolet-visible spectroscopy Waste Water Technology Water Management Water Pollution Control X-Ray Diffraction Zinc oxide Zinc Oxide - chemistry Zinc oxides |
| title | Competent antioxidant and antiglycation properties of zinc oxide nanoparticles (ZnO-NPs) phyto-fabricated from aqueous leaf extract of Boerhaavia erecta L |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T12%3A55%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Competent%20antioxidant%20and%20antiglycation%20properties%20of%20zinc%20oxide%20nanoparticles%20(ZnO-NPs)%20phyto-fabricated%20from%20aqueous%20leaf%20extract%20of%20Boerhaavia%20erecta%20L&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Murali,%20Mahadevamurthy&rft.date=2023-04-01&rft.volume=30&rft.issue=19&rft.spage=56731&rft.epage=56742&rft.pages=56731-56742&rft.issn=1614-7499&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-023-26331-8&rft_dat=%3Cproquest_cross%3E2807980848%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2807980848&rft_id=info:pmid/36929264&rfr_iscdi=true |