Amitriptyline efficacy in decreasing implant‐induced foreign body reaction

Beyond its actions on the nervous system, amitriptyline (AM) has been shown to lower inflammatory, angiogenic, and fibrogenic markers in a few pathological conditions in human and in experimental animal models. However, its effects on foreign body reaction (FBR), a complex adverse healing process, a...

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Veröffentlicht in:	IUBMB life 2023-09, Vol.75 (9), p.732-742
Hauptverfasser:	Scheuermann, Karina, Viana, Celso Tarso Rodrigues, Reis, Diego Carlos, Lazari, Marcela Guimarães Takahashi, Orellano, Laura Alejandra Ariza, Machado, Clara Tolentino, Santos, Leticia Cristine Cardoso, Ulrich, Henning, Capettini, Luciano Santos Aggum, Andrade, Silvia Passos, Campos, Paula Peixoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitriptyline Angiogenesis Animal models Foreign bodies foreign body reaction Inflammation matrix remodeling Nervous system Oral administration sponge model Transplants & implants Vascular endothelial growth factor
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