IL-37 alleviates TNF-α-induced pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes by inhibiting the NF-κB/GSDMD signaling pathway

•RA-FLSs can secrete many pro-inflammatory factors, inhibiting apoptosis.•NF-κB acts as an upstream signaling pathway to regulate pyroptosis.•Arthritic symptoms were significantly alleviated by IL-37.•IL-37 has a favorable therapeutic effect on CIA rats in vivo. Pyroptosis is crucial to rheumatoid a...

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Veröffentlicht in:	Immunobiology (1979) 2023-05, Vol.228 (3), p.152382-152382, Article 152382
Hauptverfasser:	Ren, Chunfeng, Chen, Jie, Che, Qincheng, Jia, Qian, Lu, Hongqin, Qi, Xiaoyan, Zhang, Xiaojie, Shu, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Fibroblast-like synoviocytes IL-37 NF-κB Pyroptosis Rheumatoid arthritis TNF-α
Online-Zugang:	Volltext
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