Associations between adiponectin and leptin levels and skeletal muscle mass and myosteatosis in older adults: The Shimanami Health Promoting Program study
Aim Identifying plasma molecules associated with skeletal muscle properties can elucidate the pathophysiology of sarcopenia. Because adipocytokines are a promising candidate marker, the current study aimed to clarify the possible associations between adiponectin and leptin levels and mid‐thigh muscl...
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| Veröffentlicht in: | Geriatrics & gerontology international 2023-06, Vol.23 (6), p.444-449 |
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| creator | Tabara, Yasuharu Okada, Yoko Ochi, Masayuki Ohyagi, Yasumasa Igase, Michiya |
| description | Aim
Identifying plasma molecules associated with skeletal muscle properties can elucidate the pathophysiology of sarcopenia. Because adipocytokines are a promising candidate marker, the current study aimed to clarify the possible associations between adiponectin and leptin levels and mid‐thigh muscle cross‐sectional area and mean attenuation value, which are indices of muscle mass and fat deposition in muscle, respectively.
Methods
The current study included 1440 older Japanese adults (mean age 69.3 years). Mid‐thigh skeletal muscle cross‐sectional area and mean attenuation value were evaluated through computed tomography scan. A low attenuation value showed a greater fat deposition in muscle. Circulating adiponectin and leptin levels were assessed using blood specimens collected during the baseline investigation.
Results
Plasma leptin level was inversely correlated with muscle cross‐sectional area, but not with attenuation value. The association with cross‐sectional area was independent of possible confounding factors including body size (Q1: reference; Q2: β = −0.032, P = 0.033; Q3: β = −0.064, P |
| doi_str_mv | 10.1111/ggi.14582 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2803966073</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2803966073</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3772-217ba7a44c955ff67ac3c54d90efddb3889ae2ff28c0e9291783fb6058aecfce3</originalsourceid><addsrcrecordid>eNp1kcFu1DAURS0EoqWw4AeQJTawSGvHTuywq6oyrVSplSjryHGeZ1yceMhzqOZX-rV4JoUFEt74yj4-etYl5D1npzyvs_Xan3JZ6fIFOeZSqoJVjXx5yLLgla6PyBvEB8a4ajh_TY6EYkpz0RyTp3PEaL1JPo5IO0iPACM1vd_GEWzyOY89DbDdxwC_IODhBH9AgGQCHWa0AehgcLkYdhETmBTRI81vYuhhysI5JPxC7zdAv238YEYzeHoFJqQNvZviELN_vU_ryQwU09zv3pJXzgSEd8_7Cfn-9fL-4qq4uV1dX5zfFFYoVRYlV51RRkrbVJVztTJW2Er2DQPX953QujFQOldqy6ApG660cF3NKm3AOgvihHxavNsp_pwBUzt4tBCCGSHO2JaaiaaumRIZ_fgP-hDnaczTZarkUkkudaY-L5SdIuIErt1O-cvTruWs3RfW5sLaQ2GZ_fBsnLsB-r_kn4YycLYAjz7A7v-mdrW6XpS_AYzgoso</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2821474148</pqid></control><display><type>article</type><title>Associations between adiponectin and leptin levels and skeletal muscle mass and myosteatosis in older adults: The Shimanami Health Promoting Program study</title><source>Access via Wiley Online Library</source><creator>Tabara, Yasuharu ; Okada, Yoko ; Ochi, Masayuki ; Ohyagi, Yasumasa ; Igase, Michiya</creator><creatorcontrib>Tabara, Yasuharu ; Okada, Yoko ; Ochi, Masayuki ; Ohyagi, Yasumasa ; Igase, Michiya</creatorcontrib><description>Aim
Identifying plasma molecules associated with skeletal muscle properties can elucidate the pathophysiology of sarcopenia. Because adipocytokines are a promising candidate marker, the current study aimed to clarify the possible associations between adiponectin and leptin levels and mid‐thigh muscle cross‐sectional area and mean attenuation value, which are indices of muscle mass and fat deposition in muscle, respectively.
Methods
The current study included 1440 older Japanese adults (mean age 69.3 years). Mid‐thigh skeletal muscle cross‐sectional area and mean attenuation value were evaluated through computed tomography scan. A low attenuation value showed a greater fat deposition in muscle. Circulating adiponectin and leptin levels were assessed using blood specimens collected during the baseline investigation.
Results
Plasma leptin level was inversely correlated with muscle cross‐sectional area, but not with attenuation value. The association with cross‐sectional area was independent of possible confounding factors including body size (Q1: reference; Q2: β = −0.032, P = 0.033; Q3: β = −0.064, P < 0.001; Q4: β = −0.111, P < 0.001). In contrast, adiponectin level was independently and inversely associated with attenuation value (Q1: reference; Q2: β = −0.044, P = 0.122; Q3: β = −0.080, P = 0.006; Q4: β = −0.159, P < 0.001), but not with cross‐sectional area. These associations between adipocytokine levels and muscle properties were independent of abdominal fat area and insulin resistance.
Conclusions
There were adiposity‐ and insulin resistance‐independent associations between adipocytokines levels and skeletal muscle mass and fat deposition in muscle, suggesting an involvement of adipocytokines in muscle properties. Geriatr Gerontol Int 2023; 23: 444–449.
Adipocytokines levels were associated with skeletal muscle mass and fat deposition in muscle independent of adiposity and insulin resistance.
This suggests a possible relationship between adipocytokines and sarcopenia.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.14582</identifier><identifier>PMID: 37078139</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>adiponectin ; Insulin resistance ; leptin ; Musculoskeletal system ; myosteatosis ; Sarcopenia ; skeletal muscle mass</subject><ispartof>Geriatrics & gerontology international, 2023-06, Vol.23 (6), p.444-449</ispartof><rights>2023 Japan Geriatrics Society.</rights><rights>2023 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3772-217ba7a44c955ff67ac3c54d90efddb3889ae2ff28c0e9291783fb6058aecfce3</citedby><cites>FETCH-LOGICAL-c3772-217ba7a44c955ff67ac3c54d90efddb3889ae2ff28c0e9291783fb6058aecfce3</cites><orcidid>0000-0003-4505-7951</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fggi.14582$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fggi.14582$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37078139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabara, Yasuharu</creatorcontrib><creatorcontrib>Okada, Yoko</creatorcontrib><creatorcontrib>Ochi, Masayuki</creatorcontrib><creatorcontrib>Ohyagi, Yasumasa</creatorcontrib><creatorcontrib>Igase, Michiya</creatorcontrib><title>Associations between adiponectin and leptin levels and skeletal muscle mass and myosteatosis in older adults: The Shimanami Health Promoting Program study</title><title>Geriatrics & gerontology international</title><addtitle>Geriatr Gerontol Int</addtitle><description>Aim
Identifying plasma molecules associated with skeletal muscle properties can elucidate the pathophysiology of sarcopenia. Because adipocytokines are a promising candidate marker, the current study aimed to clarify the possible associations between adiponectin and leptin levels and mid‐thigh muscle cross‐sectional area and mean attenuation value, which are indices of muscle mass and fat deposition in muscle, respectively.
Methods
The current study included 1440 older Japanese adults (mean age 69.3 years). Mid‐thigh skeletal muscle cross‐sectional area and mean attenuation value were evaluated through computed tomography scan. A low attenuation value showed a greater fat deposition in muscle. Circulating adiponectin and leptin levels were assessed using blood specimens collected during the baseline investigation.
Results
Plasma leptin level was inversely correlated with muscle cross‐sectional area, but not with attenuation value. The association with cross‐sectional area was independent of possible confounding factors including body size (Q1: reference; Q2: β = −0.032, P = 0.033; Q3: β = −0.064, P < 0.001; Q4: β = −0.111, P < 0.001). In contrast, adiponectin level was independently and inversely associated with attenuation value (Q1: reference; Q2: β = −0.044, P = 0.122; Q3: β = −0.080, P = 0.006; Q4: β = −0.159, P < 0.001), but not with cross‐sectional area. These associations between adipocytokine levels and muscle properties were independent of abdominal fat area and insulin resistance.
Conclusions
There were adiposity‐ and insulin resistance‐independent associations between adipocytokines levels and skeletal muscle mass and fat deposition in muscle, suggesting an involvement of adipocytokines in muscle properties. Geriatr Gerontol Int 2023; 23: 444–449.
Adipocytokines levels were associated with skeletal muscle mass and fat deposition in muscle independent of adiposity and insulin resistance.
This suggests a possible relationship between adipocytokines and sarcopenia.</description><subject>adiponectin</subject><subject>Insulin resistance</subject><subject>leptin</subject><subject>Musculoskeletal system</subject><subject>myosteatosis</subject><subject>Sarcopenia</subject><subject>skeletal muscle mass</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kcFu1DAURS0EoqWw4AeQJTawSGvHTuywq6oyrVSplSjryHGeZ1yceMhzqOZX-rV4JoUFEt74yj4-etYl5D1npzyvs_Xan3JZ6fIFOeZSqoJVjXx5yLLgla6PyBvEB8a4ajh_TY6EYkpz0RyTp3PEaL1JPo5IO0iPACM1vd_GEWzyOY89DbDdxwC_IODhBH9AgGQCHWa0AehgcLkYdhETmBTRI81vYuhhysI5JPxC7zdAv238YEYzeHoFJqQNvZviELN_vU_ryQwU09zv3pJXzgSEd8_7Cfn-9fL-4qq4uV1dX5zfFFYoVRYlV51RRkrbVJVztTJW2Er2DQPX953QujFQOldqy6ApG660cF3NKm3AOgvihHxavNsp_pwBUzt4tBCCGSHO2JaaiaaumRIZ_fgP-hDnaczTZarkUkkudaY-L5SdIuIErt1O-cvTruWs3RfW5sLaQ2GZ_fBsnLsB-r_kn4YycLYAjz7A7v-mdrW6XpS_AYzgoso</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Tabara, Yasuharu</creator><creator>Okada, Yoko</creator><creator>Ochi, Masayuki</creator><creator>Ohyagi, Yasumasa</creator><creator>Igase, Michiya</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4505-7951</orcidid></search><sort><creationdate>202306</creationdate><title>Associations between adiponectin and leptin levels and skeletal muscle mass and myosteatosis in older adults: The Shimanami Health Promoting Program study</title><author>Tabara, Yasuharu ; Okada, Yoko ; Ochi, Masayuki ; Ohyagi, Yasumasa ; Igase, Michiya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3772-217ba7a44c955ff67ac3c54d90efddb3889ae2ff28c0e9291783fb6058aecfce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>adiponectin</topic><topic>Insulin resistance</topic><topic>leptin</topic><topic>Musculoskeletal system</topic><topic>myosteatosis</topic><topic>Sarcopenia</topic><topic>skeletal muscle mass</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabara, Yasuharu</creatorcontrib><creatorcontrib>Okada, Yoko</creatorcontrib><creatorcontrib>Ochi, Masayuki</creatorcontrib><creatorcontrib>Ohyagi, Yasumasa</creatorcontrib><creatorcontrib>Igase, Michiya</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabara, Yasuharu</au><au>Okada, Yoko</au><au>Ochi, Masayuki</au><au>Ohyagi, Yasumasa</au><au>Igase, Michiya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between adiponectin and leptin levels and skeletal muscle mass and myosteatosis in older adults: The Shimanami Health Promoting Program study</atitle><jtitle>Geriatrics & gerontology international</jtitle><addtitle>Geriatr Gerontol Int</addtitle><date>2023-06</date><risdate>2023</risdate><volume>23</volume><issue>6</issue><spage>444</spage><epage>449</epage><pages>444-449</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aim
Identifying plasma molecules associated with skeletal muscle properties can elucidate the pathophysiology of sarcopenia. Because adipocytokines are a promising candidate marker, the current study aimed to clarify the possible associations between adiponectin and leptin levels and mid‐thigh muscle cross‐sectional area and mean attenuation value, which are indices of muscle mass and fat deposition in muscle, respectively.
Methods
The current study included 1440 older Japanese adults (mean age 69.3 years). Mid‐thigh skeletal muscle cross‐sectional area and mean attenuation value were evaluated through computed tomography scan. A low attenuation value showed a greater fat deposition in muscle. Circulating adiponectin and leptin levels were assessed using blood specimens collected during the baseline investigation.
Results
Plasma leptin level was inversely correlated with muscle cross‐sectional area, but not with attenuation value. The association with cross‐sectional area was independent of possible confounding factors including body size (Q1: reference; Q2: β = −0.032, P = 0.033; Q3: β = −0.064, P < 0.001; Q4: β = −0.111, P < 0.001). In contrast, adiponectin level was independently and inversely associated with attenuation value (Q1: reference; Q2: β = −0.044, P = 0.122; Q3: β = −0.080, P = 0.006; Q4: β = −0.159, P < 0.001), but not with cross‐sectional area. These associations between adipocytokine levels and muscle properties were independent of abdominal fat area and insulin resistance.
Conclusions
There were adiposity‐ and insulin resistance‐independent associations between adipocytokines levels and skeletal muscle mass and fat deposition in muscle, suggesting an involvement of adipocytokines in muscle properties. Geriatr Gerontol Int 2023; 23: 444–449.
Adipocytokines levels were associated with skeletal muscle mass and fat deposition in muscle independent of adiposity and insulin resistance.
This suggests a possible relationship between adipocytokines and sarcopenia.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>37078139</pmid><doi>10.1111/ggi.14582</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4505-7951</orcidid></addata></record> |
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| subjects | adiponectin Insulin resistance leptin Musculoskeletal system myosteatosis Sarcopenia skeletal muscle mass |
| title | Associations between adiponectin and leptin levels and skeletal muscle mass and myosteatosis in older adults: The Shimanami Health Promoting Program study |
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