Reperfusion-induced injury and the effects of the dithioacetate type hydrogen sulfide donor ibuprofen derivative, BM-88, in isolated rat hearts

Hydrogen sulfide (H2S) plays an important role in cardiac protection by regulating various redox signalings associated with myocardial ischemia/reperfusion (I/R) induced injury. The goal of the present investigations is the synthesis of a newly designed H2S-releasing ibuprofen derivative, BM-88, and...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2023-06, Vol.185, p.106449-106449, Article 106449
Hauptverfasser:	Vass, Virág, Szabó, Erzsébet, Bereczki, Ilona, Debreczeni, Nóra, Borbás, Anikó, Herczegh, Pál, Tósaki, Árpád
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias Cell death H2S-donor Heart Hydrogen Sulfide - pharmacology Ibuprofen - pharmacology Ibuprofen - therapeutic use Ischemia/reperfusion Rats Reperfusion Reperfusion Injury
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