USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC‐3 and SW1990 cells

Ubiquitin‐specific protease 33 (USP33) has been implicated in various cancers, but its biological function and mechanism of action remain unknown in pancreatic cancer (PCa) as a deubiquitinating enzyme. Herein, we report that USP33 silencing inhibits PCa cell survival and self‐renewal. USPs highly e...

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Veröffentlicht in:	Cell biology international 2023-08, Vol.47 (8), p.1368-1380
Hauptverfasser:	Zhong, Bo, Zhu, Qiaozhen, Wang, Linpei, Wang, Fuyu, Zheng, Yongbin, Lin, Shujun, Cheng, Xinsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	CD44 antigen Cell growth Cell proliferation Cell self-renewal Cell survival Cholecystokinin Colonies CTNNB1 Myc protein Pancreatic cancer Proliferating cell nuclear antigen proliferation stemness Ubiquitin Ubiquitination USP33
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