Inheritance of directed DNA cytosine methylation in mammals

Inheritance of directed DNA cytosine methylation in mammals

A recent study performed directed C5-cytosine methylation of CpG islands to demonstrate that acquired methylation at critical loci could be reestablished for multiple generations in mice. This work provides a manipulatable system to examine how non-genetic information is transmitted across generatio...

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Veröffentlicht in:Lab animal 2023-05, Vol.52 (5), p.105-107
Hauptverfasser: Sarkar, Gautam, Greer, Eric Lieberman
Format: Artikel
Sprache:eng
Schlagworte:
631/136
631/208
631/208/176/1988
Animal Models
Animals
Biomedical and Life Sciences
CpG islands
CRISPR
Cytosine
Disease
DNA - metabolism
DNA Methylation
Epigenetics
Genes
Genotype & phenotype
Life Sciences
Mammals - genetics
Metabolism
News & Views
news-and-views
Obesity
Phenotypes
Stem cells
Veterinary Medicine/Veterinary Science
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Beschreibung
Zusammenfassung:A recent study performed directed C5-cytosine methylation of CpG islands to demonstrate that acquired methylation at critical loci could be reestablished for multiple generations in mice. This work provides a manipulatable system to examine how non-genetic information is transmitted across generations to regulate complex phenotypes.
ISSN:0093-7355
1548-4475
DOI:10.1038/s41684-023-01158-5