The combined effect of zinc oxide nanoparticles and milrinone on acute renal ischemia/reperfusion injury in rats: Potential underlying mechanisms

To investigate the efficacy of zinc oxide nanoparticles (ZnO-NPs) and/or milrinone (MIL) on renal ischemia/reperfusion injury (I/RI) in rats and their possible underlying mechanisms. Forty-eight adult male Sprague-Dawley albino rats were randomly assigned into six equal-sized groups (n = 8): normal...

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Veröffentlicht in:	Life sciences (1973) 2023-06, Vol.323, p.121435-121435, Article 121435
Hauptverfasser:	Embaby, Eman M., Saleh, Rasha M., Marghani, Basma H., Barakat, Nashwa, Awadin, Walaa, Elshal, Mohamed F., Ali, Islam S., Abu-Heakal, Nabil
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - prevention & control Acute renal ischemia/reperfusion injury Animals Apoptosis Caspase 3 - metabolism Inflammation Ischemia Lipocalin-2 - metabolism Male Milrinone Milrinone - pharmacology Milrinone - therapeutic use Nanoparticles NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Oxidative Stress Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Reperfusion Injury - pathology Reperfusion Injury - prevention & control Tumor Necrosis Factor-alpha - metabolism Zinc Oxide - pharmacology Zinc Oxide - therapeutic use Zinc oxide nanoparticles
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Zusammenfassung:	To investigate the efficacy of zinc oxide nanoparticles (ZnO-NPs) and/or milrinone (MIL) on renal ischemia/reperfusion injury (I/RI) in rats and their possible underlying mechanisms. Forty-eight adult male Sprague-Dawley albino rats were randomly assigned into six equal-sized groups (n = 8): normal control, sham-operated, I/R group (45 min/24 h), ZnO-NPs group (10 mg/kg i.p.), MIL group (0.5 mg/kg i.p.), and ZnO-NPs + MIL group in the same previous doses. In comparison to the I/R-operated group, administration of either ZnO-NPs or MIL significantly decreased serum creatinine and urea concentrations, and renal vascular permeability (p
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2023.121435