Aldehyde‐Based Inhibitors of the Peptidoglycan O‐Acetylesterase Ape

The O‐acetylation of the muramic acid residues in peptidoglycan (PG) is a modification that protects the bacteria from lysis due to the action of lysozyme. In Gram‐negative bacteria, deacetylation is required to allow lytic transglycosylases to promote PG cleavage during cell growth and division. Th...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2023-06, Vol.24 (11), p.e202300205-n/a
Hauptverfasser:	Voskoboinyk, Dmytro, Mahmoodi, Niusha, Lin, Chang Sheng‐Huei, Murphy, Michael E. P., Tanner, Martin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylesterase Adducts Aldehydes Aldehydes - pharmacology Animals antibiotic Bacteria Bacteria - metabolism Campylobacter jejuni Catalysis Deacetylation esterase Esterases - chemistry Gram-negative bacteria Hominidae - metabolism Inhibitors Lysis Lysozyme N-acetylmuramic acid peptidoglycan Peptidoglycan - chemistry Peptidoglycans reversible covalent inhibitor Serine Serine esterase Virulence
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