Endothelial progenitor cell-derived exosomes inhibit pulmonary artery smooth muscle cell in vitro proliferation and resistance to apoptosis by modulating the Mitofusin-2 and Ras-Raf-ERK1/2 signaling pathway

Pulmonary arterial hypertension (PAH) mainly occurs as a result of abnormal proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Endothelial progenitor cell (EPC)-derived exosomes (Exos) (EPC-Exos) relieve PAH. However, there is still insufficient knowledge of whe...

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Veröffentlicht in:	European journal of pharmacology 2023-06, Vol.949, p.175725-175725, Article 175725
Hauptverfasser:	Liu, Panpan, Gao, Shuai, Li, Zhixin, Pan, Silin, Luo, Gang, Ji, Zhixian
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Movement - genetics Cell Proliferation - genetics Endothelial Progenitor Cells - metabolism Exosomes Exosomes - metabolism Familial Primary Pulmonary Hypertension - pathology Humans Hypoxia - metabolism MAP Kinase Signaling System MicroRNAs - genetics MicroRNAs - metabolism Mitofusin-2 Myocytes, Smooth Muscle - metabolism Pulmonary arterial hypertension Pulmonary Arterial Hypertension - metabolism Pulmonary Artery - pathology Pulmonary artery smooth muscle cells Ras-Raf-ERK1/2 signaling pathway Signal Transduction
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