Increased peripapillary capillaries in patients with acute leukemia by using optical coherence tomography angiography
•Patients with acute leukemia in early-stage showed fundus changes compared with healthy control.•Patients in the acute leukemia group had an increased radial peripapillary capillary vessel density and a thicker retinal nerve fiber layer.•Fundus changes showed a significant negative correlation with...
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| Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2023-06, Vol.42, p.103569-103569, Article 103569 |
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| container_title | Photodiagnosis and photodynamic therapy |
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| creator | Zhou, Chong Zeng, Peng Wang, Jing Zhang, Yi Fan, Shu-xian Hu, Yu-xin Nie, Da-nian Xiao, Jian-hui |
| description | •Patients with acute leukemia in early-stage showed fundus changes compared with healthy control.•Patients in the acute leukemia group had an increased radial peripapillary capillary vessel density and a thicker retinal nerve fiber layer.•Fundus changes showed a significant negative correlation with red blood cells, hemoglobin and hematocrit.•Optical coherence tomography angiography images can detect these early fundus changes noninvasively and effectively.
To evaluate the radial peripapillary capillary vessel density (RPC-VD) and thickness of the retinal nerve fiber layer (RNFL) in acute leukemia (AL) and the associations of these characteristics with blood laboratory parameters.
A cross-sectional study was performed at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from February 2019 to April 2022. Sixty eyes of 30 patients diagnosed with AL and sixty eyes of 30 matched healthy controls were included. Optical coherence tomography angiography (OCTA) in the 4.5-mm Angio Disc scan mode and the Ganglion cell complex scan mode were performed for all participants. Correlation analyses were used to examine the associations of RPC-VD and RNFL with blood laboratory parameters.
Patients in the AL group had significantly increased RPC-VD in the whole-image (51.42±0.35 vs. 49.52±0.36) and peripapillary fields (53.90±0.43 vs. 51.17±0.50) compared with people in the control group (all P |
| doi_str_mv | 10.1016/j.pdpdt.2023.103569 |
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To evaluate the radial peripapillary capillary vessel density (RPC-VD) and thickness of the retinal nerve fiber layer (RNFL) in acute leukemia (AL) and the associations of these characteristics with blood laboratory parameters.
A cross-sectional study was performed at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from February 2019 to April 2022. Sixty eyes of 30 patients diagnosed with AL and sixty eyes of 30 matched healthy controls were included. Optical coherence tomography angiography (OCTA) in the 4.5-mm Angio Disc scan mode and the Ganglion cell complex scan mode were performed for all participants. Correlation analyses were used to examine the associations of RPC-VD and RNFL with blood laboratory parameters.
Patients in the AL group had significantly increased RPC-VD in the whole-image (51.42±0.35 vs. 49.52±0.36) and peripapillary fields (53.90±0.43 vs. 51.17±0.50) compared with people in the control group (all P<0.001), while no difference was found for RPC-VD in the inside optic disk fields in the two groups. The RNFL in the AL group was significantly thicker than that in the control group (131.10±3.89 μm vs. 115.03±2.22 μm, P<0.05). Complete blood count (CBC) parameters, including red blood cells, hemoglobin and hematocrit, had a significant negative correlation with RPC-VD and RNFL (all P <0.05).
An increased RPC-VD and a thicker RNFL are evidence of fundus changes in patients with early-stage AL, and these metrics may be related to decreases in red blood cells, hemoglobin and hematocrit.</description><identifier>ISSN: 1572-1000</identifier><identifier>EISSN: 1873-1597</identifier><identifier>DOI: 10.1016/j.pdpdt.2023.103569</identifier><identifier>PMID: 37068646</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute leukemia ; Blood laboratory parameters ; Microvascular densities ; Optical coherence tomography angiography ; Radial capillary density</subject><ispartof>Photodiagnosis and photodynamic therapy, 2023-06, Vol.42, p.103569-103569, Article 103569</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c309t-fa00663dfada3625de8d7a2a642fe9cf0c551b9bbc46362760de8f8ce25323f3</cites><orcidid>0000-0001-7882-9191</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pdpdt.2023.103569$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37068646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Chong</creatorcontrib><creatorcontrib>Zeng, Peng</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Fan, Shu-xian</creatorcontrib><creatorcontrib>Hu, Yu-xin</creatorcontrib><creatorcontrib>Nie, Da-nian</creatorcontrib><creatorcontrib>Xiao, Jian-hui</creatorcontrib><title>Increased peripapillary capillaries in patients with acute leukemia by using optical coherence tomography angiography</title><title>Photodiagnosis and photodynamic therapy</title><addtitle>Photodiagnosis Photodyn Ther</addtitle><description>•Patients with acute leukemia in early-stage showed fundus changes compared with healthy control.•Patients in the acute leukemia group had an increased radial peripapillary capillary vessel density and a thicker retinal nerve fiber layer.•Fundus changes showed a significant negative correlation with red blood cells, hemoglobin and hematocrit.•Optical coherence tomography angiography images can detect these early fundus changes noninvasively and effectively.
To evaluate the radial peripapillary capillary vessel density (RPC-VD) and thickness of the retinal nerve fiber layer (RNFL) in acute leukemia (AL) and the associations of these characteristics with blood laboratory parameters.
A cross-sectional study was performed at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from February 2019 to April 2022. Sixty eyes of 30 patients diagnosed with AL and sixty eyes of 30 matched healthy controls were included. Optical coherence tomography angiography (OCTA) in the 4.5-mm Angio Disc scan mode and the Ganglion cell complex scan mode were performed for all participants. Correlation analyses were used to examine the associations of RPC-VD and RNFL with blood laboratory parameters.
Patients in the AL group had significantly increased RPC-VD in the whole-image (51.42±0.35 vs. 49.52±0.36) and peripapillary fields (53.90±0.43 vs. 51.17±0.50) compared with people in the control group (all P<0.001), while no difference was found for RPC-VD in the inside optic disk fields in the two groups. The RNFL in the AL group was significantly thicker than that in the control group (131.10±3.89 μm vs. 115.03±2.22 μm, P<0.05). Complete blood count (CBC) parameters, including red blood cells, hemoglobin and hematocrit, had a significant negative correlation with RPC-VD and RNFL (all P <0.05).
An increased RPC-VD and a thicker RNFL are evidence of fundus changes in patients with early-stage AL, and these metrics may be related to decreases in red blood cells, hemoglobin and hematocrit.</description><subject>Acute leukemia</subject><subject>Blood laboratory parameters</subject><subject>Microvascular densities</subject><subject>Optical coherence tomography angiography</subject><subject>Radial capillary density</subject><issn>1572-1000</issn><issn>1873-1597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kD1v2zAQhomiQe24_QUBAo5d5J5IiZKGDkGQpAYMdPFOUOTJpqsPlqRS-N-Hrt2Ome7F8Tke7iHkLod1Drn4dlw740xcM2A8dXgpmg9kmdcVz_KyqT6mXFYsywFgQW5DOALwooHiE1nwCkQtCrEk82bUHlVAQx1665Szfa_8ieprshioHalT0eIYA_1j44EqPUekPc6_cLCKtic6Bzvu6eSi1aqnejqgx1EjjdMw7b1yhxNV495e82dy06k-4JdrXZHd89Pu8Ue2_fmyeXzYZppDE7NOAQjBTaeM4oKVBmtTKaZEwTpsdAe6LPO2aVtdiPReCUhEV2tkJWe84yvy9fKt89PvGUOUgw0a01kjTnOQrAZW1wWUTUL5BdV-CsFjJ523QxIhc5Bn3fIo_-qWZ93yojtN3V8XzO2A5v_MP78J-H4BMF35atHLoO1ZjLEedZRmsu8ueAMXg5Vl</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Zhou, Chong</creator><creator>Zeng, Peng</creator><creator>Wang, Jing</creator><creator>Zhang, Yi</creator><creator>Fan, Shu-xian</creator><creator>Hu, Yu-xin</creator><creator>Nie, Da-nian</creator><creator>Xiao, Jian-hui</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7882-9191</orcidid></search><sort><creationdate>202306</creationdate><title>Increased peripapillary capillaries in patients with acute leukemia by using optical coherence tomography angiography</title><author>Zhou, Chong ; Zeng, Peng ; Wang, Jing ; Zhang, Yi ; Fan, Shu-xian ; Hu, Yu-xin ; Nie, Da-nian ; Xiao, Jian-hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-fa00663dfada3625de8d7a2a642fe9cf0c551b9bbc46362760de8f8ce25323f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute leukemia</topic><topic>Blood laboratory parameters</topic><topic>Microvascular densities</topic><topic>Optical coherence tomography angiography</topic><topic>Radial capillary density</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Chong</creatorcontrib><creatorcontrib>Zeng, Peng</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Fan, Shu-xian</creatorcontrib><creatorcontrib>Hu, Yu-xin</creatorcontrib><creatorcontrib>Nie, Da-nian</creatorcontrib><creatorcontrib>Xiao, Jian-hui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Chong</au><au>Zeng, Peng</au><au>Wang, Jing</au><au>Zhang, Yi</au><au>Fan, Shu-xian</au><au>Hu, Yu-xin</au><au>Nie, Da-nian</au><au>Xiao, Jian-hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased peripapillary capillaries in patients with acute leukemia by using optical coherence tomography angiography</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2023-06</date><risdate>2023</risdate><volume>42</volume><spage>103569</spage><epage>103569</epage><pages>103569-103569</pages><artnum>103569</artnum><issn>1572-1000</issn><eissn>1873-1597</eissn><abstract>•Patients with acute leukemia in early-stage showed fundus changes compared with healthy control.•Patients in the acute leukemia group had an increased radial peripapillary capillary vessel density and a thicker retinal nerve fiber layer.•Fundus changes showed a significant negative correlation with red blood cells, hemoglobin and hematocrit.•Optical coherence tomography angiography images can detect these early fundus changes noninvasively and effectively.
To evaluate the radial peripapillary capillary vessel density (RPC-VD) and thickness of the retinal nerve fiber layer (RNFL) in acute leukemia (AL) and the associations of these characteristics with blood laboratory parameters.
A cross-sectional study was performed at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from February 2019 to April 2022. Sixty eyes of 30 patients diagnosed with AL and sixty eyes of 30 matched healthy controls were included. Optical coherence tomography angiography (OCTA) in the 4.5-mm Angio Disc scan mode and the Ganglion cell complex scan mode were performed for all participants. Correlation analyses were used to examine the associations of RPC-VD and RNFL with blood laboratory parameters.
Patients in the AL group had significantly increased RPC-VD in the whole-image (51.42±0.35 vs. 49.52±0.36) and peripapillary fields (53.90±0.43 vs. 51.17±0.50) compared with people in the control group (all P<0.001), while no difference was found for RPC-VD in the inside optic disk fields in the two groups. The RNFL in the AL group was significantly thicker than that in the control group (131.10±3.89 μm vs. 115.03±2.22 μm, P<0.05). Complete blood count (CBC) parameters, including red blood cells, hemoglobin and hematocrit, had a significant negative correlation with RPC-VD and RNFL (all P <0.05).
An increased RPC-VD and a thicker RNFL are evidence of fundus changes in patients with early-stage AL, and these metrics may be related to decreases in red blood cells, hemoglobin and hematocrit.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37068646</pmid><doi>10.1016/j.pdpdt.2023.103569</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7882-9191</orcidid></addata></record> |
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| subjects | Acute leukemia Blood laboratory parameters Microvascular densities Optical coherence tomography angiography Radial capillary density |
| title | Increased peripapillary capillaries in patients with acute leukemia by using optical coherence tomography angiography |
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