Chronic hyperadiponectinemia induced by transgenic overexpression increases plasma exosomes without significantly improving glucose and lipid metabolism

The fat-derived factor, adiponectin, is considered a salutary circulating factor. We recently demonstrated that native adiponectin binds T-cadherin and promotes intracellular biogenesis and secretion of the exosome. Exosomes play important roles in various aspects of homeostasis, including glucose a...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2023, Vol.70(6), pp.635-645
Hauptverfasser:	Kawada, Keitaro, Kita, Shunbun, Fukuda, Shiro, Fukuoka, Keita, Okita, Tomonori, Kawada-Horitani, Emi, Iioka, Masahito, Sakaue, Taka-aki, Kawachi, Yusuke, Fujii, Kohei, Kimura, Yu, Otabe, Shuichi, Fujishima, Yuya, Nishizawa, Hitoshi, Maeda, Norikazu, Shimomura, Iichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Energy metabolism Exosomes Extracellular vesicles Fat metabolism Glucose metabolism High fat diet Homeostasis Lipid metabolism Streptozocin T-cadherin Transgenic mice
Online-Zugang:	Volltext
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