Heterogeneity in the immune microenvironment of bone metastasis in driver‐positive non‐small cell lung cancer

Mutations in epidermal growth factor receptor and anaplastic lymphoma kinase are common driver events in non‐small cell lung cancer (NSCLC), which are associated with a high frequency of bone metastases (BMs). While the bone marrow represents a specialized immune microenvironment, the immune reperto...

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Veröffentlicht in:	Molecular carcinogenesis 2023-07, Vol.62 (7), p.1001-1008
Hauptverfasser:	Yang, Xiao‐Rong, Pi, Can, Zhang, Yi‐Chen, Chen, Zhi‐Hong, Zhang, Xu‐Chao, Zhu, Dong‐Qin, Yang, Ling‐Ling, Yin, Jiani C., Deng, Jia‐Yi, Yang, Ming‐Yi, Luo, Wei‐Chi, Wu, Yi‐Long, Zhou, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow bone metastasis Clinical outcomes Cytotoxicity driver gene Epidermal growth factor Gene expression Immune checkpoint inhibitors Kinases Lung cancer Lymphocytes T Macrophages Metastases Microenvironments Mutation Natural killer cells Non-small cell lung carcinoma NSCLC Protein-tyrosine kinase Small cell lung carcinoma T cell receptors TCR repertoire tumor immune microenvironment
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