A View on Drug Development for Cancer Prevention
Despite some notable successes, there are still relatively few agents approved for cancer prevention. Here we review progress thus far in the development of medicines for cancer prevention, and we outline some key concepts that could further enable or accelerate drug development for cancer preventio...
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| Veröffentlicht in: | Cancer discovery 2023-05, Vol.13 (5), p.1058-1083 |
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| container_title | Cancer discovery |
| container_volume | 13 |
| creator | Reynolds, Andrew R Moschetta, Michele Yohannes, Alula R Walcott, Farzana Ashford, Marianne Szucs, Zoltan Sarbajna, Tina Hadfield, James Harrison, Eden Challis, Benjamin G Hernandez, Amaya Gasco Schiavon, Gaia Germa, Caroline Zorenyi, Gyorgy Crean, Barry Galbraith, Susan |
| description | Despite some notable successes, there are still relatively few agents approved for cancer prevention. Here we review progress thus far in the development of medicines for cancer prevention, and we outline some key concepts that could further enable or accelerate drug development for cancer prevention in the future. These are summarized under six key themes: (i) unmet clinical need, (ii) patient identification, (iii) risk stratification, (iv) pharmacological intervention, (v) clinical trials, and (vi) health care policy. These concepts, if successfully realized, may help to increase the number of medicines available for cancer prevention.
The huge potential public health benefits of preventing cancer, combined with recent advances in the availability of novel early detection technologies and new treatment modalities, has caused us to revisit the opportunities and challenges associated with developing medicines to prevent cancer. Here we review progress in the field of developing medicines to prevent cancer to date, and we present a series of ideas that might help in the development of more medicines to prevent cancer in the future. |
| doi_str_mv | 10.1158/2159-8290.CD-22-0776 |
| format | Article |
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The huge potential public health benefits of preventing cancer, combined with recent advances in the availability of novel early detection technologies and new treatment modalities, has caused us to revisit the opportunities and challenges associated with developing medicines to prevent cancer. Here we review progress in the field of developing medicines to prevent cancer to date, and we present a series of ideas that might help in the development of more medicines to prevent cancer in the future.</description><identifier>ISSN: 2159-8274</identifier><identifier>EISSN: 2159-8290</identifier><identifier>DOI: 10.1158/2159-8290.CD-22-0776</identifier><identifier>PMID: 37067191</identifier><language>eng</language><publisher>United States</publisher><subject>Drug Development ; Humans ; Neoplasms - drug therapy ; Neoplasms - prevention & control</subject><ispartof>Cancer discovery, 2023-05, Vol.13 (5), p.1058-1083</ispartof><rights>2023 American Association for Cancer Research.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-87246f5bd643b29ad45398bef92c9ae3fcf37059fec02a348236a419155cbad23</citedby><cites>FETCH-LOGICAL-c353t-87246f5bd643b29ad45398bef92c9ae3fcf37059fec02a348236a419155cbad23</cites><orcidid>0000-0003-4370-1723 ; 0000-0002-8479-7891 ; 0000-0001-9868-4989 ; 0000-0002-1469-976X ; 0000-0002-2838-9076 ; 0000-0002-9119-4642 ; 0000-0002-9699-637X ; 0000-0003-0779-6972 ; 0000-0002-6325-0846 ; 0000-0002-8390-4800 ; 0000-0002-1130-2851 ; 0000-0001-9059-8971 ; 0000-0002-8080-3545 ; 0000-0003-4606-343X ; 0000-0001-6547-2568 ; 0000-0001-9505-8835</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37067191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reynolds, Andrew R</creatorcontrib><creatorcontrib>Moschetta, Michele</creatorcontrib><creatorcontrib>Yohannes, Alula R</creatorcontrib><creatorcontrib>Walcott, Farzana</creatorcontrib><creatorcontrib>Ashford, Marianne</creatorcontrib><creatorcontrib>Szucs, Zoltan</creatorcontrib><creatorcontrib>Sarbajna, Tina</creatorcontrib><creatorcontrib>Hadfield, James</creatorcontrib><creatorcontrib>Harrison, Eden</creatorcontrib><creatorcontrib>Challis, Benjamin G</creatorcontrib><creatorcontrib>Hernandez, Amaya Gasco</creatorcontrib><creatorcontrib>Schiavon, Gaia</creatorcontrib><creatorcontrib>Germa, Caroline</creatorcontrib><creatorcontrib>Zorenyi, Gyorgy</creatorcontrib><creatorcontrib>Crean, Barry</creatorcontrib><creatorcontrib>Galbraith, Susan</creatorcontrib><title>A View on Drug Development for Cancer Prevention</title><title>Cancer discovery</title><addtitle>Cancer Discov</addtitle><description>Despite some notable successes, there are still relatively few agents approved for cancer prevention. Here we review progress thus far in the development of medicines for cancer prevention, and we outline some key concepts that could further enable or accelerate drug development for cancer prevention in the future. These are summarized under six key themes: (i) unmet clinical need, (ii) patient identification, (iii) risk stratification, (iv) pharmacological intervention, (v) clinical trials, and (vi) health care policy. These concepts, if successfully realized, may help to increase the number of medicines available for cancer prevention.
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| fulltext | fulltext |
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| ispartof | Cancer discovery, 2023-05, Vol.13 (5), p.1058-1083 |
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| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Drug Development Humans Neoplasms - drug therapy Neoplasms - prevention & control |
| title | A View on Drug Development for Cancer Prevention |
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