Independent human mesenchymal stromal cell–derived extracellular vesicle preparations differentially attenuate symptoms in an advanced murine graft-versus-host disease model

Extracellular vesicles (EVs) harvested from conditioned media of human mesenchymal stromal cells (MSCs) suppress acute inflammation in various disease models and promote regeneration of damaged tissues. After successful treatment of a patient with acute steroid-refractory graft-versus-host disease (...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2023-08, Vol.25 (8), p.821-836
Hauptverfasser:	Madel, Rabea J., Börger, Verena, Dittrich, Robin, Bremer, Michel, Tertel, Tobias, Phuong, Nhi Ngo Thi, Baba, Hideo A., Kordelas, Lambros, Staubach, Simon, Stein, Frank, Haberkant, Per, Hackl, Matthias, Grillari, Regina, Grillari, Johannes, Buer, Jan, Horn, Peter A., Westendorf, Astrid M., Brandau, Sven, Kirschning, Carsten J., Giebel, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Culture Media, Conditioned - metabolism exosomes extracellular vesicles Extracellular Vesicles - metabolism Graft vs Host Disease - therapy graft-versus-host disease heterogeneity Humans mesenchymal stem cells Mesenchymal Stem Cells - metabolism mesenchymal stromal cells Mice MicroRNAs - genetics MicroRNAs - metabolism
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