Impact of prior flavivirus vaccination on immunogenicity and efficacy of an inactivated Zika vaccine in Indian rhesus macaques

Flaviviruses are antigenically related. We evaluated the immunogenicity and efficacy of Takeda’s purified inactivated Zika vaccine (PIZV) candidate in macaques previously vaccinated with several commercially available heterologous flavivirus vaccines. Heterologous flavivirus vaccination did not elic...

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Veröffentlicht in:	Vaccine 2023-05, Vol.41 (19), p.3024-3027
Hauptverfasser:	Young, Ginger, Zahralban-Steele, Melissa, Dean, Hansi J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Neutralizing Antibodies, Viral Antigens Deactivation Dengue fever Effectiveness Efficacy Encephalitis Flavivirus Immunogenicity Immunogenicity, Vaccine Infections Macaca mulatta Neutralizing Pre-existing immunity Vaccination Vaccines Vaccines, Inactivated Vector-borne diseases Viral Vaccines Viremia Viruses West Nile virus Zika Virus Zika Virus Infection
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