Combined Dyslipidemia in Children and Adolescents: a Proposed New Management Approach
Purpose of Review Combined dyslipidemia (CD), the predominant abnormal lipid pattern in children and adolescents, is characterized by moderate/severe triglyceride elevation with reduced high-density lipoprotein cholesterol. CD is prevalent, present in 30–50% of obese adolescents. Epidemiologic and l...
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| Veröffentlicht in: | Current atherosclerosis reports 2023-05, Vol.25 (5), p.237-245 |
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| creator | Kavey, Rae-Ellen W. |
| description | Purpose of Review
Combined dyslipidemia (CD), the predominant abnormal lipid pattern in children and adolescents, is characterized by moderate/severe triglyceride elevation with reduced high-density lipoprotein cholesterol. CD is prevalent, present in 30–50% of obese adolescents. Epidemiologic and lipid sub-population findings demonstrate CD to be highly atherogenic. In the short term, CD responds well to lifestyle change; long-term results are lacking.
Recent Findings
Major longitudinal studies now confirm that CD in childhood predicts early cardiovascular disease events in adults. Targeted nutritional interventions can be safely and effectively introduced in young children. These findings support introduction of a new approach to CD management.
Summary
New evidence supporting the atherosclerotic risk associated with CD and the effectiveness of lifelong diet interventions is reviewed and a new family-based primordial approach to CD beginning in infancy is proposed. Aligned with existing pediatric care recommendations, this has the potential to significantly decrease the development of CD. |
| doi_str_mv | 10.1007/s11883-023-01099-x |
| format | Article |
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Combined dyslipidemia (CD), the predominant abnormal lipid pattern in children and adolescents, is characterized by moderate/severe triglyceride elevation with reduced high-density lipoprotein cholesterol. CD is prevalent, present in 30–50% of obese adolescents. Epidemiologic and lipid sub-population findings demonstrate CD to be highly atherogenic. In the short term, CD responds well to lifestyle change; long-term results are lacking.
Recent Findings
Major longitudinal studies now confirm that CD in childhood predicts early cardiovascular disease events in adults. Targeted nutritional interventions can be safely and effectively introduced in young children. These findings support introduction of a new approach to CD management.
Summary
New evidence supporting the atherosclerotic risk associated with CD and the effectiveness of lifelong diet interventions is reviewed and a new family-based primordial approach to CD beginning in infancy is proposed. Aligned with existing pediatric care recommendations, this has the potential to significantly decrease the development of CD.</description><identifier>ISSN: 1523-3804</identifier><identifier>EISSN: 1534-6242</identifier><identifier>DOI: 10.1007/s11883-023-01099-x</identifier><identifier>PMID: 37058165</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Adult ; Angiology ; Atherosclerosis - complications ; Atherosclerosis - epidemiology ; Atherosclerosis - therapy ; Cardiology ; Child ; Child, Preschool ; Cholesterol ; Dyslipidemias - complications ; Dyslipidemias - epidemiology ; Dyslipidemias - therapy ; Humans ; Medicine ; Medicine & Public Health ; Obesity - complications ; Topical Collection on Children/Adolescents/Young Adults and Atherosclerosis ; Triglycerides</subject><ispartof>Current atherosclerosis reports, 2023-05, Vol.25 (5), p.237-245</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-2f4e6055f6b6930ccc79b232e7a7b9c92bf34d9916009372eff13d47a1b251963</cites><orcidid>0000-0001-6150-5887</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11883-023-01099-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11883-023-01099-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37058165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kavey, Rae-Ellen W.</creatorcontrib><title>Combined Dyslipidemia in Children and Adolescents: a Proposed New Management Approach</title><title>Current atherosclerosis reports</title><addtitle>Curr Atheroscler Rep</addtitle><addtitle>Curr Atheroscler Rep</addtitle><description>Purpose of Review
Combined dyslipidemia (CD), the predominant abnormal lipid pattern in children and adolescents, is characterized by moderate/severe triglyceride elevation with reduced high-density lipoprotein cholesterol. CD is prevalent, present in 30–50% of obese adolescents. Epidemiologic and lipid sub-population findings demonstrate CD to be highly atherogenic. In the short term, CD responds well to lifestyle change; long-term results are lacking.
Recent Findings
Major longitudinal studies now confirm that CD in childhood predicts early cardiovascular disease events in adults. Targeted nutritional interventions can be safely and effectively introduced in young children. These findings support introduction of a new approach to CD management.
Summary
New evidence supporting the atherosclerotic risk associated with CD and the effectiveness of lifelong diet interventions is reviewed and a new family-based primordial approach to CD beginning in infancy is proposed. Aligned with existing pediatric care recommendations, this has the potential to significantly decrease the development of CD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Angiology</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - epidemiology</subject><subject>Atherosclerosis - therapy</subject><subject>Cardiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cholesterol</subject><subject>Dyslipidemias - complications</subject><subject>Dyslipidemias - epidemiology</subject><subject>Dyslipidemias - therapy</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity - complications</subject><subject>Topical Collection on Children/Adolescents/Young Adults and Atherosclerosis</subject><subject>Triglycerides</subject><issn>1523-3804</issn><issn>1534-6242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwyAYx4nROJ1-AQ-Go5cqL20p3pb5msyXgzsTCnTr0kKFNW7fXmanRw_kIfm_wPMD4AKja4wQuwkYFwVNEIkHI86TzQE4wRlNk5yk5HB3jxItUDoCpyGsECKoyPExGFGGsgLn2QmYT11b1tZoeLcNTd3V2rS1hLWF02XdaG8slFbDiXaNCcrYdbiFEr5717kQQ6_mC75IKxemjRqcdJ13Ui3PwFElm2DO93MM5g_3H9OnZPb2-DydzBJFeLFOSJWaHGVZlZc5p0gpxXhJKDFMspIrTsqKpppznCPEKSOmqjDVKZO4JBnmOR2Dq6E3PvvZm7AWbR1_2TTSGtcHQQqEOeM4pdFKBqvyLgRvKtH5upV-KzASO5xiwCkiTvGDU2xi6HLf35et0X-RX37RQAdDiJJdGC9Wrvc27vxf7TdB1H_4</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Kavey, Rae-Ellen W.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6150-5887</orcidid></search><sort><creationdate>20230501</creationdate><title>Combined Dyslipidemia in Children and Adolescents: a Proposed New Management Approach</title><author>Kavey, Rae-Ellen W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-2f4e6055f6b6930ccc79b232e7a7b9c92bf34d9916009372eff13d47a1b251963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Angiology</topic><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - epidemiology</topic><topic>Atherosclerosis - therapy</topic><topic>Cardiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cholesterol</topic><topic>Dyslipidemias - complications</topic><topic>Dyslipidemias - epidemiology</topic><topic>Dyslipidemias - therapy</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity - complications</topic><topic>Topical Collection on Children/Adolescents/Young Adults and Atherosclerosis</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kavey, Rae-Ellen W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current atherosclerosis reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kavey, Rae-Ellen W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined Dyslipidemia in Children and Adolescents: a Proposed New Management Approach</atitle><jtitle>Current atherosclerosis reports</jtitle><stitle>Curr Atheroscler Rep</stitle><addtitle>Curr Atheroscler Rep</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>25</volume><issue>5</issue><spage>237</spage><epage>245</epage><pages>237-245</pages><issn>1523-3804</issn><eissn>1534-6242</eissn><abstract>Purpose of Review
Combined dyslipidemia (CD), the predominant abnormal lipid pattern in children and adolescents, is characterized by moderate/severe triglyceride elevation with reduced high-density lipoprotein cholesterol. CD is prevalent, present in 30–50% of obese adolescents. Epidemiologic and lipid sub-population findings demonstrate CD to be highly atherogenic. In the short term, CD responds well to lifestyle change; long-term results are lacking.
Recent Findings
Major longitudinal studies now confirm that CD in childhood predicts early cardiovascular disease events in adults. Targeted nutritional interventions can be safely and effectively introduced in young children. These findings support introduction of a new approach to CD management.
Summary
New evidence supporting the atherosclerotic risk associated with CD and the effectiveness of lifelong diet interventions is reviewed and a new family-based primordial approach to CD beginning in infancy is proposed. Aligned with existing pediatric care recommendations, this has the potential to significantly decrease the development of CD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37058165</pmid><doi>10.1007/s11883-023-01099-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6150-5887</orcidid></addata></record> |
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| ispartof | Current atherosclerosis reports, 2023-05, Vol.25 (5), p.237-245 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Angiology Atherosclerosis - complications Atherosclerosis - epidemiology Atherosclerosis - therapy Cardiology Child Child, Preschool Cholesterol Dyslipidemias - complications Dyslipidemias - epidemiology Dyslipidemias - therapy Humans Medicine Medicine & Public Health Obesity - complications Topical Collection on Children/Adolescents/Young Adults and Atherosclerosis Triglycerides |
| title | Combined Dyslipidemia in Children and Adolescents: a Proposed New Management Approach |
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