Estimating kidney function in patients with cancer: A narrative review

Aim Accurate evaluation of glomerular filtration rate (GFR) is crucial in Oncology as drug eligibility and dosing depend on estimates of GFR. However, there are no clear guidelines on the optimal method of determining kidney function in patients with cancer. We aimed to summarize the evidence on est...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta Physiologica 2023-06, Vol.238 (2), p.e13977-n/a
Hauptverfasser: Claudel, Sophie E., Gandhi, Malini, Patel, Ankit B., Verma, Ashish
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page n/a
container_issue 2
container_start_page e13977
container_title Acta Physiologica
container_volume 238
creator Claudel, Sophie E.
Gandhi, Malini
Patel, Ankit B.
Verma, Ashish
description Aim Accurate evaluation of glomerular filtration rate (GFR) is crucial in Oncology as drug eligibility and dosing depend on estimates of GFR. However, there are no clear guidelines on the optimal method of determining kidney function in patients with cancer. We aimed to summarize the evidence on estimation of kidney function in patients with cancer. Methods We searched PubMed for literature discussing the performance of GFR estimating equations in patients with malignancy to create a table of the evidence for creatinine‐ and cystatin c‐based equations. We further reviewed novel estimation techniques such as panel eGFR, real‐time measured GFR, and functional magnetic resonance imaging. Results The commonly used GFR estimating equations were derived from populations of patients without cancer. These equations may be less applicable in Oncology due to severe sarcopenia, inflammation, and other physiologic changes in patients with cancer. The Cockcroft‐Gault equation currently dominates in clinical Oncology despite significant limitations and accumulating evidence for use of the CKD‐EPICr formula. Additional considerations in the practice of Oncology include a recently developed equation (CamGFRv2, also called the Janowitz formula) and the use of cystatin c‐based equations to overcome some of the barriers to accurate GFR estimation based on creatinine alone. Conclusion Overall, we suggest using the CKD‐EPI equations (either cystatin c or creatinine‐based) among patients with cancer in routine clinical practice and measured GFR for patients at a critical threshold for treatment decisions.
doi_str_mv 10.1111/apha.13977
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2801978243</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2801978243</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3577-637f35a1fea7fbf704f1afdfff8e6543a7feec44e3c0a8de2a51178c2990b2723</originalsourceid><addsrcrecordid>eNp9kE1PAjEQhhujEYJc_AGmiRdjAvZjl-562xAQExI96LkpZSpF6K7tLoR_bxHk4MG5zGTmyZvJg9A1JX0a60FVC9WnPBfiDLWpSLIeFXRwfppJ1kLdEJaEEMooTxi7RC0uSCryPGuj8SjUdq1q6z7wp5072GHTOF3b0mHrcBUv4OqAt7ZeYK2cBv-IC-yU9_G0AexhY2F7hS6MWgXoHnsHvY9Hb8NJb_ry9Dwspj3NUyF6Ay4MTxU1oISZGUESQ5WZG2MyGKQJj1sAnSTANVHZHJhKKRWZZnlOZkww3kF3h9zKl18NhFqubdCwWikHZRMkywjNRcYSHtHbP-iybLyL30WKJowIlpNI3R8o7csQPBhZ-ejD7yQlci9Y7gXLH8ERvjlGNrM1zE_or84I0AOwtSvY_RMli9dJcQj9BuqyhQU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2814207290</pqid></control><display><type>article</type><title>Estimating kidney function in patients with cancer: A narrative review</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Claudel, Sophie E. ; Gandhi, Malini ; Patel, Ankit B. ; Verma, Ashish</creator><creatorcontrib>Claudel, Sophie E. ; Gandhi, Malini ; Patel, Ankit B. ; Verma, Ashish</creatorcontrib><description>Aim Accurate evaluation of glomerular filtration rate (GFR) is crucial in Oncology as drug eligibility and dosing depend on estimates of GFR. However, there are no clear guidelines on the optimal method of determining kidney function in patients with cancer. We aimed to summarize the evidence on estimation of kidney function in patients with cancer. Methods We searched PubMed for literature discussing the performance of GFR estimating equations in patients with malignancy to create a table of the evidence for creatinine‐ and cystatin c‐based equations. We further reviewed novel estimation techniques such as panel eGFR, real‐time measured GFR, and functional magnetic resonance imaging. Results The commonly used GFR estimating equations were derived from populations of patients without cancer. These equations may be less applicable in Oncology due to severe sarcopenia, inflammation, and other physiologic changes in patients with cancer. The Cockcroft‐Gault equation currently dominates in clinical Oncology despite significant limitations and accumulating evidence for use of the CKD‐EPICr formula. Additional considerations in the practice of Oncology include a recently developed equation (CamGFRv2, also called the Janowitz formula) and the use of cystatin c‐based equations to overcome some of the barriers to accurate GFR estimation based on creatinine alone. Conclusion Overall, we suggest using the CKD‐EPI equations (either cystatin c or creatinine‐based) among patients with cancer in routine clinical practice and measured GFR for patients at a critical threshold for treatment decisions.</description><identifier>ISSN: 1748-1708</identifier><identifier>EISSN: 1748-1716</identifier><identifier>DOI: 10.1111/apha.13977</identifier><identifier>PMID: 37057998</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Cancer ; clinical oncology ; Creatinine ; Cystatin C ; estimated glomerular filtration rate ; Functional magnetic resonance imaging ; Glomerular filtration rate ; Glomerular Filtration Rate - physiology ; Humans ; Kidney ; kidney function ; Kidneys ; Magnetic resonance imaging ; Malignancy ; measured glomerular filtration rate ; Neoplasms ; Oncology ; Patients ; Renal Insufficiency, Chronic ; Sarcopenia</subject><ispartof>Acta Physiologica, 2023-06, Vol.238 (2), p.e13977-n/a</ispartof><rights>2023 Scandinavian Physiological Society. Published by John Wiley &amp; Sons Ltd</rights><rights>2023 Scandinavian Physiological Society. Published by John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2023 Scandinavian Physiological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3577-637f35a1fea7fbf704f1afdfff8e6543a7feec44e3c0a8de2a51178c2990b2723</citedby><cites>FETCH-LOGICAL-c3577-637f35a1fea7fbf704f1afdfff8e6543a7feec44e3c0a8de2a51178c2990b2723</cites><orcidid>0000-0002-7695-4674 ; 0000-0001-9497-6327</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapha.13977$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapha.13977$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37057998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Claudel, Sophie E.</creatorcontrib><creatorcontrib>Gandhi, Malini</creatorcontrib><creatorcontrib>Patel, Ankit B.</creatorcontrib><creatorcontrib>Verma, Ashish</creatorcontrib><title>Estimating kidney function in patients with cancer: A narrative review</title><title>Acta Physiologica</title><addtitle>Acta Physiol (Oxf)</addtitle><description>Aim Accurate evaluation of glomerular filtration rate (GFR) is crucial in Oncology as drug eligibility and dosing depend on estimates of GFR. However, there are no clear guidelines on the optimal method of determining kidney function in patients with cancer. We aimed to summarize the evidence on estimation of kidney function in patients with cancer. Methods We searched PubMed for literature discussing the performance of GFR estimating equations in patients with malignancy to create a table of the evidence for creatinine‐ and cystatin c‐based equations. We further reviewed novel estimation techniques such as panel eGFR, real‐time measured GFR, and functional magnetic resonance imaging. Results The commonly used GFR estimating equations were derived from populations of patients without cancer. These equations may be less applicable in Oncology due to severe sarcopenia, inflammation, and other physiologic changes in patients with cancer. The Cockcroft‐Gault equation currently dominates in clinical Oncology despite significant limitations and accumulating evidence for use of the CKD‐EPICr formula. Additional considerations in the practice of Oncology include a recently developed equation (CamGFRv2, also called the Janowitz formula) and the use of cystatin c‐based equations to overcome some of the barriers to accurate GFR estimation based on creatinine alone. Conclusion Overall, we suggest using the CKD‐EPI equations (either cystatin c or creatinine‐based) among patients with cancer in routine clinical practice and measured GFR for patients at a critical threshold for treatment decisions.</description><subject>Cancer</subject><subject>clinical oncology</subject><subject>Creatinine</subject><subject>Cystatin C</subject><subject>estimated glomerular filtration rate</subject><subject>Functional magnetic resonance imaging</subject><subject>Glomerular filtration rate</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Kidney</subject><subject>kidney function</subject><subject>Kidneys</subject><subject>Magnetic resonance imaging</subject><subject>Malignancy</subject><subject>measured glomerular filtration rate</subject><subject>Neoplasms</subject><subject>Oncology</subject><subject>Patients</subject><subject>Renal Insufficiency, Chronic</subject><subject>Sarcopenia</subject><issn>1748-1708</issn><issn>1748-1716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PAjEQhhujEYJc_AGmiRdjAvZjl-562xAQExI96LkpZSpF6K7tLoR_bxHk4MG5zGTmyZvJg9A1JX0a60FVC9WnPBfiDLWpSLIeFXRwfppJ1kLdEJaEEMooTxi7RC0uSCryPGuj8SjUdq1q6z7wp5072GHTOF3b0mHrcBUv4OqAt7ZeYK2cBv-IC-yU9_G0AexhY2F7hS6MWgXoHnsHvY9Hb8NJb_ry9Dwspj3NUyF6Ay4MTxU1oISZGUESQ5WZG2MyGKQJj1sAnSTANVHZHJhKKRWZZnlOZkww3kF3h9zKl18NhFqubdCwWikHZRMkywjNRcYSHtHbP-iybLyL30WKJowIlpNI3R8o7csQPBhZ-ejD7yQlci9Y7gXLH8ERvjlGNrM1zE_or84I0AOwtSvY_RMli9dJcQj9BuqyhQU</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Claudel, Sophie E.</creator><creator>Gandhi, Malini</creator><creator>Patel, Ankit B.</creator><creator>Verma, Ashish</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7695-4674</orcidid><orcidid>https://orcid.org/0000-0001-9497-6327</orcidid></search><sort><creationdate>202306</creationdate><title>Estimating kidney function in patients with cancer: A narrative review</title><author>Claudel, Sophie E. ; Gandhi, Malini ; Patel, Ankit B. ; Verma, Ashish</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3577-637f35a1fea7fbf704f1afdfff8e6543a7feec44e3c0a8de2a51178c2990b2723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer</topic><topic>clinical oncology</topic><topic>Creatinine</topic><topic>Cystatin C</topic><topic>estimated glomerular filtration rate</topic><topic>Functional magnetic resonance imaging</topic><topic>Glomerular filtration rate</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Humans</topic><topic>Kidney</topic><topic>kidney function</topic><topic>Kidneys</topic><topic>Magnetic resonance imaging</topic><topic>Malignancy</topic><topic>measured glomerular filtration rate</topic><topic>Neoplasms</topic><topic>Oncology</topic><topic>Patients</topic><topic>Renal Insufficiency, Chronic</topic><topic>Sarcopenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Claudel, Sophie E.</creatorcontrib><creatorcontrib>Gandhi, Malini</creatorcontrib><creatorcontrib>Patel, Ankit B.</creatorcontrib><creatorcontrib>Verma, Ashish</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Physiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Claudel, Sophie E.</au><au>Gandhi, Malini</au><au>Patel, Ankit B.</au><au>Verma, Ashish</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimating kidney function in patients with cancer: A narrative review</atitle><jtitle>Acta Physiologica</jtitle><addtitle>Acta Physiol (Oxf)</addtitle><date>2023-06</date><risdate>2023</risdate><volume>238</volume><issue>2</issue><spage>e13977</spage><epage>n/a</epage><pages>e13977-n/a</pages><issn>1748-1708</issn><eissn>1748-1716</eissn><abstract>Aim Accurate evaluation of glomerular filtration rate (GFR) is crucial in Oncology as drug eligibility and dosing depend on estimates of GFR. However, there are no clear guidelines on the optimal method of determining kidney function in patients with cancer. We aimed to summarize the evidence on estimation of kidney function in patients with cancer. Methods We searched PubMed for literature discussing the performance of GFR estimating equations in patients with malignancy to create a table of the evidence for creatinine‐ and cystatin c‐based equations. We further reviewed novel estimation techniques such as panel eGFR, real‐time measured GFR, and functional magnetic resonance imaging. Results The commonly used GFR estimating equations were derived from populations of patients without cancer. These equations may be less applicable in Oncology due to severe sarcopenia, inflammation, and other physiologic changes in patients with cancer. The Cockcroft‐Gault equation currently dominates in clinical Oncology despite significant limitations and accumulating evidence for use of the CKD‐EPICr formula. Additional considerations in the practice of Oncology include a recently developed equation (CamGFRv2, also called the Janowitz formula) and the use of cystatin c‐based equations to overcome some of the barriers to accurate GFR estimation based on creatinine alone. Conclusion Overall, we suggest using the CKD‐EPI equations (either cystatin c or creatinine‐based) among patients with cancer in routine clinical practice and measured GFR for patients at a critical threshold for treatment decisions.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37057998</pmid><doi>10.1111/apha.13977</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-7695-4674</orcidid><orcidid>https://orcid.org/0000-0001-9497-6327</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1748-1708
ispartof Acta Physiologica, 2023-06, Vol.238 (2), p.e13977-n/a
issn 1748-1708
1748-1716
language eng
recordid cdi_proquest_miscellaneous_2801978243
source MEDLINE; Access via Wiley Online Library
subjects Cancer
clinical oncology
Creatinine
Cystatin C
estimated glomerular filtration rate
Functional magnetic resonance imaging
Glomerular filtration rate
Glomerular Filtration Rate - physiology
Humans
Kidney
kidney function
Kidneys
Magnetic resonance imaging
Malignancy
measured glomerular filtration rate
Neoplasms
Oncology
Patients
Renal Insufficiency, Chronic
Sarcopenia
title Estimating kidney function in patients with cancer: A narrative review
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A37%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Estimating%20kidney%20function%20in%20patients%20with%20cancer:%20A%20narrative%20review&rft.jtitle=Acta%20Physiologica&rft.au=Claudel,%20Sophie%20E.&rft.date=2023-06&rft.volume=238&rft.issue=2&rft.spage=e13977&rft.epage=n/a&rft.pages=e13977-n/a&rft.issn=1748-1708&rft.eissn=1748-1716&rft_id=info:doi/10.1111/apha.13977&rft_dat=%3Cproquest_cross%3E2801978243%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2814207290&rft_id=info:pmid/37057998&rfr_iscdi=true