Inhibitory interaction of flavonoids with organic cation transporter 2 and their structure-activity relationships for predicting nephroprotective effects

Organic cation transporter 2 (OCT2) is mainly responsible for the renal secretion of various cationic drugs, closely associated with drug-induced acute kidney injury (AKI). Screening and identifying potent OCT2 inhibitors with little toxicity in natural products in reducing OCT2-mediated AKI is of g...

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Veröffentlicht in:	Journal of applied toxicology 2023-10, Vol.43 (10), p.1421-1435
Hauptverfasser:	Tan, Huixin, Wang, Fenghe, Hu, Jiahuan, Duan, Xiaoyan, Bai, Wanting, Wang, Xinbo, Wang, Baolian, Su, Yan, Hu, Jinping
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic compounds Biochanin A Cations Cisplatin Creatinine Cytotoxicity Drug interaction Drug interactions Flavonoids Hydrogen bonds Inhibitors Injury prevention Kidneys Natural products Oct-2 protein Organic cation transporter Toxicity Urea
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