Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older
A high-compliance dietary intervention was conducted for 2 weeks in adults aged 50 years and older to investigate the preventing aging effects of a polyphenol-probiotic-enhanced diet (P-diet) by using inflammatory biological age (IBA). Following the P-diet, levels of interleukin-6 (IL-6), IL-10, and...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2023-04, Vol.71 (16), p.6314-6325 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Meng, Ning Zhou, Yang Zhang, Qinren Yu, Xiaohan Li, He Liu, Yanxiang Liu, Ming Li, Quanyang |
| description | A high-compliance dietary intervention was conducted for 2 weeks in adults aged 50 years and older to investigate the preventing aging effects of a polyphenol-probiotic-enhanced diet (P-diet) by using inflammatory biological age (IBA). Following the P-diet, levels of interleukin-6 (IL-6), IL-10, and C-reactive protein were reduced. These effects were accompanied by a significant increase in the richness of Lactobacillus and Bifidobacterium and decrease in CAG_56, as well as an increase in butyrate and acetate and decrease in lysine, uracil, and valine. We optimized a model by a back propagation artificial neural network to evaluate the degree of aging, with an R 2 of 0.68. After the P-diet intervention, IBA was younger than chronological age and the inflammatory aging potential (Δage) was observably reduced by 90.12%, with change in Δage having a direct negative association with Akkermansia. Overall, P-diet may alleviate chronic low-grade inflammation and thus prevent the procession of inflammatory aging. |
| doi_str_mv | 10.1021/acs.jafc.2c07241 |
| format | Article |
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Following the P-diet, levels of interleukin-6 (IL-6), IL-10, and C-reactive protein were reduced. These effects were accompanied by a significant increase in the richness of Lactobacillus and Bifidobacterium and decrease in CAG_56, as well as an increase in butyrate and acetate and decrease in lysine, uracil, and valine. We optimized a model by a back propagation artificial neural network to evaluate the degree of aging, with an R 2 of 0.68. After the P-diet intervention, IBA was younger than chronological age and the inflammatory aging potential (Δage) was observably reduced by 90.12%, with change in Δage having a direct negative association with Akkermansia. 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Agric. Food Chem</addtitle><description>A high-compliance dietary intervention was conducted for 2 weeks in adults aged 50 years and older to investigate the preventing aging effects of a polyphenol-probiotic-enhanced diet (P-diet) by using inflammatory biological age (IBA). Following the P-diet, levels of interleukin-6 (IL-6), IL-10, and C-reactive protein were reduced. These effects were accompanied by a significant increase in the richness of Lactobacillus and Bifidobacterium and decrease in CAG_56, as well as an increase in butyrate and acetate and decrease in lysine, uracil, and valine. We optimized a model by a back propagation artificial neural network to evaluate the degree of aging, with an R 2 of 0.68. After the P-diet intervention, IBA was younger than chronological age and the inflammatory aging potential (Δage) was observably reduced by 90.12%, with change in Δage having a direct negative association with Akkermansia. Overall, P-diet may alleviate chronic low-grade inflammation and thus prevent the procession of inflammatory aging.</description><subject>Aged</subject><subject>Aging</subject><subject>Bioactive Constituents, Metabolites, and Functions</subject><subject>Diet</subject><subject>Gastrointestinal Microbiome</subject><subject>Humans</subject><subject>Inflammation - prevention & control</subject><subject>Middle Aged</subject><subject>Polyphenols - pharmacology</subject><subject>Probiotics</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kbFu2zAQhomiReMm3TsVHDtULkmJpjS6idsGCBAPydBJOJFHWwFFuiQVIC_TZ60Uu9my8ADi-__D4SPkE2dLzgT_BjotH8DqpdBMiYq_IQsuBSsk5_VbsmATU9Ryxc_Ih5QeGGO1VOw9OSsVk6oumwX5e596v6PX3joYBsghPtHvfXBh12twdL1Dehfo5hHcCBlp3iPdRnxEn-fYeje_G2tRZxosBboN7umwRx9csY2h60PudbHxe_AaDb3qMcO0YQs5Y_S093RtRpfTvMhQyehvhJgoeENvncF4Qd5ZcAk_nuY5uf-xubv8Vdzc_ry-XN8UUJarXNRd2ZiqEY3tlFgJ1JVSeiUrYWXJtdHGQleb6UcIbpTWgFJ0FTZKCFbqmpfn5Mux9xDDnxFTboc-aXQOPIYxtaJmvFFKyBllR1THkFJE2x5iP0xXtZy1s5V2stLOVtqTlSny-dQ-dgOal8B_DRPw9Qg8R8MY_XTs633_ALtlmcM</recordid><startdate>20230426</startdate><enddate>20230426</enddate><creator>Meng, Ning</creator><creator>Zhou, Yang</creator><creator>Zhang, Qinren</creator><creator>Yu, Xiaohan</creator><creator>Li, He</creator><creator>Liu, Yanxiang</creator><creator>Liu, Ming</creator><creator>Li, Quanyang</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2116-076X</orcidid></search><sort><creationdate>20230426</creationdate><title>Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older</title><author>Meng, Ning ; Zhou, Yang ; Zhang, Qinren ; Yu, Xiaohan ; Li, He ; Liu, Yanxiang ; Liu, Ming ; Li, Quanyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a336t-8b39d4929fb7262ec477c6542f531cdcdfab8dc65221d7ccae52b4e972203c813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Bioactive Constituents, Metabolites, and Functions</topic><topic>Diet</topic><topic>Gastrointestinal Microbiome</topic><topic>Humans</topic><topic>Inflammation - prevention & control</topic><topic>Middle Aged</topic><topic>Polyphenols - pharmacology</topic><topic>Probiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meng, Ning</creatorcontrib><creatorcontrib>Zhou, Yang</creatorcontrib><creatorcontrib>Zhang, Qinren</creatorcontrib><creatorcontrib>Yu, Xiaohan</creatorcontrib><creatorcontrib>Li, He</creatorcontrib><creatorcontrib>Liu, Yanxiang</creatorcontrib><creatorcontrib>Liu, Ming</creatorcontrib><creatorcontrib>Li, Quanyang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Ning</au><au>Zhou, Yang</au><au>Zhang, Qinren</au><au>Yu, Xiaohan</au><au>Li, He</au><au>Liu, Yanxiang</au><au>Liu, Ming</au><au>Li, Quanyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2023-04-26</date><risdate>2023</risdate><volume>71</volume><issue>16</issue><spage>6314</spage><epage>6325</epage><pages>6314-6325</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>A high-compliance dietary intervention was conducted for 2 weeks in adults aged 50 years and older to investigate the preventing aging effects of a polyphenol-probiotic-enhanced diet (P-diet) by using inflammatory biological age (IBA). Following the P-diet, levels of interleukin-6 (IL-6), IL-10, and C-reactive protein were reduced. These effects were accompanied by a significant increase in the richness of Lactobacillus and Bifidobacterium and decrease in CAG_56, as well as an increase in butyrate and acetate and decrease in lysine, uracil, and valine. We optimized a model by a back propagation artificial neural network to evaluate the degree of aging, with an R 2 of 0.68. 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| subjects | Aged Aging Bioactive Constituents, Metabolites, and Functions Diet Gastrointestinal Microbiome Humans Inflammation - prevention & control Middle Aged Polyphenols - pharmacology Probiotics |
| title | Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older |
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