Visual Multifunctional Aggregation‐Induced Emission‐Based Bacterial Cellulose for Killing of Multidrug‐Resistant Bacteria
Multidrug‐resistant (MDR) bacteria‐related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation‐induced emission (AIE) molecule BITT‐composite...
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| Veröffentlicht in: | Advanced healthcare materials 2023-08, Vol.12 (21), p.e2300045-n/a |
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| creator | Shen, Zipeng Zhu, Wei Huang, Yajia Zhang, Jiangjiang Wu, Yifan Pan, Yinzhen Yang, Guang Wang, Dong Li, Ying Tang, Ben Zhong |
| description | Multidrug‐resistant (MDR) bacteria‐related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation‐induced emission (AIE) molecule BITT‐composited bacterial cellulose (BC) is presented as wound dressings. BC‐BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC‐BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC‐BITT composites show excellent wound healing performance in a mouse full‐thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.
A wound dressing with photodynamic and photothermal synergistic antibacterial effects shows excellent wound healing performance in a mouse full‐thickness skin wound model infected by multidrug resistant bacteria with negligible toxicity. |
| doi_str_mv | 10.1002/adhm.202300045 |
| format | Article |
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A wound dressing with photodynamic and photothermal synergistic antibacterial effects shows excellent wound healing performance in a mouse full‐thickness skin wound model infected by multidrug resistant bacteria with negligible toxicity.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202300045</identifier><identifier>PMID: 37042250</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>aggregation‐induced emission ; Antibacterial activity ; Antiinfectives and antibacterials ; Bacteria ; bacterial cellulose ; Biocompatibility ; Cellulose ; Composite materials ; Drug resistance ; Emission ; Medical dressings ; Multidrug resistant organisms ; photodynamic/photothermal therapy ; Toxicity ; wound dressings ; Wound healing ; Wound infection</subject><ispartof>Advanced healthcare materials, 2023-08, Vol.12 (21), p.e2300045-n/a</ispartof><rights>2023 Wiley‐VCH GmbH</rights><rights>2023 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3735-a068d8404c221aa9edd86d410a9695e13c790861d84e53118af64a04558456833</citedby><cites>FETCH-LOGICAL-c3735-a068d8404c221aa9edd86d410a9695e13c790861d84e53118af64a04558456833</cites><orcidid>0000-0002-0293-964X ; 0000-0002-9595-6296</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202300045$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202300045$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37042250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Zipeng</creatorcontrib><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Huang, Yajia</creatorcontrib><creatorcontrib>Zhang, Jiangjiang</creatorcontrib><creatorcontrib>Wu, Yifan</creatorcontrib><creatorcontrib>Pan, Yinzhen</creatorcontrib><creatorcontrib>Yang, Guang</creatorcontrib><creatorcontrib>Wang, Dong</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Tang, Ben Zhong</creatorcontrib><title>Visual Multifunctional Aggregation‐Induced Emission‐Based Bacterial Cellulose for Killing of Multidrug‐Resistant Bacteria</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Multidrug‐resistant (MDR) bacteria‐related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation‐induced emission (AIE) molecule BITT‐composited bacterial cellulose (BC) is presented as wound dressings. BC‐BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC‐BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC‐BITT composites show excellent wound healing performance in a mouse full‐thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.
A wound dressing with photodynamic and photothermal synergistic antibacterial effects shows excellent wound healing performance in a mouse full‐thickness skin wound model infected by multidrug resistant bacteria with negligible toxicity.</description><subject>aggregation‐induced emission</subject><subject>Antibacterial activity</subject><subject>Antiinfectives and antibacterials</subject><subject>Bacteria</subject><subject>bacterial cellulose</subject><subject>Biocompatibility</subject><subject>Cellulose</subject><subject>Composite materials</subject><subject>Drug resistance</subject><subject>Emission</subject><subject>Medical dressings</subject><subject>Multidrug resistant organisms</subject><subject>photodynamic/photothermal therapy</subject><subject>Toxicity</subject><subject>wound dressings</subject><subject>Wound healing</subject><subject>Wound infection</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkctOGzEUhi1URBCw7RKNxKabpMfXsZch5aYSVarabkdm7BkcOTPBHqtiRR-hz8iT1NHQILFhdS76_l_2-RH6iGGGAchnbe7XMwKEAgDje-iQYEWmRHD1YdczmKCTGFcZAcGxkPgATWgJjBAOh-jpl4tJ-2KZ_OCa1NWD67s8z9s22FZvp-c_f286k2priou1i3FcneuYF-e6HmxwWbCw3iffR1s0fSi-Ou9d1xZ9MzqbkNos-m6ji4Puhp3wGO032kd78lKP0M_Lix-L6-ntt6ubxfx2WtOS8qkGIY1kwGpCsNbKGiOFYRi0EopbTOtSgRQ4M5ZTjKVuBNP5KFwyLiSlR-jT6LsJ_UOycajyV-r8Zt3ZPsWKSADMSolVRs_eoKs-hXyULcWpKkvgIlOzkapDH2OwTbUJbq3DY4Wh2qZTbdOpdulkwemLbbpbW7PD_2eRATUCv523j-_YVfMv18tX83-soZ4W</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Shen, Zipeng</creator><creator>Zhu, Wei</creator><creator>Huang, Yajia</creator><creator>Zhang, Jiangjiang</creator><creator>Wu, Yifan</creator><creator>Pan, Yinzhen</creator><creator>Yang, Guang</creator><creator>Wang, Dong</creator><creator>Li, Ying</creator><creator>Tang, Ben Zhong</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0293-964X</orcidid><orcidid>https://orcid.org/0000-0002-9595-6296</orcidid></search><sort><creationdate>20230801</creationdate><title>Visual Multifunctional Aggregation‐Induced Emission‐Based Bacterial Cellulose for Killing of Multidrug‐Resistant Bacteria</title><author>Shen, Zipeng ; Zhu, Wei ; Huang, Yajia ; Zhang, Jiangjiang ; Wu, Yifan ; Pan, Yinzhen ; Yang, Guang ; Wang, Dong ; Li, Ying ; Tang, Ben Zhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3735-a068d8404c221aa9edd86d410a9695e13c790861d84e53118af64a04558456833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>aggregation‐induced emission</topic><topic>Antibacterial activity</topic><topic>Antiinfectives and antibacterials</topic><topic>Bacteria</topic><topic>bacterial cellulose</topic><topic>Biocompatibility</topic><topic>Cellulose</topic><topic>Composite materials</topic><topic>Drug resistance</topic><topic>Emission</topic><topic>Medical dressings</topic><topic>Multidrug resistant organisms</topic><topic>photodynamic/photothermal therapy</topic><topic>Toxicity</topic><topic>wound dressings</topic><topic>Wound healing</topic><topic>Wound infection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Zipeng</creatorcontrib><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Huang, Yajia</creatorcontrib><creatorcontrib>Zhang, Jiangjiang</creatorcontrib><creatorcontrib>Wu, Yifan</creatorcontrib><creatorcontrib>Pan, Yinzhen</creatorcontrib><creatorcontrib>Yang, Guang</creatorcontrib><creatorcontrib>Wang, Dong</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Tang, Ben Zhong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Zipeng</au><au>Zhu, Wei</au><au>Huang, Yajia</au><au>Zhang, Jiangjiang</au><au>Wu, Yifan</au><au>Pan, Yinzhen</au><au>Yang, Guang</au><au>Wang, Dong</au><au>Li, Ying</au><au>Tang, Ben Zhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual Multifunctional Aggregation‐Induced Emission‐Based Bacterial Cellulose for Killing of Multidrug‐Resistant Bacteria</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>12</volume><issue>21</issue><spage>e2300045</spage><epage>n/a</epage><pages>e2300045-n/a</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>Multidrug‐resistant (MDR) bacteria‐related wound infections are a thorny issue. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, an aggregation‐induced emission (AIE) molecule BITT‐composited bacterial cellulose (BC) is presented as wound dressings. BC‐BITT composites have good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC‐BITT composites retain the advantages of biocompatible BC, and display photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC‐BITT composites show excellent wound healing performance in a mouse full‐thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. This work paves a way for treating clinically troublesome wound infections.
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | aggregation‐induced emission Antibacterial activity Antiinfectives and antibacterials Bacteria bacterial cellulose Biocompatibility Cellulose Composite materials Drug resistance Emission Medical dressings Multidrug resistant organisms photodynamic/photothermal therapy Toxicity wound dressings Wound healing Wound infection |
| title | Visual Multifunctional Aggregation‐Induced Emission‐Based Bacterial Cellulose for Killing of Multidrug‐Resistant Bacteria |
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