Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection
Background Cancer is increasingly recognized as a metabolic disease, with evidence suggesting that oxidative phosphorylation (OXPHOS) plays a significant role in the progression of numerous cancer cells. OXPHOS not only provides sufficient energy for tumor tissue survival but also regulates conditio...
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| Veröffentlicht in: | Cellular oncology (Dordrecht) 2023-08, Vol.46 (4), p.847-865 |
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| creator | Qiu, Xutong Li, Yi Zhang, Zhuoyuan |
| description | Background
Cancer is increasingly recognized as a metabolic disease, with evidence suggesting that oxidative phosphorylation (OXPHOS) plays a significant role in the progression of numerous cancer cells. OXPHOS not only provides sufficient energy for tumor tissue survival but also regulates conditions for tumor proliferation, invasion, and metastasis. Alterations in OXPHOS can also impair the immune function of immune cells in the tumor microenvironment, leading to immune evasion. Therefore, investigating the relationship between OXPHOS and immune escape is crucial in cancer-related research. This review aims to summarize the effects of transcriptional, mitochondrial genetic, metabolic regulation, and mitochondrial dynamics on OXPHOS in different cancers. Additionally, it highlights the role of OXPHOS in immune escape by affecting various immune cells. Finally, it concludes with an overview of recent advances in antitumor strategies targeting both immune and metabolic processes and proposes promising therapeutic targets by analyzing the limitations of current targeted drugs.
Conclusions
The metabolic shift towards OXPHOS contributes significantly to tumor proliferation, progression, metastasis, immune escape, and poor prognosis. A thorough investigation of concrete mechanisms of OXPHOS regulation in different types of tumors and the combination usage of OXPHOS-targeted drugs with existing immunotherapies could potentially uncover new therapeutic targets for future antitumor therapies. |
| doi_str_mv | 10.1007/s13402-023-00801-0 |
| format | Article |
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Cancer is increasingly recognized as a metabolic disease, with evidence suggesting that oxidative phosphorylation (OXPHOS) plays a significant role in the progression of numerous cancer cells. OXPHOS not only provides sufficient energy for tumor tissue survival but also regulates conditions for tumor proliferation, invasion, and metastasis. Alterations in OXPHOS can also impair the immune function of immune cells in the tumor microenvironment, leading to immune evasion. Therefore, investigating the relationship between OXPHOS and immune escape is crucial in cancer-related research. This review aims to summarize the effects of transcriptional, mitochondrial genetic, metabolic regulation, and mitochondrial dynamics on OXPHOS in different cancers. Additionally, it highlights the role of OXPHOS in immune escape by affecting various immune cells. Finally, it concludes with an overview of recent advances in antitumor strategies targeting both immune and metabolic processes and proposes promising therapeutic targets by analyzing the limitations of current targeted drugs.
Conclusions
The metabolic shift towards OXPHOS contributes significantly to tumor proliferation, progression, metastasis, immune escape, and poor prognosis. A thorough investigation of concrete mechanisms of OXPHOS regulation in different types of tumors and the combination usage of OXPHOS-targeted drugs with existing immunotherapies could potentially uncover new therapeutic targets for future antitumor therapies.</description><identifier>ISSN: 2211-3428</identifier><identifier>ISSN: 2211-3436</identifier><identifier>EISSN: 2211-3436</identifier><identifier>DOI: 10.1007/s13402-023-00801-0</identifier><identifier>PMID: 37040057</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Antitumor agents ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer Research ; Drug development ; Humans ; Immune evasion ; Immune response ; Immunosuppressive agents ; Immunotherapy ; Medical prognosis ; Metabolic disorders ; Metabolism ; Metastases ; Metastasis ; Mitochondria - metabolism ; Neoplasms - genetics ; Oncology ; Oxidative Phosphorylation ; Pathology ; Phosphorylation ; Review ; Therapeutic applications ; Therapeutic targets ; Tumor Microenvironment ; Tumors</subject><ispartof>Cellular oncology (Dordrecht), 2023-08, Vol.46 (4), p.847-865</ispartof><rights>Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Springer Nature Switzerland AG.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-31bd526442fd727ca3e522ff003afcfa8cb437a01b992437eb99cf1ee5012d943</citedby><cites>FETCH-LOGICAL-c375t-31bd526442fd727ca3e522ff003afcfa8cb437a01b992437eb99cf1ee5012d943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13402-023-00801-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13402-023-00801-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37040057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Xutong</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Zhang, Zhuoyuan</creatorcontrib><title>Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection</title><title>Cellular oncology (Dordrecht)</title><addtitle>Cell Oncol</addtitle><addtitle>Cell Oncol (Dordr)</addtitle><description>Background
Cancer is increasingly recognized as a metabolic disease, with evidence suggesting that oxidative phosphorylation (OXPHOS) plays a significant role in the progression of numerous cancer cells. OXPHOS not only provides sufficient energy for tumor tissue survival but also regulates conditions for tumor proliferation, invasion, and metastasis. Alterations in OXPHOS can also impair the immune function of immune cells in the tumor microenvironment, leading to immune evasion. Therefore, investigating the relationship between OXPHOS and immune escape is crucial in cancer-related research. This review aims to summarize the effects of transcriptional, mitochondrial genetic, metabolic regulation, and mitochondrial dynamics on OXPHOS in different cancers. Additionally, it highlights the role of OXPHOS in immune escape by affecting various immune cells. Finally, it concludes with an overview of recent advances in antitumor strategies targeting both immune and metabolic processes and proposes promising therapeutic targets by analyzing the limitations of current targeted drugs.
Conclusions
The metabolic shift towards OXPHOS contributes significantly to tumor proliferation, progression, metastasis, immune escape, and poor prognosis. A thorough investigation of concrete mechanisms of OXPHOS regulation in different types of tumors and the combination usage of OXPHOS-targeted drugs with existing immunotherapies could potentially uncover new therapeutic targets for future antitumor therapies.</description><subject>Antitumor agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Drug development</subject><subject>Humans</subject><subject>Immune evasion</subject><subject>Immune response</subject><subject>Immunosuppressive agents</subject><subject>Immunotherapy</subject><subject>Medical prognosis</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mitochondria - metabolism</subject><subject>Neoplasms - genetics</subject><subject>Oncology</subject><subject>Oxidative Phosphorylation</subject><subject>Pathology</subject><subject>Phosphorylation</subject><subject>Review</subject><subject>Therapeutic applications</subject><subject>Therapeutic targets</subject><subject>Tumor Microenvironment</subject><subject>Tumors</subject><issn>2211-3428</issn><issn>2211-3436</issn><issn>2211-3436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFO3DAQhq2qqCDgBThUlnrhknZsJ3HSW7WiUAmJC5wtxxmz2SZ2sJ0uvH29LFCJQy2NZkb-5rc1PyFnDL4yAPktMlECL4CLAqABVsAHcsQ5Y4UoRf3xrebNITmNcQP5lDWrq_oTORQSSoBKHpHtKvgYkx5_0w7TFtFR_zj0Og1_kM5rH3OEpzH33lHtejpM0-KQYjR6Rjo4arQzGL5TTR1uqfG5mxP1lqY1hswsaTA06XCPKdKII5qd1gk5sHqMePqSj8ndz4vb1VVxfXP5a_XjujBCVqkQrOsrXpclt73k0miBFefWAghtjdWN6UohNbCubXmuMGdjGWIFjPdtKY7J-V53Dv5hwZjUNESD46gd-iUqLtu24Q2rIaNf3qEbvwSXf6d4I9qGVVLUmeJ7yuwWF9CqOQyTDk-Kgdo5o_bOqOyMenZG7aQ_v0gv3YT928irDxkQeyDmK3eP4d_b_5H9C64FmgA</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Qiu, Xutong</creator><creator>Li, Yi</creator><creator>Zhang, Zhuoyuan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230801</creationdate><title>Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection</title><author>Qiu, Xutong ; Li, Yi ; Zhang, Zhuoyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-31bd526442fd727ca3e522ff003afcfa8cb437a01b992437eb99cf1ee5012d943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antitumor agents</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Drug development</topic><topic>Humans</topic><topic>Immune evasion</topic><topic>Immune response</topic><topic>Immunosuppressive agents</topic><topic>Immunotherapy</topic><topic>Medical prognosis</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mitochondria - metabolism</topic><topic>Neoplasms - genetics</topic><topic>Oncology</topic><topic>Oxidative Phosphorylation</topic><topic>Pathology</topic><topic>Phosphorylation</topic><topic>Review</topic><topic>Therapeutic applications</topic><topic>Therapeutic targets</topic><topic>Tumor Microenvironment</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Xutong</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Zhang, Zhuoyuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular oncology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Xutong</au><au>Li, Yi</au><au>Zhang, Zhuoyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection</atitle><jtitle>Cellular oncology (Dordrecht)</jtitle><stitle>Cell Oncol</stitle><addtitle>Cell Oncol (Dordr)</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>46</volume><issue>4</issue><spage>847</spage><epage>865</epage><pages>847-865</pages><issn>2211-3428</issn><issn>2211-3436</issn><eissn>2211-3436</eissn><abstract>Background
Cancer is increasingly recognized as a metabolic disease, with evidence suggesting that oxidative phosphorylation (OXPHOS) plays a significant role in the progression of numerous cancer cells. OXPHOS not only provides sufficient energy for tumor tissue survival but also regulates conditions for tumor proliferation, invasion, and metastasis. Alterations in OXPHOS can also impair the immune function of immune cells in the tumor microenvironment, leading to immune evasion. Therefore, investigating the relationship between OXPHOS and immune escape is crucial in cancer-related research. This review aims to summarize the effects of transcriptional, mitochondrial genetic, metabolic regulation, and mitochondrial dynamics on OXPHOS in different cancers. Additionally, it highlights the role of OXPHOS in immune escape by affecting various immune cells. Finally, it concludes with an overview of recent advances in antitumor strategies targeting both immune and metabolic processes and proposes promising therapeutic targets by analyzing the limitations of current targeted drugs.
Conclusions
The metabolic shift towards OXPHOS contributes significantly to tumor proliferation, progression, metastasis, immune escape, and poor prognosis. A thorough investigation of concrete mechanisms of OXPHOS regulation in different types of tumors and the combination usage of OXPHOS-targeted drugs with existing immunotherapies could potentially uncover new therapeutic targets for future antitumor therapies.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>37040057</pmid><doi>10.1007/s13402-023-00801-0</doi><tpages>19</tpages></addata></record> |
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| subjects | Antitumor agents Biomedical and Life Sciences Biomedicine Cancer Cancer Research Drug development Humans Immune evasion Immune response Immunosuppressive agents Immunotherapy Medical prognosis Metabolic disorders Metabolism Metastases Metastasis Mitochondria - metabolism Neoplasms - genetics Oncology Oxidative Phosphorylation Pathology Phosphorylation Review Therapeutic applications Therapeutic targets Tumor Microenvironment Tumors |
| title | Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection |
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