Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study
Hemoporfin-mediated photodynamic therapy (HMME-PDT) is currently considered one of the most promising therapies for port-wine stain (PWS). However, the efficacy of this is very variable and needs further studies. A total of 101 patients with PWS in the face, neck, or extremities who received at leas...
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| Veröffentlicht in: | Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2023-09, Vol.39 (5), p.441-448 |
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| container_title | Photodermatology, photoimmunology & photomedicine |
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| creator | Chen, Jiajie Gui, Yu Wang, Sun Huang, Dawei Lyu, Jiajie Cheng, Hui Ding, Yantao Zhang, Huabing Liu, Shengxiu |
| description | Hemoporfin-mediated photodynamic therapy (HMME-PDT) is currently considered one of the most promising therapies for port-wine stain (PWS). However, the efficacy of this is very variable and needs further studies.
A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME-PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.
The efficacy of HMME-PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p |
| doi_str_mv | 10.1111/phpp.12874 |
| format | Article |
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A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME-PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.
The efficacy of HMME-PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p < .05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (p < .001). Ordinal logistic regression analysis confirmed the above-mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences.
Our studies demonstrated that HMME-PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin-PDT, while multiple HMME-PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.</description><identifier>ISSN: 0905-4383</identifier><identifier>ISSN: 1600-0781</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/phpp.12874</identifier><identifier>PMID: 37036012</identifier><language>eng</language><publisher>England</publisher><ispartof>Photodermatology, photoimmunology & photomedicine, 2023-09, Vol.39 (5), p.441-448</ispartof><rights>2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-dfb46e43bec9b47642edb7dadf82bc0ce23024162ef60b4d064c326c852291b53</citedby><cites>FETCH-LOGICAL-c287t-dfb46e43bec9b47642edb7dadf82bc0ce23024162ef60b4d064c326c852291b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37036012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jiajie</creatorcontrib><creatorcontrib>Gui, Yu</creatorcontrib><creatorcontrib>Wang, Sun</creatorcontrib><creatorcontrib>Huang, Dawei</creatorcontrib><creatorcontrib>Lyu, Jiajie</creatorcontrib><creatorcontrib>Cheng, Hui</creatorcontrib><creatorcontrib>Ding, Yantao</creatorcontrib><creatorcontrib>Zhang, Huabing</creatorcontrib><creatorcontrib>Liu, Shengxiu</creatorcontrib><title>Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study</title><title>Photodermatology, photoimmunology & photomedicine</title><addtitle>Photodermatol Photoimmunol Photomed</addtitle><description>Hemoporfin-mediated photodynamic therapy (HMME-PDT) is currently considered one of the most promising therapies for port-wine stain (PWS). However, the efficacy of this is very variable and needs further studies.
A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME-PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.
The efficacy of HMME-PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p < .05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (p < .001). Ordinal logistic regression analysis confirmed the above-mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences.
Our studies demonstrated that HMME-PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin-PDT, while multiple HMME-PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.</description><issn>0905-4383</issn><issn>1600-0781</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNo9kMtq3DAUQEVoaCbTbvIBRcsQcHL18Ku7IaRNYaCbZG1k6SqjYFuqpGnw39fOo9pcEIfDvYeQCwbXbHk34RDCNeNNLU_IhlUABdQN-0Q20EJZSNGIM3Ke0jMASAnsMzkTNYgKGN-QeTepYU4uUW9pxEFlNNQqnX1MVFmLOrvpiR5w9MFH66ZiRONeqXDw2Zt5UqPTNB8wqjBT6yNdwFy8uAlpyspN3-luMefoU1htf9fvo5m_kFOrhoRf3-eWPP64e7i9L_a_f_663e0LvVyUC2N7WaEUPeq2l3UlOZq-NsrYhvcaNHIBXLKKo62glwYqqQWvdFNy3rK-FFty-eYN0f85Ysrd6JLGYVAT-mPqeN22rC5LvqJXb6helk0RbReiG1WcOwbdmrpbU3evqRf427v32C9N_qMfbcU_M-h88g</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Chen, Jiajie</creator><creator>Gui, Yu</creator><creator>Wang, Sun</creator><creator>Huang, Dawei</creator><creator>Lyu, Jiajie</creator><creator>Cheng, Hui</creator><creator>Ding, Yantao</creator><creator>Zhang, Huabing</creator><creator>Liu, Shengxiu</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230901</creationdate><title>Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study</title><author>Chen, Jiajie ; Gui, Yu ; Wang, Sun ; Huang, Dawei ; Lyu, Jiajie ; Cheng, Hui ; Ding, Yantao ; Zhang, Huabing ; Liu, Shengxiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-dfb46e43bec9b47642edb7dadf82bc0ce23024162ef60b4d064c326c852291b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jiajie</creatorcontrib><creatorcontrib>Gui, Yu</creatorcontrib><creatorcontrib>Wang, Sun</creatorcontrib><creatorcontrib>Huang, Dawei</creatorcontrib><creatorcontrib>Lyu, Jiajie</creatorcontrib><creatorcontrib>Cheng, Hui</creatorcontrib><creatorcontrib>Ding, Yantao</creatorcontrib><creatorcontrib>Zhang, Huabing</creatorcontrib><creatorcontrib>Liu, Shengxiu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jiajie</au><au>Gui, Yu</au><au>Wang, Sun</au><au>Huang, Dawei</au><au>Lyu, Jiajie</au><au>Cheng, Hui</au><au>Ding, Yantao</au><au>Zhang, Huabing</au><au>Liu, Shengxiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study</atitle><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>39</volume><issue>5</issue><spage>441</spage><epage>448</epage><pages>441-448</pages><issn>0905-4383</issn><issn>1600-0781</issn><eissn>1600-0781</eissn><abstract>Hemoporfin-mediated photodynamic therapy (HMME-PDT) is currently considered one of the most promising therapies for port-wine stain (PWS). However, the efficacy of this is very variable and needs further studies.
A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME-PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.
The efficacy of HMME-PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p < .05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (p < .001). Ordinal logistic regression analysis confirmed the above-mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences.
Our studies demonstrated that HMME-PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin-PDT, while multiple HMME-PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.</abstract><cop>England</cop><pmid>37036012</pmid><doi>10.1111/phpp.12874</doi><tpages>8</tpages></addata></record> |
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| title | Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study |
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