Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms
Accidents involving snakes from Bothrops spp. and Crotalus spp. constitute the most important cause of envenomation in Brazil and Argentina. Musa spp. (banana) have been reported to be used in popular medicine against snakebite by the members of the Canudos Settlement, located in Goiás. In this way,...
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| Veröffentlicht in: | Toxicon (Oxford) 2023-06, Vol.228, p.107106-107106, Article 107106 |
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| creator | Matos da Silva, Márcia Pereira Alexandre, Gerso Magalhães, Marta Regina Torres, Ana Maria Kato, Lucilia Costa da Silva, Victória Teixeira de Saboia Morais, Simone Maria Garcia Rodriguez, Armando Pacheco Fill, Taícia Pereira, Alana Kelyene Roque, Jussara Souza Simão, Jorge Luiz Pasqualotto Severino, Vanessa Gisele |
| description | Accidents involving snakes from Bothrops spp. and Crotalus spp. constitute the most important cause of envenomation in Brazil and Argentina. Musa spp. (banana) have been reported to be used in popular medicine against snakebite by the members of the Canudos Settlement, located in Goiás. In this way, the aim of this work was to evaluate the antivenom effect of the Ouro (AA), Prata (AAB), Prata-anã (AAB) and Figo (ABB) cultivars against in vitro (phospholipase, coagulation and proteolytic) and in vivo (lethality and toxicity) activities caused by the venoms and toxicity (Artemia salina nauplii and Danio rerio embryos) of Musa spp. as well as the annotation of chemical compounds possibly related to these activities. From the in vitro antiophidic tests with the sap, we observed 100% inhibition of the phospholipase and coagulant activities with the cultivars Prata-anã and Figo against the venoms of B. alternatus and C. d. collineatus, B. diporus and B. pauloensis, respectively, and neutralisation of the lethality against the B. diporus venom. It was observed that the cultivars of Musa spp. did not show toxicity against Artemia salina nauplii and Danio rerio embryos. The sap analysis via HPLC-MS/MS allowed the annotation of the 13 compounds: abscisic acid, shikimic acid, citric acid, quinic acid, afzelechin, Glp-hexose, glucose, sucrose, isorhamnetin-3-O-galactoside-6-raminoside, kaempferol-3-glucoside-3-raminoside, myricetin-3-O-rutinoside, procyanidin B1 and rutin. Therefore, it can be seen that Musa spp. is a potential therapeutic agent that can act to neutralise the effects caused by snakebites.
[Display omitted]
•Coagulant, phospholipase, proteolytic and lethal activities were reduced by Musa spp. cultivars.•Cultivars saps were studied by UHPLC-Q-Orbitrap MS/MS and molecular networking analysis.•The saps are rich in organooxygen compounds, prenol lipid, carboxylic acid and flavonoids.•Musa spp. cultivars do not show toxicity against Artemia salina nauplii and Danio rerio embryos.•Musa spp. cultivars are a strategy against envenomation by Bothrops and Crotalus genus. |
| doi_str_mv | 10.1016/j.toxicon.2023.107106 |
| format | Article |
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[Display omitted]
•Coagulant, phospholipase, proteolytic and lethal activities were reduced by Musa spp. cultivars.•Cultivars saps were studied by UHPLC-Q-Orbitrap MS/MS and molecular networking analysis.•The saps are rich in organooxygen compounds, prenol lipid, carboxylic acid and flavonoids.•Musa spp. cultivars do not show toxicity against Artemia salina nauplii and Danio rerio embryos.•Musa spp. cultivars are a strategy against envenomation by Bothrops and Crotalus genus.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/j.toxicon.2023.107106</identifier><identifier>PMID: 37031872</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antivenins - pharmacology ; Antivenins - therapeutic use ; Antivenom ; Banana ; Bothrops ; Crotalid Venoms - chemistry ; Crotalid Venoms - toxicity ; Crotalus ; Musa ; Musa spp ; Phospholipases ; Sap ; Snake Bites - drug therapy ; Snake Venoms ; Tandem Mass Spectrometry ; Zebrafish</subject><ispartof>Toxicon (Oxford), 2023-06, Vol.228, p.107106-107106, Article 107106</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-50fc19d9fffc7437e1085e7e82acdd1e109b4ce8a9aa94196465bfdd3966cffa3</citedby><cites>FETCH-LOGICAL-c365t-50fc19d9fffc7437e1085e7e82acdd1e109b4ce8a9aa94196465bfdd3966cffa3</cites><orcidid>0000-0001-5384-6657</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxicon.2023.107106$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37031872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matos da Silva, Márcia</creatorcontrib><creatorcontrib>Pereira Alexandre, Gerso</creatorcontrib><creatorcontrib>Magalhães, Marta Regina</creatorcontrib><creatorcontrib>Torres, Ana Maria</creatorcontrib><creatorcontrib>Kato, Lucilia</creatorcontrib><creatorcontrib>Costa da Silva, Victória</creatorcontrib><creatorcontrib>Teixeira de Saboia Morais, Simone Maria</creatorcontrib><creatorcontrib>Garcia Rodriguez, Armando</creatorcontrib><creatorcontrib>Pacheco Fill, Taícia</creatorcontrib><creatorcontrib>Pereira, Alana Kelyene</creatorcontrib><creatorcontrib>Roque, Jussara</creatorcontrib><creatorcontrib>Souza Simão, Jorge Luiz</creatorcontrib><creatorcontrib>Pasqualotto Severino, Vanessa Gisele</creatorcontrib><title>Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Accidents involving snakes from Bothrops spp. and Crotalus spp. constitute the most important cause of envenomation in Brazil and Argentina. Musa spp. (banana) have been reported to be used in popular medicine against snakebite by the members of the Canudos Settlement, located in Goiás. In this way, the aim of this work was to evaluate the antivenom effect of the Ouro (AA), Prata (AAB), Prata-anã (AAB) and Figo (ABB) cultivars against in vitro (phospholipase, coagulation and proteolytic) and in vivo (lethality and toxicity) activities caused by the venoms and toxicity (Artemia salina nauplii and Danio rerio embryos) of Musa spp. as well as the annotation of chemical compounds possibly related to these activities. From the in vitro antiophidic tests with the sap, we observed 100% inhibition of the phospholipase and coagulant activities with the cultivars Prata-anã and Figo against the venoms of B. alternatus and C. d. collineatus, B. diporus and B. pauloensis, respectively, and neutralisation of the lethality against the B. diporus venom. It was observed that the cultivars of Musa spp. did not show toxicity against Artemia salina nauplii and Danio rerio embryos. The sap analysis via HPLC-MS/MS allowed the annotation of the 13 compounds: abscisic acid, shikimic acid, citric acid, quinic acid, afzelechin, Glp-hexose, glucose, sucrose, isorhamnetin-3-O-galactoside-6-raminoside, kaempferol-3-glucoside-3-raminoside, myricetin-3-O-rutinoside, procyanidin B1 and rutin. Therefore, it can be seen that Musa spp. is a potential therapeutic agent that can act to neutralise the effects caused by snakebites.
[Display omitted]
•Coagulant, phospholipase, proteolytic and lethal activities were reduced by Musa spp. cultivars.•Cultivars saps were studied by UHPLC-Q-Orbitrap MS/MS and molecular networking analysis.•The saps are rich in organooxygen compounds, prenol lipid, carboxylic acid and flavonoids.•Musa spp. cultivars do not show toxicity against Artemia salina nauplii and Danio rerio embryos.•Musa spp. cultivars are a strategy against envenomation by Bothrops and Crotalus genus.</description><subject>Animals</subject><subject>Antivenins - pharmacology</subject><subject>Antivenins - therapeutic use</subject><subject>Antivenom</subject><subject>Banana</subject><subject>Bothrops</subject><subject>Crotalid Venoms - chemistry</subject><subject>Crotalid Venoms - toxicity</subject><subject>Crotalus</subject><subject>Musa</subject><subject>Musa spp</subject><subject>Phospholipases</subject><subject>Sap</subject><subject>Snake Bites - drug therapy</subject><subject>Snake Venoms</subject><subject>Tandem Mass Spectrometry</subject><subject>Zebrafish</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1vFCEUhonR2G31J9Rw6c1sYZgvroxu-pXUeKPXhIXDlnUGRg6zsf9e2l29NSGQQ56XNzyEXHK25ox3V_t1jr-9iWFds1qUu56z7hVZ8aGXleAte01WjDW8YgU_I-eIe8aYGGT3lpyJnokC1ity-LqgpjjPa2qWMfuDTkh1WTTAkpMePfqwoxiXZIDqnfYBcxknoC_9VJsS8tkD0ujol5gfU5xLPli6STHrcUG6g1B2DPon0AOEOOE78sbpEeH96bwgP26uv2_uqodvt_ebzw-VEV2bq5Y5w6WVzjnTN6IHzoYWehhqbazlZZTbxsCgpday4bJrunbrrBWy64xzWlyQj8d35xR_LYBZTR4NjKMOEBdUdS8l7-umaQvaHlGTImICp-bkJ52eFGfqWbnaq5Ny9axcHZWX3IdTxbKdwP5L_XVcgE9HAMpHDx6SQuMhGLA-gcnKRv-fij8xEJfz</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Matos da Silva, Márcia</creator><creator>Pereira Alexandre, Gerso</creator><creator>Magalhães, Marta Regina</creator><creator>Torres, Ana Maria</creator><creator>Kato, Lucilia</creator><creator>Costa da Silva, Victória</creator><creator>Teixeira de Saboia Morais, Simone Maria</creator><creator>Garcia Rodriguez, Armando</creator><creator>Pacheco Fill, Taícia</creator><creator>Pereira, Alana Kelyene</creator><creator>Roque, Jussara</creator><creator>Souza Simão, Jorge Luiz</creator><creator>Pasqualotto Severino, Vanessa Gisele</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5384-6657</orcidid></search><sort><creationdate>20230601</creationdate><title>Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms</title><author>Matos da Silva, Márcia ; Pereira Alexandre, Gerso ; Magalhães, Marta Regina ; Torres, Ana Maria ; Kato, Lucilia ; Costa da Silva, Victória ; Teixeira de Saboia Morais, Simone Maria ; Garcia Rodriguez, Armando ; Pacheco Fill, Taícia ; Pereira, Alana Kelyene ; Roque, Jussara ; Souza Simão, Jorge Luiz ; Pasqualotto Severino, Vanessa Gisele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-50fc19d9fffc7437e1085e7e82acdd1e109b4ce8a9aa94196465bfdd3966cffa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Antivenins - pharmacology</topic><topic>Antivenins - therapeutic use</topic><topic>Antivenom</topic><topic>Banana</topic><topic>Bothrops</topic><topic>Crotalid Venoms - chemistry</topic><topic>Crotalid Venoms - toxicity</topic><topic>Crotalus</topic><topic>Musa</topic><topic>Musa spp</topic><topic>Phospholipases</topic><topic>Sap</topic><topic>Snake Bites - drug therapy</topic><topic>Snake Venoms</topic><topic>Tandem Mass Spectrometry</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matos da Silva, Márcia</creatorcontrib><creatorcontrib>Pereira Alexandre, Gerso</creatorcontrib><creatorcontrib>Magalhães, Marta Regina</creatorcontrib><creatorcontrib>Torres, Ana Maria</creatorcontrib><creatorcontrib>Kato, Lucilia</creatorcontrib><creatorcontrib>Costa da Silva, Victória</creatorcontrib><creatorcontrib>Teixeira de Saboia Morais, Simone Maria</creatorcontrib><creatorcontrib>Garcia Rodriguez, Armando</creatorcontrib><creatorcontrib>Pacheco Fill, Taícia</creatorcontrib><creatorcontrib>Pereira, Alana Kelyene</creatorcontrib><creatorcontrib>Roque, Jussara</creatorcontrib><creatorcontrib>Souza Simão, Jorge Luiz</creatorcontrib><creatorcontrib>Pasqualotto Severino, Vanessa Gisele</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matos da Silva, Márcia</au><au>Pereira Alexandre, Gerso</au><au>Magalhães, Marta Regina</au><au>Torres, Ana Maria</au><au>Kato, Lucilia</au><au>Costa da Silva, Victória</au><au>Teixeira de Saboia Morais, Simone Maria</au><au>Garcia Rodriguez, Armando</au><au>Pacheco Fill, Taícia</au><au>Pereira, Alana Kelyene</au><au>Roque, Jussara</au><au>Souza Simão, Jorge Luiz</au><au>Pasqualotto Severino, Vanessa Gisele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>228</volume><spage>107106</spage><epage>107106</epage><pages>107106-107106</pages><artnum>107106</artnum><issn>0041-0101</issn><eissn>1879-3150</eissn><abstract>Accidents involving snakes from Bothrops spp. and Crotalus spp. constitute the most important cause of envenomation in Brazil and Argentina. Musa spp. (banana) have been reported to be used in popular medicine against snakebite by the members of the Canudos Settlement, located in Goiás. In this way, the aim of this work was to evaluate the antivenom effect of the Ouro (AA), Prata (AAB), Prata-anã (AAB) and Figo (ABB) cultivars against in vitro (phospholipase, coagulation and proteolytic) and in vivo (lethality and toxicity) activities caused by the venoms and toxicity (Artemia salina nauplii and Danio rerio embryos) of Musa spp. as well as the annotation of chemical compounds possibly related to these activities. From the in vitro antiophidic tests with the sap, we observed 100% inhibition of the phospholipase and coagulant activities with the cultivars Prata-anã and Figo against the venoms of B. alternatus and C. d. collineatus, B. diporus and B. pauloensis, respectively, and neutralisation of the lethality against the B. diporus venom. It was observed that the cultivars of Musa spp. did not show toxicity against Artemia salina nauplii and Danio rerio embryos. The sap analysis via HPLC-MS/MS allowed the annotation of the 13 compounds: abscisic acid, shikimic acid, citric acid, quinic acid, afzelechin, Glp-hexose, glucose, sucrose, isorhamnetin-3-O-galactoside-6-raminoside, kaempferol-3-glucoside-3-raminoside, myricetin-3-O-rutinoside, procyanidin B1 and rutin. Therefore, it can be seen that Musa spp. is a potential therapeutic agent that can act to neutralise the effects caused by snakebites.
[Display omitted]
•Coagulant, phospholipase, proteolytic and lethal activities were reduced by Musa spp. cultivars.•Cultivars saps were studied by UHPLC-Q-Orbitrap MS/MS and molecular networking analysis.•The saps are rich in organooxygen compounds, prenol lipid, carboxylic acid and flavonoids.•Musa spp. cultivars do not show toxicity against Artemia salina nauplii and Danio rerio embryos.•Musa spp. cultivars are a strategy against envenomation by Bothrops and Crotalus genus.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37031872</pmid><doi>10.1016/j.toxicon.2023.107106</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5384-6657</orcidid></addata></record> |
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| ispartof | Toxicon (Oxford), 2023-06, Vol.228, p.107106-107106, Article 107106 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antivenins - pharmacology Antivenins - therapeutic use Antivenom Banana Bothrops Crotalid Venoms - chemistry Crotalid Venoms - toxicity Crotalus Musa Musa spp Phospholipases Sap Snake Bites - drug therapy Snake Venoms Tandem Mass Spectrometry Zebrafish |
| title | Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms |
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