Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes
To study the effects of third trimester maternal isolated hypothyroxinemia (serum low free thyroxine and normal thyroid stimulating hormone level) on pregnancy outcomes, we performed a retrospective cohort study in women with singleton pregnancy between February 2009 and June 2012. Pregnant women we...
Gespeichert in:
| Veröffentlicht in: | ENDOCRINE JOURNAL 2023, Vol.70(6), pp.611-618 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 618 |
|---|---|
| container_issue | 6 |
| container_start_page | 611 |
| container_title | ENDOCRINE JOURNAL |
| container_volume | 70 |
| creator | Chen, Liangmiao Ye, Enling Sun, Mengli Lin, Hai Yu, Lechu Lin, Zhenzhen Peng, Mengmeng Lin, Dini Lu, Xuemian |
| description | To study the effects of third trimester maternal isolated hypothyroxinemia (serum low free thyroxine and normal thyroid stimulating hormone level) on pregnancy outcomes, we performed a retrospective cohort study in women with singleton pregnancy between February 2009 and June 2012. Pregnant women were assigned to two groups, a hypothyroxinemia group (with maternal isolated hypothyroxinemia in the third trimester and normal thyroid function in the first and second trimesters) and a control group (with normal serum thyroid functions). The pregnancy outcomes, including preterm birth, fetal distress, birth weight, premature rupture of membranes, and Apgar score at one minute after the birth, were recorded and compared between the two groups. A total of 3,945 pregnant women (median age 26 year old) were included in the study, with 195 women in the hypothyroxinemia group and 3,750 women in the control group. Compared with the women in the control group, women in the hypothyroxinemia group had higher incidences of premature rupture of membranes and low Apgar score at one minute after the birth. The multivariate logistic regression analysis showed that the low third trimester serum thyroxine level was the independent risk factor for the premature rupture of membranes and low Apgar score. There were no statistically significant differences in preterm birth, macrosomia, and intrauterine fetal distress between two groups. Third trimester maternal isolated hypothyroxinemia was associated with adverse pregnancy outcomes. The maternal serum thyroxine level should be monitored during late pregnancy and necessary management should be applied to improve the pregnancy outcomes. |
| doi_str_mv | 10.1507/endocrj.EJ22-0528 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2799172415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2799172415</sourcerecordid><originalsourceid>FETCH-LOGICAL-c647t-ea9fe2eda37604b82d1800907587b9dee0352c62068a8ebe531dc30c585f5ec23</originalsourceid><addsrcrecordid>eNpdkU9v1DAQxSMEokvhA3BBlrhwSRn_i51jVZUCqsQFzpbjzHa9SuKt7QD77XHYJSAuM5b885vneVX1msIVlaDe49QHF_dXt58Zq0Ey_aTaUC50LaSAp9UGWqpr3cr2onqR0h6Acyn48-qCK-AMGrmp8Dql4LzNPkykw_wDcSJ552NPcvQjpoyRjLbUyQ7EpzCUc092x0PIu2MMP_2Eo7fETj2x_XeMCckh4sNkJ3ckYc4uFJGX1bOtHRK-OvfL6tuH2683H-v7L3efbq7va9cIlWu07RYZ9parBkSnWU81QAtKatW1PSJwyVxTnGursUPJae84OKnlVqJj_LJ6d9I9xPA4F_Nm9MnhMNgJw5wMU21LFRNUFvTtf-g-zMsnC6UliEZRaAtFT5SLIaWIW3MoW7HxaCiYJQNzzsAsGZglg_LmzVl57kbs1xd_ll6AuxNQbr2zQ5iGssW_891j81vVMGDcACiApjRtoKF0KVowzsS_SvuU7QOuo2zM3g24mlNgmqWsJlfC7WwsGP8F98i14Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2850467109</pqid></control><display><type>article</type><title>Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes</title><source>J-STAGE Free</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Chen, Liangmiao ; Ye, Enling ; Sun, Mengli ; Lin, Hai ; Yu, Lechu ; Lin, Zhenzhen ; Peng, Mengmeng ; Lin, Dini ; Lu, Xuemian</creator><creatorcontrib>Chen, Liangmiao ; Ye, Enling ; Sun, Mengli ; Lin, Hai ; Yu, Lechu ; Lin, Zhenzhen ; Peng, Mengmeng ; Lin, Dini ; Lu, Xuemian ; Shandong Provincial Hospital ; Third Affiliated Hospital of Wenzhou Medical University ; Department of Endocrinology ; Shandong University</creatorcontrib><description>To study the effects of third trimester maternal isolated hypothyroxinemia (serum low free thyroxine and normal thyroid stimulating hormone level) on pregnancy outcomes, we performed a retrospective cohort study in women with singleton pregnancy between February 2009 and June 2012. Pregnant women were assigned to two groups, a hypothyroxinemia group (with maternal isolated hypothyroxinemia in the third trimester and normal thyroid function in the first and second trimesters) and a control group (with normal serum thyroid functions). The pregnancy outcomes, including preterm birth, fetal distress, birth weight, premature rupture of membranes, and Apgar score at one minute after the birth, were recorded and compared between the two groups. A total of 3,945 pregnant women (median age 26 year old) were included in the study, with 195 women in the hypothyroxinemia group and 3,750 women in the control group. Compared with the women in the control group, women in the hypothyroxinemia group had higher incidences of premature rupture of membranes and low Apgar score at one minute after the birth. The multivariate logistic regression analysis showed that the low third trimester serum thyroxine level was the independent risk factor for the premature rupture of membranes and low Apgar score. There were no statistically significant differences in preterm birth, macrosomia, and intrauterine fetal distress between two groups. Third trimester maternal isolated hypothyroxinemia was associated with adverse pregnancy outcomes. The maternal serum thyroxine level should be monitored during late pregnancy and necessary management should be applied to improve the pregnancy outcomes.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.EJ22-0528</identifier><identifier>PMID: 37032065</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Adult ; Apgar score ; Birth weight ; Female ; Fetal Distress ; Fetuses ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications - epidemiology ; Pregnancy Outcome ; Pregnancy Trimester, Third ; Premature Birth ; Premature rupture of membranes ; Retrospective Studies ; Risk factors ; Rupture ; Statistical analysis ; Third trimester ; Thyroid ; Thyroid function ; Thyroid gland ; Thyroxine</subject><ispartof>Endocrine Journal, 2023, Vol.70(6), pp.611-618</ispartof><rights>The Japan Endocrine Society</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c647t-ea9fe2eda37604b82d1800907587b9dee0352c62068a8ebe531dc30c585f5ec23</citedby><cites>FETCH-LOGICAL-c647t-ea9fe2eda37604b82d1800907587b9dee0352c62068a8ebe531dc30c585f5ec23</cites><orcidid>0000-0003-0882-4816 ; 0000-0002-0560-4028 ; 0000-0002-6687-5825 ; 0000-0003-4528-6981 ; 0000-0001-8282-3323 ; 0000-0002-2927-1731 ; 0000-0002-9702-6770 ; 0000-0002-5568-1531 ; 0000-0002-6716-3344</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,1881,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37032065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Liangmiao</creatorcontrib><creatorcontrib>Ye, Enling</creatorcontrib><creatorcontrib>Sun, Mengli</creatorcontrib><creatorcontrib>Lin, Hai</creatorcontrib><creatorcontrib>Yu, Lechu</creatorcontrib><creatorcontrib>Lin, Zhenzhen</creatorcontrib><creatorcontrib>Peng, Mengmeng</creatorcontrib><creatorcontrib>Lin, Dini</creatorcontrib><creatorcontrib>Lu, Xuemian</creatorcontrib><creatorcontrib>Shandong Provincial Hospital</creatorcontrib><creatorcontrib>Third Affiliated Hospital of Wenzhou Medical University</creatorcontrib><creatorcontrib>Department of Endocrinology</creatorcontrib><creatorcontrib>Shandong University</creatorcontrib><title>Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description>To study the effects of third trimester maternal isolated hypothyroxinemia (serum low free thyroxine and normal thyroid stimulating hormone level) on pregnancy outcomes, we performed a retrospective cohort study in women with singleton pregnancy between February 2009 and June 2012. Pregnant women were assigned to two groups, a hypothyroxinemia group (with maternal isolated hypothyroxinemia in the third trimester and normal thyroid function in the first and second trimesters) and a control group (with normal serum thyroid functions). The pregnancy outcomes, including preterm birth, fetal distress, birth weight, premature rupture of membranes, and Apgar score at one minute after the birth, were recorded and compared between the two groups. A total of 3,945 pregnant women (median age 26 year old) were included in the study, with 195 women in the hypothyroxinemia group and 3,750 women in the control group. Compared with the women in the control group, women in the hypothyroxinemia group had higher incidences of premature rupture of membranes and low Apgar score at one minute after the birth. The multivariate logistic regression analysis showed that the low third trimester serum thyroxine level was the independent risk factor for the premature rupture of membranes and low Apgar score. There were no statistically significant differences in preterm birth, macrosomia, and intrauterine fetal distress between two groups. Third trimester maternal isolated hypothyroxinemia was associated with adverse pregnancy outcomes. The maternal serum thyroxine level should be monitored during late pregnancy and necessary management should be applied to improve the pregnancy outcomes.</description><subject>Adult</subject><subject>Apgar score</subject><subject>Birth weight</subject><subject>Female</subject><subject>Fetal Distress</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimester, Third</subject><subject>Premature Birth</subject><subject>Premature rupture of membranes</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Rupture</subject><subject>Statistical analysis</subject><subject>Third trimester</subject><subject>Thyroid</subject><subject>Thyroid function</subject><subject>Thyroid gland</subject><subject>Thyroxine</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9v1DAQxSMEokvhA3BBlrhwSRn_i51jVZUCqsQFzpbjzHa9SuKt7QD77XHYJSAuM5b885vneVX1msIVlaDe49QHF_dXt58Zq0Ey_aTaUC50LaSAp9UGWqpr3cr2onqR0h6Acyn48-qCK-AMGrmp8Dql4LzNPkykw_wDcSJ552NPcvQjpoyRjLbUyQ7EpzCUc092x0PIu2MMP_2Eo7fETj2x_XeMCckh4sNkJ3ckYc4uFJGX1bOtHRK-OvfL6tuH2683H-v7L3efbq7va9cIlWu07RYZ9parBkSnWU81QAtKatW1PSJwyVxTnGursUPJae84OKnlVqJj_LJ6d9I9xPA4F_Nm9MnhMNgJw5wMU21LFRNUFvTtf-g-zMsnC6UliEZRaAtFT5SLIaWIW3MoW7HxaCiYJQNzzsAsGZglg_LmzVl57kbs1xd_ll6AuxNQbr2zQ5iGssW_891j81vVMGDcACiApjRtoKF0KVowzsS_SvuU7QOuo2zM3g24mlNgmqWsJlfC7WwsGP8F98i14Q</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Chen, Liangmiao</creator><creator>Ye, Enling</creator><creator>Sun, Mengli</creator><creator>Lin, Hai</creator><creator>Yu, Lechu</creator><creator>Lin, Zhenzhen</creator><creator>Peng, Mengmeng</creator><creator>Lin, Dini</creator><creator>Lu, Xuemian</creator><general>The Japan Endocrine Society</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0882-4816</orcidid><orcidid>https://orcid.org/0000-0002-0560-4028</orcidid><orcidid>https://orcid.org/0000-0002-6687-5825</orcidid><orcidid>https://orcid.org/0000-0003-4528-6981</orcidid><orcidid>https://orcid.org/0000-0001-8282-3323</orcidid><orcidid>https://orcid.org/0000-0002-2927-1731</orcidid><orcidid>https://orcid.org/0000-0002-9702-6770</orcidid><orcidid>https://orcid.org/0000-0002-5568-1531</orcidid><orcidid>https://orcid.org/0000-0002-6716-3344</orcidid></search><sort><creationdate>20230101</creationdate><title>Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes</title><author>Chen, Liangmiao ; Ye, Enling ; Sun, Mengli ; Lin, Hai ; Yu, Lechu ; Lin, Zhenzhen ; Peng, Mengmeng ; Lin, Dini ; Lu, Xuemian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c647t-ea9fe2eda37604b82d1800907587b9dee0352c62068a8ebe531dc30c585f5ec23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Apgar score</topic><topic>Birth weight</topic><topic>Female</topic><topic>Fetal Distress</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Trimester, Third</topic><topic>Premature Birth</topic><topic>Premature rupture of membranes</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Rupture</topic><topic>Statistical analysis</topic><topic>Third trimester</topic><topic>Thyroid</topic><topic>Thyroid function</topic><topic>Thyroid gland</topic><topic>Thyroxine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Liangmiao</creatorcontrib><creatorcontrib>Ye, Enling</creatorcontrib><creatorcontrib>Sun, Mengli</creatorcontrib><creatorcontrib>Lin, Hai</creatorcontrib><creatorcontrib>Yu, Lechu</creatorcontrib><creatorcontrib>Lin, Zhenzhen</creatorcontrib><creatorcontrib>Peng, Mengmeng</creatorcontrib><creatorcontrib>Lin, Dini</creatorcontrib><creatorcontrib>Lu, Xuemian</creatorcontrib><creatorcontrib>Shandong Provincial Hospital</creatorcontrib><creatorcontrib>Third Affiliated Hospital of Wenzhou Medical University</creatorcontrib><creatorcontrib>Department of Endocrinology</creatorcontrib><creatorcontrib>Shandong University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Liangmiao</au><au>Ye, Enling</au><au>Sun, Mengli</au><au>Lin, Hai</au><au>Yu, Lechu</au><au>Lin, Zhenzhen</au><au>Peng, Mengmeng</au><au>Lin, Dini</au><au>Lu, Xuemian</au><aucorp>Shandong Provincial Hospital</aucorp><aucorp>Third Affiliated Hospital of Wenzhou Medical University</aucorp><aucorp>Department of Endocrinology</aucorp><aucorp>Shandong University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>70</volume><issue>6</issue><spage>611</spage><epage>618</epage><pages>611-618</pages><artnum>EJ22-0528</artnum><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>To study the effects of third trimester maternal isolated hypothyroxinemia (serum low free thyroxine and normal thyroid stimulating hormone level) on pregnancy outcomes, we performed a retrospective cohort study in women with singleton pregnancy between February 2009 and June 2012. Pregnant women were assigned to two groups, a hypothyroxinemia group (with maternal isolated hypothyroxinemia in the third trimester and normal thyroid function in the first and second trimesters) and a control group (with normal serum thyroid functions). The pregnancy outcomes, including preterm birth, fetal distress, birth weight, premature rupture of membranes, and Apgar score at one minute after the birth, were recorded and compared between the two groups. A total of 3,945 pregnant women (median age 26 year old) were included in the study, with 195 women in the hypothyroxinemia group and 3,750 women in the control group. Compared with the women in the control group, women in the hypothyroxinemia group had higher incidences of premature rupture of membranes and low Apgar score at one minute after the birth. The multivariate logistic regression analysis showed that the low third trimester serum thyroxine level was the independent risk factor for the premature rupture of membranes and low Apgar score. There were no statistically significant differences in preterm birth, macrosomia, and intrauterine fetal distress between two groups. Third trimester maternal isolated hypothyroxinemia was associated with adverse pregnancy outcomes. The maternal serum thyroxine level should be monitored during late pregnancy and necessary management should be applied to improve the pregnancy outcomes.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>37032065</pmid><doi>10.1507/endocrj.EJ22-0528</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0882-4816</orcidid><orcidid>https://orcid.org/0000-0002-0560-4028</orcidid><orcidid>https://orcid.org/0000-0002-6687-5825</orcidid><orcidid>https://orcid.org/0000-0003-4528-6981</orcidid><orcidid>https://orcid.org/0000-0001-8282-3323</orcidid><orcidid>https://orcid.org/0000-0002-2927-1731</orcidid><orcidid>https://orcid.org/0000-0002-9702-6770</orcidid><orcidid>https://orcid.org/0000-0002-5568-1531</orcidid><orcidid>https://orcid.org/0000-0002-6716-3344</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-8959 |
| ispartof | Endocrine Journal, 2023, Vol.70(6), pp.611-618 |
| issn | 0918-8959 1348-4540 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2799172415 |
| source | J-STAGE Free; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Apgar score Birth weight Female Fetal Distress Fetuses Humans Infant, Newborn Pregnancy Pregnancy Complications - epidemiology Pregnancy Outcome Pregnancy Trimester, Third Premature Birth Premature rupture of membranes Retrospective Studies Risk factors Rupture Statistical analysis Third trimester Thyroid Thyroid function Thyroid gland Thyroxine |
| title | Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T09%3A19%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20third%20trimester%20maternal%20isolated%20hypothyroxinemia%20and%20adverse%20pregnancy%20outcomes&rft.jtitle=ENDOCRINE%20JOURNAL&rft.au=Chen,%20Liangmiao&rft.aucorp=Shandong%20Provincial%20Hospital&rft.date=2023-01-01&rft.volume=70&rft.issue=6&rft.spage=611&rft.epage=618&rft.pages=611-618&rft.artnum=EJ22-0528&rft.issn=0918-8959&rft.eissn=1348-4540&rft_id=info:doi/10.1507/endocrj.EJ22-0528&rft_dat=%3Cproquest_cross%3E2799172415%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2850467109&rft_id=info:pmid/37032065&rfr_iscdi=true |