Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study
To analyze and find risk factors associated with developing transient diabetes insipidus (DI) using a multicenter case series after trans-sphenoidal surgery. Medical records of patients who underwent trans-sphenoidal surgery for pituitary adenoma resection between 2010 and 2021 at 3 different neuros...
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| Veröffentlicht in: | World neurosurgery 2023-07, Vol.175, p.e636-e643 |
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| creator | Yasuda, Marcos Ezequiel Renedo, Daniela Sosa, Soledad Danilowicz, Karina Recalde, Rodolfo Zaninovich, Roberto Abbati, Santiago Gonzalez Cervio, Andrés Giovannini, Sebastian Villalonga, Juan Ulloque-Caamaño, Liezel Reddy, Kesava Socolovsky, Mariano Campero, Alvaro |
| description | To analyze and find risk factors associated with developing transient diabetes insipidus (DI) using a multicenter case series after trans-sphenoidal surgery.
Medical records of patients who underwent trans-sphenoidal surgery for pituitary adenoma resection between 2010 and 2021 at 3 different neurosurgical centers by 4 experienced neurosurgeons were retrospectively analyzed. The patients were divided into 2 groups (DI group or control group). Logistic regression analysis was conducted to identify risk factors associated with postoperative DI. Univariate logistic regression was performed to identify variables of interest. Covariates with a P value |
| doi_str_mv | 10.1016/j.wneu.2023.03.150 |
| format | Article |
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Medical records of patients who underwent trans-sphenoidal surgery for pituitary adenoma resection between 2010 and 2021 at 3 different neurosurgical centers by 4 experienced neurosurgeons were retrospectively analyzed. The patients were divided into 2 groups (DI group or control group). Logistic regression analysis was conducted to identify risk factors associated with postoperative DI. Univariate logistic regression was performed to identify variables of interest. Covariates with a P value <0.05 were incorporated into multivariate logistic regression models to identify independently associated risk factors for DI. All statistical tests were conducted using RStudio.
A total of 344 patients were included; 68% were women, the mean age was 46.5 years, and nonfunctioning adenomas were the most frequent (171, 49.7%). The mean tumor size was 20.3 mm. Covariates associated with postoperative DI were age, female gender, and gross total resection. The multivariable model showed that age (odds ratio [OR] 0.97, CI 0.95–0.99, P = 0.017) and female gender (OR 2.92, CI 1.50–6.03, P = 0.002) remained significant predictors of DI development. Gross total resection was no longer a significant predictor of DI in the multivariable model (OR 1.86, CI 0.99–3.71, P = 0.063), suggesting that this variable may be confounded by other factors.
The independent risk factors for the development of transient DI were female and young patients.</description><identifier>ISSN: 1878-8750</identifier><identifier>ISSN: 1878-8769</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2023.03.150</identifier><identifier>PMID: 37030477</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenohypophysis ; Adenoma ; Adenoma - pathology ; Arginine vasopressin deficiency ; Diabetes insipidus ; Diabetes Insipidus - epidemiology ; Diabetes Insipidus - etiology ; Diabetes Mellitus ; ERAS ; Female ; Humans ; Male ; Middle Aged ; Neurohypophysis ; Neurosurgery ; Pituitary neoplasms ; Pituitary Neoplasms - pathology ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Retrospective Studies ; Risk Factors ; Treatment Outcome</subject><ispartof>World neurosurgery, 2023-07, Vol.175, p.e636-e643</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-6b7dd42a9ed54b43b52397fa0ae1dcd862a35ac243509256a34c7c129101d4a3</citedby><cites>FETCH-LOGICAL-c356t-6b7dd42a9ed54b43b52397fa0ae1dcd862a35ac243509256a34c7c129101d4a3</cites><orcidid>0000-0002-7982-7662 ; 0000-0002-8850-1752 ; 0000-0002-0817-2734 ; 0000-0002-0667-3463 ; 0000-0001-5184-5052 ; 0000-0002-3973-3813 ; 0000-0002-4049-2711 ; 0000-0003-4120-6649</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.wneu.2023.03.150$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37030477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasuda, Marcos Ezequiel</creatorcontrib><creatorcontrib>Renedo, Daniela</creatorcontrib><creatorcontrib>Sosa, Soledad</creatorcontrib><creatorcontrib>Danilowicz, Karina</creatorcontrib><creatorcontrib>Recalde, Rodolfo</creatorcontrib><creatorcontrib>Zaninovich, Roberto</creatorcontrib><creatorcontrib>Abbati, Santiago Gonzalez</creatorcontrib><creatorcontrib>Cervio, Andrés</creatorcontrib><creatorcontrib>Giovannini, Sebastian</creatorcontrib><creatorcontrib>Villalonga, Juan</creatorcontrib><creatorcontrib>Ulloque-Caamaño, Liezel</creatorcontrib><creatorcontrib>Reddy, Kesava</creatorcontrib><creatorcontrib>Socolovsky, Mariano</creatorcontrib><creatorcontrib>Campero, Alvaro</creatorcontrib><title>Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>To analyze and find risk factors associated with developing transient diabetes insipidus (DI) using a multicenter case series after trans-sphenoidal surgery.
Medical records of patients who underwent trans-sphenoidal surgery for pituitary adenoma resection between 2010 and 2021 at 3 different neurosurgical centers by 4 experienced neurosurgeons were retrospectively analyzed. The patients were divided into 2 groups (DI group or control group). Logistic regression analysis was conducted to identify risk factors associated with postoperative DI. Univariate logistic regression was performed to identify variables of interest. Covariates with a P value <0.05 were incorporated into multivariate logistic regression models to identify independently associated risk factors for DI. All statistical tests were conducted using RStudio.
A total of 344 patients were included; 68% were women, the mean age was 46.5 years, and nonfunctioning adenomas were the most frequent (171, 49.7%). The mean tumor size was 20.3 mm. Covariates associated with postoperative DI were age, female gender, and gross total resection. The multivariable model showed that age (odds ratio [OR] 0.97, CI 0.95–0.99, P = 0.017) and female gender (OR 2.92, CI 1.50–6.03, P = 0.002) remained significant predictors of DI development. Gross total resection was no longer a significant predictor of DI in the multivariable model (OR 1.86, CI 0.99–3.71, P = 0.063), suggesting that this variable may be confounded by other factors.
The independent risk factors for the development of transient DI were female and young patients.</description><subject>Adenohypophysis</subject><subject>Adenoma</subject><subject>Adenoma - pathology</subject><subject>Arginine vasopressin deficiency</subject><subject>Diabetes insipidus</subject><subject>Diabetes Insipidus - epidemiology</subject><subject>Diabetes Insipidus - etiology</subject><subject>Diabetes Mellitus</subject><subject>ERAS</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurohypophysis</subject><subject>Neurosurgery</subject><subject>Pituitary neoplasms</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><issn>1878-8750</issn><issn>1878-8769</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1O3DAUhS3UqiDgBbpAXnYzqf8SJ1U3I-gUJFARzN5y7Dutp06c2g6Id-Ch69EAS7yxdX3OJ91zEPpMSUUJbb5uq8cR5ooRxivCK1qTA3REW9kuWtl0H97eNTlEpyltSTmcilbyT-iQS8KJkPIIPd-59BevtMkhJnwHXmewOAe8jnpMDsaML5zuIUPCV2UwOTsnfAEP4MM07L5Xwfvw6Mbfe0ua_sAYnNUe37o8u6zjE17aMht04Scw2YXxG17im9lnZwoiOoPv82yfTtDHjfYJTl_uY7Re_VifXy6uf_28Ol9eLwyvm7xoemmtYLoDW4te8L5mvJMbTTRQa2zbMM1rbZjgNelY3WgujDSUdSU4KzQ_Rl_22CmGfzOkrAaXDHivRwhzUkx2raSCSVmkbC81MaQUYaOm6IaykqJE7XpQW7XrQe16UISr0kMxnb3w534A-2Z5Tb0Ivu8FUJZ8cBBVMiVqA9bFko-ywb3H_w8hz5v9</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Yasuda, Marcos Ezequiel</creator><creator>Renedo, Daniela</creator><creator>Sosa, Soledad</creator><creator>Danilowicz, Karina</creator><creator>Recalde, Rodolfo</creator><creator>Zaninovich, Roberto</creator><creator>Abbati, Santiago Gonzalez</creator><creator>Cervio, Andrés</creator><creator>Giovannini, Sebastian</creator><creator>Villalonga, Juan</creator><creator>Ulloque-Caamaño, Liezel</creator><creator>Reddy, Kesava</creator><creator>Socolovsky, Mariano</creator><creator>Campero, Alvaro</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7982-7662</orcidid><orcidid>https://orcid.org/0000-0002-8850-1752</orcidid><orcidid>https://orcid.org/0000-0002-0817-2734</orcidid><orcidid>https://orcid.org/0000-0002-0667-3463</orcidid><orcidid>https://orcid.org/0000-0001-5184-5052</orcidid><orcidid>https://orcid.org/0000-0002-3973-3813</orcidid><orcidid>https://orcid.org/0000-0002-4049-2711</orcidid><orcidid>https://orcid.org/0000-0003-4120-6649</orcidid></search><sort><creationdate>202307</creationdate><title>Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study</title><author>Yasuda, Marcos Ezequiel ; Renedo, Daniela ; Sosa, Soledad ; Danilowicz, Karina ; Recalde, Rodolfo ; Zaninovich, Roberto ; Abbati, Santiago Gonzalez ; Cervio, Andrés ; Giovannini, Sebastian ; Villalonga, Juan ; Ulloque-Caamaño, Liezel ; Reddy, Kesava ; Socolovsky, Mariano ; Campero, Alvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-6b7dd42a9ed54b43b52397fa0ae1dcd862a35ac243509256a34c7c129101d4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenohypophysis</topic><topic>Adenoma</topic><topic>Adenoma - pathology</topic><topic>Arginine vasopressin deficiency</topic><topic>Diabetes insipidus</topic><topic>Diabetes Insipidus - epidemiology</topic><topic>Diabetes Insipidus - etiology</topic><topic>Diabetes Mellitus</topic><topic>ERAS</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurohypophysis</topic><topic>Neurosurgery</topic><topic>Pituitary neoplasms</topic><topic>Pituitary Neoplasms - pathology</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasuda, Marcos Ezequiel</creatorcontrib><creatorcontrib>Renedo, Daniela</creatorcontrib><creatorcontrib>Sosa, Soledad</creatorcontrib><creatorcontrib>Danilowicz, Karina</creatorcontrib><creatorcontrib>Recalde, Rodolfo</creatorcontrib><creatorcontrib>Zaninovich, Roberto</creatorcontrib><creatorcontrib>Abbati, Santiago Gonzalez</creatorcontrib><creatorcontrib>Cervio, Andrés</creatorcontrib><creatorcontrib>Giovannini, Sebastian</creatorcontrib><creatorcontrib>Villalonga, Juan</creatorcontrib><creatorcontrib>Ulloque-Caamaño, Liezel</creatorcontrib><creatorcontrib>Reddy, Kesava</creatorcontrib><creatorcontrib>Socolovsky, Mariano</creatorcontrib><creatorcontrib>Campero, Alvaro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasuda, Marcos Ezequiel</au><au>Renedo, Daniela</au><au>Sosa, Soledad</au><au>Danilowicz, Karina</au><au>Recalde, Rodolfo</au><au>Zaninovich, Roberto</au><au>Abbati, Santiago Gonzalez</au><au>Cervio, Andrés</au><au>Giovannini, Sebastian</au><au>Villalonga, Juan</au><au>Ulloque-Caamaño, Liezel</au><au>Reddy, Kesava</au><au>Socolovsky, Mariano</au><au>Campero, Alvaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2023-07</date><risdate>2023</risdate><volume>175</volume><spage>e636</spage><epage>e643</epage><pages>e636-e643</pages><issn>1878-8750</issn><issn>1878-8769</issn><eissn>1878-8769</eissn><abstract>To analyze and find risk factors associated with developing transient diabetes insipidus (DI) using a multicenter case series after trans-sphenoidal surgery.
Medical records of patients who underwent trans-sphenoidal surgery for pituitary adenoma resection between 2010 and 2021 at 3 different neurosurgical centers by 4 experienced neurosurgeons were retrospectively analyzed. The patients were divided into 2 groups (DI group or control group). Logistic regression analysis was conducted to identify risk factors associated with postoperative DI. Univariate logistic regression was performed to identify variables of interest. Covariates with a P value <0.05 were incorporated into multivariate logistic regression models to identify independently associated risk factors for DI. All statistical tests were conducted using RStudio.
A total of 344 patients were included; 68% were women, the mean age was 46.5 years, and nonfunctioning adenomas were the most frequent (171, 49.7%). The mean tumor size was 20.3 mm. Covariates associated with postoperative DI were age, female gender, and gross total resection. The multivariable model showed that age (odds ratio [OR] 0.97, CI 0.95–0.99, P = 0.017) and female gender (OR 2.92, CI 1.50–6.03, P = 0.002) remained significant predictors of DI development. Gross total resection was no longer a significant predictor of DI in the multivariable model (OR 1.86, CI 0.99–3.71, P = 0.063), suggesting that this variable may be confounded by other factors.
The independent risk factors for the development of transient DI were female and young patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37030477</pmid><doi>10.1016/j.wneu.2023.03.150</doi><orcidid>https://orcid.org/0000-0002-7982-7662</orcidid><orcidid>https://orcid.org/0000-0002-8850-1752</orcidid><orcidid>https://orcid.org/0000-0002-0817-2734</orcidid><orcidid>https://orcid.org/0000-0002-0667-3463</orcidid><orcidid>https://orcid.org/0000-0001-5184-5052</orcidid><orcidid>https://orcid.org/0000-0002-3973-3813</orcidid><orcidid>https://orcid.org/0000-0002-4049-2711</orcidid><orcidid>https://orcid.org/0000-0003-4120-6649</orcidid></addata></record> |
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| subjects | Adenohypophysis Adenoma Adenoma - pathology Arginine vasopressin deficiency Diabetes insipidus Diabetes Insipidus - epidemiology Diabetes Insipidus - etiology Diabetes Mellitus ERAS Female Humans Male Middle Aged Neurohypophysis Neurosurgery Pituitary neoplasms Pituitary Neoplasms - pathology Postoperative Complications - epidemiology Postoperative Complications - etiology Retrospective Studies Risk Factors Treatment Outcome |
| title | Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study |
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