Epithelium‐derived cystatin SN inhibits house dust mite protease activity in allergic asthma

Background Allergen source‐derived proteases are a critical factor in the formation and development of asthma. The cysteine protease activity of house dust mite (HDM) disrupts the epithelial barrier function. The expression of cystatin SN (CST1) is elevated in asthma epithelium. CST1 inhibits the cy...

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Veröffentlicht in:	Allergy (Copenhagen) 2023-06, Vol.78 (6), p.1507-1523
Hauptverfasser:	Yao, Lei, Yuan, Xijing, Fu, Heng, Guo, Qinxing, Wu, Yunhui, Xuan, Shurui, Kermani, Nazanin Zounemat, Adcock, Ian M., Zeng, Xiaoning, Liu, Yi, Xie, Min, Yao, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Animals Antigens, Dermatophagoides Asthma Asthma - etiology CST1 CST1 protein Cystatins Cysteine Cysteine Proteases Cysteine proteinase Dermatophagoides pteronyssinus Dust epithelial barrier function Epithelium HDM Humans Immunoglobulin E Mice Peptide Hydrolases Proteins Pyroglyphidae Respiratory function Salivary Cystatins Sputum
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