Targeted delivery of pexidartinib to tumor-associated macrophages via legumain-sensitive dual-coating nanoparticles for cancer immunotherapy

Tumor-associated macrophage (TAM) is regarded as an appealing cell target for cancer immunotherapy. However, it remains challenging to selectively eliminate M2-like TAM in tumor microenvironment. In this work, we employed a legumain-sensitive dual-coating nanosystem (s-Tpep-NPs) to deliver CSF-1R in...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2023-06, Vol.226, p.113283-113283, Article 113283
Hauptverfasser:	Liang, De-Sheng, You, Wei-Peng, Zhu, Fang-Fang, Wang, Jia-Hui, Guo, Feng, Xu, Jian-Jun, Liu, Xin-Liang, Zhong, Hai-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer immunotherapy drugs Dual-coating nanoparticles immunotherapy macrophages melanoma nanomedicine nanoparticles Pexidartinib Targeted delivery Tumor-associated macrophage
Online-Zugang:	Volltext
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