Ferroptosis: Promising approach for cancer and cancer immunotherapy
Ferroptosis is the cell death induced by ferrous ions and lipid peroxidation accumulation in tumor cells. Targeting ferroptosis, which is regulated by various metabolic and immune elements, might become a novel strategy for anti-tumor therapy. In this review, we will focus on the mechanism of ferrop...
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| Veröffentlicht in: | Cancer letters 2023-05, Vol.561, p.216152-216152, Article 216152 |
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| container_title | Cancer letters |
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| creator | Zheng, Shuyue Guan, Xin-Yuan |
| description | Ferroptosis is the cell death induced by ferrous ions and lipid peroxidation accumulation in tumor cells. Targeting ferroptosis, which is regulated by various metabolic and immune elements, might become a novel strategy for anti-tumor therapy. In this review, we will focus on the mechanism of ferroptosis and its interaction with cancer and tumor immune microenvironment, especially for the relationship between immune cells and ferroptosis. Also, we will discuss the latest preclinical progress of the collaboration between the ferroptosis-targeted drugs and immunotherapy, and the best potential conditions for their combined use. It will present a future insight on the possible value of ferroptosis in cancer immunotherapy.
•We discuss the latest therapeutic progress of the collaboration between the ferroptosis-targeted drugs and immunotherapy.•We use the concepts of "cold tumor" and "hot tumor" innovatively to discuss the relationship between immunotherapy and ferroptosis. |
| doi_str_mv | 10.1016/j.canlet.2023.216152 |
| format | Article |
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•We discuss the latest therapeutic progress of the collaboration between the ferroptosis-targeted drugs and immunotherapy.•We use the concepts of "cold tumor" and "hot tumor" innovatively to discuss the relationship between immunotherapy and ferroptosis.</description><subject>Cell Death</subject><subject>Drug Delivery Systems</subject><subject>Ferroptosis</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Neoplasms - therapy</subject><subject>Tumor Microenvironment</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9Lw0AQxRdRtFa_gUiOXlL3X5qNB0GKVaGgBz0vm9mJ3dJk424q-O3dEvXoaQbmvXkzP0IuGJ0xyubXmxmYbovDjFMuZpzNWcEPyISpkudlpeghmVBBZS6UKE7IaYwbSmkhy-KYnIgyeSqhJmSxxBB8P_jo4k32EnzrouveM9P3wRtYZ40PWQoCDJnp7G_r2nbX-WGNwfRfZ-SoMduI5z91St6W96-Lx3z1_PC0uFvlIOZ8yBFQQAlQgVFQ17Lg1kolOaQBzmXdAAjV8Eoq2timtmXBLFO8kVAIarAWU3I17k2nfewwDjodC7jdmg79Lmqe3i5pJSlNUjlKIfgYAza6D6414Uszqvf49EaP-PQenx7xJdvlT8KubtH-mX55JcHtKMD056fDoCM4TEisCwiDtt79n_ANowiEVQ</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Zheng, Shuyue</creator><creator>Guan, Xin-Yuan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4805-0483</orcidid><orcidid>https://orcid.org/0000-0003-1874-9805</orcidid></search><sort><creationdate>20230501</creationdate><title>Ferroptosis: Promising approach for cancer and cancer immunotherapy</title><author>Zheng, Shuyue ; Guan, Xin-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-ece3c7cc9ca8cbb452dd4842cecee64bfcc38f29480fdfbd751d182f4c530aeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cell Death</topic><topic>Drug Delivery Systems</topic><topic>Ferroptosis</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Neoplasms - therapy</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Shuyue</creatorcontrib><creatorcontrib>Guan, Xin-Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Shuyue</au><au>Guan, Xin-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ferroptosis: Promising approach for cancer and cancer immunotherapy</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>561</volume><spage>216152</spage><epage>216152</epage><pages>216152-216152</pages><artnum>216152</artnum><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Ferroptosis is the cell death induced by ferrous ions and lipid peroxidation accumulation in tumor cells. Targeting ferroptosis, which is regulated by various metabolic and immune elements, might become a novel strategy for anti-tumor therapy. In this review, we will focus on the mechanism of ferroptosis and its interaction with cancer and tumor immune microenvironment, especially for the relationship between immune cells and ferroptosis. Also, we will discuss the latest preclinical progress of the collaboration between the ferroptosis-targeted drugs and immunotherapy, and the best potential conditions for their combined use. It will present a future insight on the possible value of ferroptosis in cancer immunotherapy.
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| ispartof | Cancer letters, 2023-05, Vol.561, p.216152-216152, Article 216152 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cell Death Drug Delivery Systems Ferroptosis Humans Immunotherapy Neoplasms - therapy Tumor Microenvironment |
| title | Ferroptosis: Promising approach for cancer and cancer immunotherapy |
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