Capsaicin inhibits aortic valvular interstitial cell calcification via the redox-sensitive NFκB/AKT/ERK1/2 pathway

[Display omitted] Calcific aortic valve stenosis (CAVS), the third most prevalent cardiovascular disorder is known to impose a huge social and economic burden on patients. However, no pharmacotherapy has yet been established. Aortic valve replacement is the only treatment option, although its lifelo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 2023-06, Vol.212, p.115530-115530, Article 115530
Hauptverfasser:	Adhikari, Radhika, Jung, Jaehun, Shiwakoti, Saugat, Park, Eun-Young, Kim, Hyun-Jung, Ko, Ju-Young, You, Jaeyoon, Lee, Minho, Oak, Min-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Aortic Valve - metabolism Aortic Valve Stenosis - drug therapy Aortic Valve Stenosis - etiology Aortic Valve Stenosis - metabolism Calcific aortic valve stenosis Capsaicin Capsaicin - pharmacology Cells, Cultured Humans MAP Kinase Signaling System NF-kappa B - metabolism NFκB/AKT/ERK1/2 signaling pathway Oxidation-Reduction Oxidative stress Proto-Oncogene Proteins c-akt - metabolism Valvular interstitial cell
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!