Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease

Removal of the intron from precursor-tRNA (pre-tRNA) is essential in all three kingdoms of life. In humans, this process is mediated by the tRNA splicing endonuclease (TSEN) comprising four subunits: TSEN2, TSEN15, TSEN34, and TSEN54. Here, we report the cryo-EM structures of human TSEN bound to ful...

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Veröffentlicht in:	Molecular cell 2023-04, Vol.83 (8), p.1328-1339.e4
Hauptverfasser:	Zhang, Xiaofeng, Yang, Fenghua, Zhan, Xiechao, Bian, Tong, Xing, Zhihan, Lu, Yichen, Shi, Yigong
Format:	Artikel
Sprache:	eng
Schlagworte:	Endonucleases - genetics Endoribonucleases - genetics Humans Introns - genetics Nucleic Acid Conformation RNA metabolism RNA Precursors - genetics RNA Precursors - metabolism RNA Splice Sites RNA Splicing RNA, Transfer - genetics RNA, Transfer - metabolism splicing mechanism tRNA splicing tRNA splicing endonuclease
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