The Inhibition of Glycolysis in T Cells by a Jak Inhibitor Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice

Allergic contact dermatitis (ACD) and atopic dermatitis develop through delayed-type hypersensitivity reactions mediated by T cells. The development of immunomodulatory drugs, such as Jak inhibitors, would be useful for the long-term management of these diseases owing to their profile of favorable a...

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Veröffentlicht in:	Journal of investigative dermatology 2023-10, Vol.143 (10), p.1973-1982.e5
Hauptverfasser:	Okamoto, Michiko, Omori-Miyake, Miyuki, Kuwahara, Makoto, Okabe, Masataka, Eguchi, Mariko, Yamashita, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	ACD allergic contact dermatitis ECAR extracellular acidification rate Jak inhibitor Jakinib knockout lymph node Rux ruxolitinib T helper transgenic
Online-Zugang:	Volltext
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