Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site

Splicing is required for the removal of introns from a subset of transfer RNAs in all eukaryotic organisms. The first step of splicing, intron recognition and cleavage, is performed by the tRNA-splicing endonuclease, a tetrameric enzyme composed of the protein subunits Sen54, Sen2, Sen34 and Sen15....

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Veröffentlicht in:	Nature 2006-05, Vol.441 (7091), p.375-377
Hauptverfasser:	Trotta, Christopher R, Paushkin, Sergey V, Patel, Meenal, Li, Hong, Peltz, Stuart W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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