Olanzapine-induced nonalcoholic fatty liver disease: The effects of differential food pattern and the involvement of PGRMC1 signaling

Detrimental dietary habits with high-fat food are common in the psychiatric population, leading to higher obesity rate. Olanzapine (OLZ), as one of the mainstream antipsychotic drugs, shows superior efficacy in treating schizophrenia but limited by adverse effects such as obesity, dyslipidemia and l...

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Veröffentlicht in:	Food and chemical toxicology 2023-06, Vol.176, p.113757-113757, Article 113757
Hauptverfasser:	Zhu, ZhenYu, Cao, Ting, Chen, Hui, Zhang, BiKui, Lin, ChenQuan, Cai, HuaLin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals body weight changes diet Diet, High-Fat - adverse effects fatty liver Female females high fat foods High fatty supplementation hyperlipidemia Lipid accumulation Lipid Metabolism lipids liver Liver - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL NAFLD Non-alcoholic Fatty Liver Disease - metabolism obesity Obesity - metabolism Olanzapine Olanzapine - metabolism Olanzapine - therapeutic use Oxidative stress PGRMC1 progesterone receptors Receptors, Progesterone - genetics Receptors, Progesterone - metabolism risk schizophrenia therapeutics
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