Use of Naloxone in Angiotensin-Converting Enzyme Inhibitor Overdose: A Case Report
Angiotensin-converting enzyme (ACE) inhibitor overdose is an uncommonly presenting toxicologic emergency. Management is primarily supportive care, but a small body of evidence exists to support naloxone for management of hypotension. We present a case of accidental ACE inhibitor overdose. The patien...
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| Veröffentlicht in: | The Journal of emergency medicine 2023-03, Vol.64 (3), p.397-399 |
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| container_end_page | 399 |
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| container_issue | 3 |
| container_start_page | 397 |
| container_title | The Journal of emergency medicine |
| container_volume | 64 |
| creator | Haluska, Alexandra D. Davis, Austin Tarabishy, Noor Pena, Margarita E. |
| description | Angiotensin-converting enzyme (ACE) inhibitor overdose is an uncommonly presenting toxicologic emergency. Management is primarily supportive care, but a small body of evidence exists to support naloxone for management of hypotension.
We present a case of accidental ACE inhibitor overdose. The patient took approximately 300 mg lisinopril over 48 h and presented for evaluation of syncope. He was hypotensive and unresponsive to fluids. We administered naloxone with immediate and sustained resolution in hypotension. The mechanism of action is briefly discussed.
Naloxone is a rapid, low-risk, low-cost, and effective intervention for hypotension due to ACE inhibitor toxicity. It is supported by basic science research and clinical experience. |
| doi_str_mv | 10.1016/j.jemermed.2022.12.010 |
| format | Article |
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We present a case of accidental ACE inhibitor overdose. The patient took approximately 300 mg lisinopril over 48 h and presented for evaluation of syncope. He was hypotensive and unresponsive to fluids. We administered naloxone with immediate and sustained resolution in hypotension. The mechanism of action is briefly discussed.
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We present a case of accidental ACE inhibitor overdose. The patient took approximately 300 mg lisinopril over 48 h and presented for evaluation of syncope. He was hypotensive and unresponsive to fluids. We administered naloxone with immediate and sustained resolution in hypotension. The mechanism of action is briefly discussed.
Naloxone is a rapid, low-risk, low-cost, and effective intervention for hypotension due to ACE inhibitor toxicity. It is supported by basic science research and clinical experience.</description><subject>ACE inhibitor overdose</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Drug Overdose</subject><subject>Humans</subject><subject>hypotension</subject><subject>Hypotension - drug therapy</subject><subject>Lisinopril - pharmacology</subject><subject>Lisinopril - therapeutic use</subject><subject>lisinopril overdose</subject><subject>Male</subject><subject>naloxone</subject><subject>Naloxone - therapeutic use</subject><subject>Narcan</subject><subject>toxicology</subject><issn>0736-4679</issn><issn>2352-5029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQhi0EomV5hcpHLgleEtvhRFWxSQgkBGfLcSbFVWMXO62ApydV2zOnOfyb5kNoQklOCRXXi3wBHcQOmpwRxnLKckLJERozXrKsJKw6RmMiucgKIasROktpQQiVRNFTNOKiYmXBqzF6-0iAQ4tfzDJ8Bw_YeTz1cxd68Mn5bBb8BmLv_Bzf-d-fDvCT_3S160PEr4PShAQ3eIpnZuh5g1WI_QU6ac0yweX-nqOP-7v32WP2_PrwNJs-Z5YL1WcWKsFVoUrJjKC8aGpmoKytaJuaWtm21hRc1ay1rBK1bOkgSFIyUI2qVWH4Obra9a5i-FpD6nXnkoXl0ngI66SZrCQtlCDVYBU7q40hpQitXkXXmfijKdFbnnqhDzz1lqemTA88h-Bkv7Gut9ohdgA4GG53Bhg-3TiIOlkH3kLjItheN8H9t_EH93mKdQ</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Haluska, Alexandra D.</creator><creator>Davis, Austin</creator><creator>Tarabishy, Noor</creator><creator>Pena, Margarita E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202303</creationdate><title>Use of Naloxone in Angiotensin-Converting Enzyme Inhibitor Overdose: A Case Report</title><author>Haluska, Alexandra D. ; Davis, Austin ; Tarabishy, Noor ; Pena, Margarita E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-ce963848572a6134db2ae5bc6fdb1c7ffca438b2fc296b7f16fd7052e8d8b84a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ACE inhibitor overdose</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Drug Overdose</topic><topic>Humans</topic><topic>hypotension</topic><topic>Hypotension - drug therapy</topic><topic>Lisinopril - pharmacology</topic><topic>Lisinopril - therapeutic use</topic><topic>lisinopril overdose</topic><topic>Male</topic><topic>naloxone</topic><topic>Naloxone - therapeutic use</topic><topic>Narcan</topic><topic>toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haluska, Alexandra D.</creatorcontrib><creatorcontrib>Davis, Austin</creatorcontrib><creatorcontrib>Tarabishy, Noor</creatorcontrib><creatorcontrib>Pena, Margarita E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haluska, Alexandra D.</au><au>Davis, Austin</au><au>Tarabishy, Noor</au><au>Pena, Margarita E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Naloxone in Angiotensin-Converting Enzyme Inhibitor Overdose: A Case Report</atitle><jtitle>The Journal of emergency medicine</jtitle><addtitle>J Emerg Med</addtitle><date>2023-03</date><risdate>2023</risdate><volume>64</volume><issue>3</issue><spage>397</spage><epage>399</epage><pages>397-399</pages><issn>0736-4679</issn><eissn>2352-5029</eissn><abstract>Angiotensin-converting enzyme (ACE) inhibitor overdose is an uncommonly presenting toxicologic emergency. Management is primarily supportive care, but a small body of evidence exists to support naloxone for management of hypotension.
We present a case of accidental ACE inhibitor overdose. The patient took approximately 300 mg lisinopril over 48 h and presented for evaluation of syncope. He was hypotensive and unresponsive to fluids. We administered naloxone with immediate and sustained resolution in hypotension. The mechanism of action is briefly discussed.
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| ispartof | The Journal of emergency medicine, 2023-03, Vol.64 (3), p.397-399 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ACE inhibitor overdose Angiotensin-Converting Enzyme Inhibitors - therapeutic use Drug Overdose Humans hypotension Hypotension - drug therapy Lisinopril - pharmacology Lisinopril - therapeutic use lisinopril overdose Male naloxone Naloxone - therapeutic use Narcan toxicology |
| title | Use of Naloxone in Angiotensin-Converting Enzyme Inhibitor Overdose: A Case Report |
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